Protein: RPOA
DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC 2.7.7.6) (RNA polymerase subunit alpha) (Transcriptase subunit alpha)

Gene: RPOA
Organism: Escherichia coli K-12
Interactions: 100
UniProt ID: P0A7Z4

Gene Ontology (top 5):
GO:0000345 - cytosolic DNA-directed RNA polymerase complex
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

494592

RPOC
DNA-directed RNA polymerase subunit beta'

5

4

Small-scale

0.926

High

494625

RPOH
RNA polymerase sigma factor RpoH

3

4

High-throughput

0.848

High

365811

RPOD
RNA polymerase sigma factor RpoD

2

4

High-throughput

0.789

High

494593

RPOB
DNA-directed RNA polymerase subunit beta

2

4

High-throughput

0.789

High

494632

RP54
RNA polymerase sigma-54 factor

2

1

High-throughput

0.789

High

494616

NUSA
Transcription termination/antitermination protein NusA

2

0

Small-scale

0.765

High

494617

NUSG
Transcription termination/antitermination protein NusG

2

0

High-throughput

0.749

High

494644

RAPA
RNA polymerase-associated protein RapA

2

0

High-throughput

0.749

High

493197

RS10
Small ribosomal subunit protein uS10

2

0

High-throughput

0.736

High

494647

RL24
Large ribosomal subunit protein uL24

2

0

High-throughput

0.736

High

494620

RHO
Transcription termination factor Rho

2

0

High-throughput

0.720

High

494615

FLIA
RNA polymerase sigma factor FliA

1

4

High-throughput

0.691

High

494595

FUR
Ferric uptake regulation protein

1

0

High-throughput

0.656

High

494645

RL2
Large ribosomal subunit protein uL2

3

0

Small-scale

0.635

High

494628

RPOS
RNA polymerase sigma factor RpoS

1

4

High-throughput

0.625

High

494609

ROB
Right origin-binding protein

1

0

High-throughput

0.613

High

490802

GREA
Transcription elongation factor GreA

2

1

High-throughput

0.612

High

494227

RS5
Small ribosomal subunit protein uS5

2

1

High-throughput

0.612

High

494600

CSPC
Cold shock-like protein CspC

2

1

High-throughput

0.601

High

494588

RPOZ
DNA-directed RNA polymerase subunit omega

1

0

High-throughput

0.593

High

494627

RCSB
Transcriptional regulatory protein RcsB

1

0

High-throughput

0.593

High

494587

RPOA
DNA-directed RNA polymerase subunit alpha

1

1

Small-scale

0.590

High

493561

RS19
Small ribosomal subunit protein uS19

2

1

High-throughput

0.588

High

494608

DBHB
DNA-binding protein HU-beta

2

1

High-throughput

0.588

High

494613

RS15
Small ribosomal subunit protein uS15

2

1

High-throughput

0.588

High

494624

RS1
Small ribosomal subunit protein bS1

2

1

High-throughput

0.588

High

494636

LHR
Lhr helicase/uracil glycosylase

1

0

High-throughput

0.586

High

383998

RL15
Large ribosomal subunit protein uL15

2

0

High-throughput

0.585

High

494029

RS4
Small ribosomal subunit protein uS4

2

0

High-throughput

0.585

High

382552

RS6
Small ribosomal subunit protein bS6

2

0

High-throughput

0.576

High

492570

RL19
Large ribosomal subunit protein bL19

2

0

High-throughput

0.576

High

492889

RL28
Large ribosomal subunit protein bL28

2

0

High-throughput

0.576

High

493079

RL33
Large ribosomal subunit protein bL33

2

0

High-throughput

0.576

High

493595

RS20
Small ribosomal subunit protein bS20

2

0

High-throughput

0.576

High

494621

RL21
Large ribosomal subunit protein bL21

2

0

High-throughput

0.576

High

494623

RS14
Small ribosomal subunit protein uS14

2

0

High-throughput

0.576

High

494650

RS21
Small ribosomal subunit protein bS21

2

0

High-throughput

0.576

High

492860

RL27
Large ribosomal subunit protein bL27

2

0

High-throughput

0.563

High

494589

TPIS
Triosephosphate isomerase

2

0

High-throughput

0.563

High

494596

G3P1
Glyceraldehyde-3-phosphate dehydrogenase A

2

0

High-throughput

0.563

High

494598

MREB
Cell shape-determining protein MreB

2

0

High-throughput

0.563

High

494603

YBCJ
Putative RNA-binding protein YbcJ

2

0

High-throughput

0.563

High

494611

RL16
Large ribosomal subunit protein uL16

2

0

High-throughput

0.563

High

494612

RL23
Large ribosomal subunit protein uL23

2

0

High-throughput

0.563

High

494629

SYD
Aspartate--tRNA ligase

2

0

High-throughput

0.563

High

494631

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

2

0

High-throughput

0.563

High

494651

NFI
Endonuclease V

2

0

High-throughput

0.563

High

494626

SSB
Single-stranded DNA-binding protein

2

0

High-throughput

0.547

High

494597

PTA
Phosphate acetyltransferase

1

0

High-throughput

0.513

High

494604

COABC
Coenzyme A biosynthesis bifunctional protein CoaBC

1

0

High-throughput

0.513

High

494605

EBGC
Evolved beta-galactosidase subunit beta

1

0

High-throughput

0.513

High

494622

RL6
Large ribosomal subunit protein uL6

1

0

High-throughput

0.513

High

494630

FECI
Ferric citrate uptake sigma factor FecI

1

0

High-throughput

0.513

High

494639

YEGD
Uncharacterized chaperone protein YegD

1

0

High-throughput

0.513

High

494641

ETK
Tyrosine-protein kinase etk

1

0

High-throughput

0.513

High

382647

RS7
Small ribosomal subunit protein uS7

1

1

High-throughput

0.484

High

421103

PNP
Polyribonucleotide nucleotidyltransferase

1

1

High-throughput

0.484

High

492682

RL1
Large ribosomal subunit protein uL1

1

1

High-throughput

0.484

High

493681

RS2
Small ribosomal subunit protein uS2

1

1

High-throughput

0.484

High

493844

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.484

High

494599

CSPA
Cold shock protein CspA

1

1

High-throughput

0.484

High

494607

DBHA
DNA-binding protein HU-alpha

1

1

High-throughput

0.484

High

494637

GREB
Transcription elongation factor GreB

1

1

High-throughput

0.484

High

494646

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.484

High

365863

DPO1
DNA polymerase I

1

0

High-throughput

0.464

High

437526

TSAD
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.464

High

444278

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.464

High

449823

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

1

0

High-throughput

0.464

High

450091

RF2
Peptide chain release factor RF2

1

0

High-throughput

0.464

High

469898

USG
USG-1 protein

1

0

High-throughput

0.464

High

490862

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

492459

RL7
Large ribosomal subunit protein bL12

1

0

High-throughput

0.464

High

493352

RS13
Small ribosomal subunit protein uS13

1

0

High-throughput

0.464

High

493461

RS16
Small ribosomal subunit protein bS16

1

0

High-throughput

0.464

High

494601

RL13
Large ribosomal subunit protein uL13

1

0

High-throughput

0.464

High

494606

SSPA
Stringent starvation protein A

1

0

High-throughput

0.464

High

494618

ODP1
Pyruvate dehydrogenase E1 component

1

0

High-throughput

0.464

High

494634

WAAU
Putative lipopolysaccharide heptosyltransferase 4

1

0

High-throughput

0.464

High

494643

OBG
GTPase ObgE/CgtA

1

0

High-throughput

0.464

High

494648

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.464

High

494649

RL5
Large ribosomal subunit protein uL5

1

0

High-throughput

0.464

High

491846

NAGB
Glucosamine-6-phosphate deaminase

1

0

High-throughput

0.458

High

494591

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.458

High

494594

RIMI
[Ribosomal protein bS18]-alanine N-acetyltransferase

1

0

High-throughput

0.458

High

494610

MAOP
Macrodomain Ori protein

1

0

High-throughput

0.458

High

494633

YIDC
Membrane protein insertase YidC

1

0

Small-scale

0.458

High

494638

POTF
Putrescine-binding periplasmic protein PotF

1

0

High-throughput

0.458

High

494652

CSRA
Carbon storage regulator

1

0

High-throughput

0.458

High

494653

KDGR
HTH-type transcriptional regulator KdgR

1

0

High-throughput

0.458

High

494654

MSRC
Free methionine-R-sulfoxide reductase

1

0

High-throughput

0.458

High

494655

YQHD
NADPH-dependent aldehyde reductase YqhD

1

0

High-throughput

0.458

High

494635

WECG
UDP-N-acetyl-D-mannosaminuronic acid transferase

2

0

High-throughput

0.313

High

494602

HYBE
Hydrogenase-2 operon protein HybE

1

0

High-throughput

0.279

Low

494619

YBBO
Uncharacterized oxidoreductase YbbO

1

0

High-throughput

0.261

Low

494590

YACL
UPF0231 protein YacL

1

0

High-throughput

0.253

Low

494614

CEDA
Cell division activator CedA

1

0

High-throughput

0.253

Low

494656

YGCP
Uncharacterized protein YgcP

1

0

High-throughput

0.253

Low

494640

WBBK
Putative glycosyltransferase WbbK

1

0

High-throughput

0.249

Low

494642

AG43
Antigen 43

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025