Protein: LEU3
3-isopropylmalate dehydrogenase (3-IPM-DH) (IMDH) (EC 1.1.1.85) (Beta-IPM dehydrogenase)

Gene: LEU3, LEU2
Organism: Saccharomyces cerevisiae S288C
Interactions: 168
UniProt ID: P04173

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003862 - 3-isopropylmalate dehydrogenase activity
GO:0005829 - cytosol
GO:0006097 - glyoxylate cycle
GO:0008652 - amino acid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378274

PHO85
Cyclin-dependent protein kinase PHO85

2

6

High-throughput

0.550

High

378252

KAPC
cAMP-dependent protein kinase type 3

1

3

High-throughput

0.500

High

378254

KAPB
cAMP-dependent protein kinase type 2

1

2

High-throughput

0.500

High

378256

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

High-throughput

0.500

High

378263

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.500

High

378267

EI2BA
Translation initiation factor eIF2B subunit alpha

1

2

High-throughput

0.500

High

378271

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.500

High

378278

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.500

High

378285

MDHC
Malate dehydrogenase, cytoplasmic

1

5

High-throughput

0.500

High

378287

NPR1
Nitrogen permease reactivator protein

1

3

High-throughput

0.500

High

378290

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

4

High-throughput

0.500

High

378291

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

4

High-throughput

0.500

High

378296

RV161
Reduced viability upon starvation protein 161

1

3

High-throughput

0.500

High

378304

HRR25
Casein kinase I homolog HRR25

1

1

High-throughput

0.500

High

378315

MKK2
MAP kinase kinase MKK2/SSP33

1

4

High-throughput

0.500

High

378316

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.500

High

378330

CAF4
CCR4-associated factor 4

1

8

High-throughput

0.500

High

378331

GBLP
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.500

High

378336

IMB2
Importin subunit beta-2

1

4

High-throughput

0.500

High

378348

PEX7
Peroxisomal targeting signal 2 receptor

1

10

High-throughput

0.500

High

378357

MET18
DNA repair/transcription protein MET18/MMS19

1

2

High-throughput

0.500

High

378358

SA185
SIT4-associating protein SAP185

1

1

High-throughput

0.500

High

378363

ATG18
Autophagy-related protein 18

1

4

High-throughput

0.500

High

378364

SA155
SIT4-associating protein SAP155

1

1

High-throughput

0.500

High

378371

RPN14
26S proteasome regulatory subunit RPN14

1

11

High-throughput

0.500

High

378374

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.500

High

378375

SSK2
MAP kinase kinase kinase SSK2

1

1

High-throughput

0.500

High

378381

TEP1
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1

1

1

High-throughput

0.500

High

378384

2ABA
Protein phosphatase PP2A regulatory subunit B

1

1

High-throughput

0.500

High

378385

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

6

High-throughput

0.500

High

378386

AP1M1
AP-1 complex subunit mu-1-I

1

3

High-throughput

0.500

High

378390

TRM82
tRNA

1

7

High-throughput

0.500

High

378402

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

6

High-throughput

0.500

High

378405

SHS1
Seventh homolog of septin 1

1

2

High-throughput

0.500

High

378416

AP2M
AP-2 complex subunit mu

1

3

High-throughput

0.500

High

378251

GAL1
Galactokinase

1

0

High-throughput

0.479

High

378261

CYAA
Adenylate cyclase

1

0

High-throughput

0.479

High

378264

SRS2
ATP-dependent DNA helicase SRS2

1

0

High-throughput

0.479

High

378286

PSB4
Proteasome subunit beta type-4

1

0

High-throughput

0.479

High

378312

CDC3
Cell division control protein 3

1

0

High-throughput

0.479

High

378320

DSS4
Protein DSS4

1

0

High-throughput

0.479

High

378329

SHE2
SWI5-dependent HO expression protein 2

1

0

High-throughput

0.479

High

378338

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.479

High

378355

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.479

High

378377

PAP2
Poly(A) RNA polymerase protein 2

1

0

High-throughput

0.479

High

378387

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.479

High

378406

PSR1
Phosphatase PSR1

1

0

High-throughput

0.479

High

365512

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.479

High

378270

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.479

High

378395

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

378253

CDC7
Cell division control protein 7

1

12

High-throughput

0.457

High

378257

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.457

High

378258

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.457

High

378259

PBS2
MAP kinase kinase PBS2

1

5

High-throughput

0.457

High

378260

SPS1
Sporulation-specific protein 1

1

1

High-throughput

0.457

High

378265

HAP3
Transcriptional activator HAP3

1

1

High-throughput

0.457

High

378266

KSS1
Mitogen-activated protein kinase KSS1

1

5

High-throughput

0.457

High

378268

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

2

High-throughput

0.457

High

378269

AMPL
Vacuolar aminopeptidase 1

1

1

High-throughput

0.457

High

378272

TUP1
General transcriptional corepressor TUP1

1

5

High-throughput

0.457

High

378276

GBB
Guanine nucleotide-binding protein subunit beta

1

4

High-throughput

0.457

High

378277

CDC42
Cell division control protein 42

1

3

High-throughput

0.457

High

378279

PRP6
Pre-mRNA-splicing factor 6

1

2

High-throughput

0.457

High

378280

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

4

High-throughput

0.457

High

378282

PP11
Serine/threonine-protein phosphatase PP1-1

1

3

High-throughput

0.457

High

378289

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.457

High

378293

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

4

High-throughput

0.457

High

378295

CDC10
Cell division control protein 10

1

1

High-throughput

0.457

High

378297

DMC1
Meiotic recombination protein DMC1

1

2

High-throughput

0.457

High

378298

GID7
Glucose-induced degradation protein 7

1

6

High-throughput

0.457

High

378300

PWP2
Periodic tryptophan protein 2

1

5

High-throughput

0.457

High

378303

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

1

High-throughput

0.457

High

378305

NTH1
Endonuclease III homolog 1

1

1

High-throughput

0.457

High

378307

DBF20
Serine/threonine-protein kinase DBF20

1

5

High-throughput

0.457

High

378309

KNS1
Dual specificity protein kinase KNS1

1

1

High-throughput

0.457

High

378310

ARP2
Actin-related protein 2

1

1

High-throughput

0.457

High

378314

HIR1
Protein HIR1

1

3

High-throughput

0.457

High

378317

DUR1
Urea amidolyase [Includes: Urea carboxylase

1

1

High-throughput

0.457

High

378318

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

High-throughput

0.457

High

378321

RAD24
Checkpoint protein RAD24

1

1

High-throughput

0.457

High

378322

KU70
ATP-dependent DNA helicase II subunit 1

1

3

High-throughput

0.457

High

378323

PRS6B
26S proteasome regulatory subunit 6B homolog

1

3

High-throughput

0.457

High

378326

DCA13
Protein SOF1

1

4

High-throughput

0.457

High

378327

SIP2
SNF1 protein kinase subunit beta-2

1

2

High-throughput

0.457

High

378332

TAF5
Transcription initiation factor TFIID subunit 5

1

2

High-throughput

0.457

High

378333

CHK1
Serine/threonine-protein kinase CHK1

1

1

High-throughput

0.457

High

378334

AP3M
AP-3 complex subunit mu

1

3

High-throughput

0.457

High

378337

SIF2
SIR4-interacting protein SIF2

1

5

High-throughput

0.457

High

378339

RCK1
Serine/threonine-protein kinase RCK1

1

3

High-throughput

0.457

High

378340

RCK2
Serine/threonine-protein kinase RCK2

1

4

High-throughput

0.457

High

378341

DBP8
ATP-dependent RNA helicase DBP8

1

1

High-throughput

0.457

High

378345

TEM1
Protein TEM1

1

1

High-throughput

0.457

High

378346

DUN1
DNA damage response protein kinase DUN1

1

3

High-throughput

0.457

High

378347

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.457

High

378350

RBG1
Ribosome-interacting GTPase 1

1

1

High-throughput

0.457

High

378352

HAT2
Histone acetyltransferase type B subunit 2

1

6

High-throughput

0.457

High

378360

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

1

High-throughput

0.457

High

378361

SMK1
Sporulation-specific mitogen-activated protein kinase SMK1

1

5

High-throughput

0.457

High

378362

COPB2
Coatomer subunit beta'

1

8

High-throughput

0.457

High

378372

CDH1
APC/C activator protein CDH1

1

5

High-throughput

0.457

High

378373

FMP48
Probable serine/threonine-protein kinase FMP48

1

3

High-throughput

0.457

High

378376

COPA
Coatomer subunit alpha

1

8

High-throughput

0.457

High

378379

RHO5
GTP-binding protein RHO5

1

4

High-throughput

0.457

High

378380

CBK1
Serine/threonine-protein kinase CBK1

1

5

High-throughput

0.457

High

378391

VHS1
Serine/threonine-protein kinase VHS1

1

2

High-throughput

0.457

High

378392

WDR59
Maintenance of telomere capping protein 5

1

11

High-throughput

0.457

High

378394

UTP5
U3 small nucleolar RNA-associated protein 5

1

6

High-throughput

0.457

High

378397

KU80
ATP-dependent DNA helicase II subunit 2

1

3

High-throughput

0.457

High

378399

ERB1
Ribosome biogenesis protein ERB1

1

4

High-throughput

0.457

High

378403

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

4

High-throughput

0.457

High

378404

SSK1
Osmolarity two-component system protein SSK1

1

1

High-throughput

0.457

High

378407

RBX1
RING-box protein HRT1

1

1

High-throughput

0.457

High

378408

YTM1
Ribosome biogenesis protein YTM1

1

4

High-throughput

0.457

High

378409

YP150
Putative serine/threonine-protein kinase YPL150W

1

1

High-throughput

0.457

High

378412

HRT3
F-box protein HRT3

1

1

High-throughput

0.457

High

378414

PRP46
Pre-mRNA-splicing factor PRP46

1

8

High-throughput

0.457

High

378415

SKS1
Serine/threonine-protein kinase SKS1

1

3

High-throughput

0.457

High

357141

RMAR
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.437

High

378302

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.437

High

378308

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.437

High

378365

SMC3
Structural maintenance of chromosomes protein 3

1

1

Small-scale

0.437

High

378368

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.437

High

378411

SMC4
Structural maintenance of chromosomes protein 4

1

1

Small-scale

0.437

High

378356

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.426

High

378255

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.261

Low

378262

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

0

High-throughput

0.261

Low

378273

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.261

Low

378275

HPR1
THO complex subunit HPR1

1

0

High-throughput

0.261

Low

378281

FKBP
FK506-binding protein 1

1

0

High-throughput

0.261

Low

378283

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.261

Low

378284

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.261

Low

378288

SAN1
Protein SAN1

1

0

High-throughput

0.261

Low

378292

VAN1
Mannan polymerase I complex VAN1 subunit

1

0

High-throughput

0.261

Low

378294

MSH3
DNA mismatch repair protein MSH3

1

0

High-throughput

0.261

Low

378299

DPO4
DNA polymerase IV

1

0

High-throughput

0.261

Low

378301

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

0

High-throughput

0.261

Low

378306

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

High-throughput

0.261

Low

378311

SFP1
Transcription factor SFP1

1

0

High-throughput

0.261

Low

378313

HYM1
Protein HYM1

1

0

High-throughput

0.261

Low

378319

FIMB
Fimbrin

1

0

High-throughput

0.261

Low

378324

XRS2
DNA repair protein XRS2

1

0

High-throughput

0.261

Low

378325

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.261

Low

378328

PP2C3
Protein phosphatase 2C homolog 3

1

0

High-throughput

0.261

Low

378335

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

0

High-throughput

0.261

Low

378342

TRM5
tRNA

1

0

High-throughput

0.261

Low

378343

RAD55
DNA repair protein RAD55

1

0

High-throughput

0.261

Low

378349

VPS8
Vacuolar protein sorting-associated protein 8

1

0

High-throughput

0.261

Low

378351

SLN1
Osmosensing histidine protein kinase SLN1

1

0

High-throughput

0.261

Low

378353

PTP3
Tyrosine-protein phosphatase 3

1

0

High-throughput

0.261

Low

378354

SECU
Securin

1

0

High-throughput

0.261

Low

378359

PAC11
WD repeat-containing protein PAC11

1

0

High-throughput

0.261

Low

378366

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.261

Low

378367

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.261

Low

378369

INP52
Polyphosphatidylinositol phosphatase INP52

1

0

High-throughput

0.261

Low

378370

NUP84
Nucleoporin NUP84

1

0

High-throughput

0.261

Low

378378

ELOA1
Elongin-A

1

0

High-throughput

0.261

Low

378382

APP1
Phosphatidate phosphatase APP1

1

0

High-throughput

0.261

Low

378383

YE066
Putative uncharacterized protein YER066C-A

1

0

High-throughput

0.261

Low

378388

UME1
Transcriptional regulatory protein UME1

1

0

High-throughput

0.261

Low

378393

VPS64
Vacuolar protein sorting-associated protein 64

1

0

High-throughput

0.261

Low

378396

LCD1
DNA damage checkpoint protein LCD1

1

0

High-throughput

0.261

Low

378398

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.261

Low

378400

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.261

Low

378410

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.261

Low

378413

SWM1
Anaphase-promoting complex subunit SWM1

1

0

High-throughput

0.261

Low

378344

VPS41
Vacuolar protein sorting-associated protein 41

1

0

High-throughput

0.249

Low

378389

ESP1
Separin

1

0

High-throughput

0.249

Low

378401

HRQ1
ATP-dependent helicase HRQ1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024