HitPredict

Interactor 1: C1R (P00736)
Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain (Complement C1r subcomponent chain A); Complement C1r subcomponent light chain (Complement C1r subcomponent chain B)]
Gene: C1R

Interactor 2: C1S (P09871)
Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain (Complement C1s subcomponent chain A); Complement C1s subcomponent light chain (Complement C1s subcomponent chain B)]
Gene: C1S

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.962

The method score is based on:

Property Details
Experiments 10878362, 28514442, 10092586, 33961781, 2387866, 12788922, 17996945
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, molecular sieving, surface plasmon resonance, protease assay
Interaction Type physical association, direct interaction, association, protein cleavage

The annotation score is based on:

Property Details
Interacting Pfam domains CUB~CUB, CUB~FXa_inhibition, CUB~Sushi, CUB~Trypsin, FXa_inhibition~Trypsin, Sushi~Sushi, Sushi~Trypsin, Trypsin~Trypsin
Common GO terms GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006958 - complement activation, classical pathway
and 2 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 11Aug2025