Protein: RPD3
Histone deacetylase RPD3 (EC 3.5.1.98) (Transcriptional regulatory protein RPD3)

Gene: RPD3
Organism: Saccharomyces cerevisiae S288C
Interactions: 134
UniProt ID: P32561

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0004407 - histone deacetylase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

692995

RPD3
Histone deacetylase RPD3

3

15

Small-scale

0.827

High

609058

SIN3
Transcriptional regulatory protein SIN3

23

20

Small-scale

0.766

High

693043

PHO23
Transcriptional regulatory protein PHO23

14

5

Small-scale

0.761

High

693063

RCO1
Transcriptional regulatory protein RCO1

12

20

Small-scale

0.759

High

693071

CTI6
Histone deacetylase complex subunit CTI6

13

7

Small-scale

0.758

High

693077

EAF3
Chromatin modification-related protein EAF3

9

6

Small-scale

0.752

High

693057

UME1
Transcriptional regulatory protein UME1

14

0

Small-scale

0.728

High

693009

RXT2
Transcriptional regulatory protein RXT2

14

0

Small-scale

0.728

High

693031

SDS3
Transcriptional regulatory protein SDS3

13

0

Small-scale

0.726

High

693011

SAP30
Transcriptional regulatory protein SAP30

12

0

Small-scale

0.726

High

680074

DEP1
Transcriptional regulatory protein DEP1

10

0

Small-scale

0.722

High

693066

RXT3
Transcriptional regulatory protein RXT3

8

0

Small-scale

0.717

High

693003

ASH1
Transcriptional regulatory protein ASH1

7

0

Small-scale

0.709

High

693015

UME6
Transcriptional regulatory protein UME6

6

0

Small-scale

0.697

High

693050

H3
Histone H3

4

18

Small-scale

0.680

High

388094

TOP1
DNA topoisomerase 1

2

2

High-throughput

0.621

High

549985

CSK21
Casein kinase II subunit alpha

2

16

High-throughput

0.621

High

693039

CYP7
Peptidyl-prolyl cis-trans isomerase CYP7

2

6

Small-scale

0.620

High

693048

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

2

6

Small-scale

0.620

High

542112

CYC8
General transcriptional corepressor CYC8

2

13

Small-scale

0.618

High

561855

TUP1
General transcriptional corepressor TUP1

2

20

Small-scale

0.612

High

664709

BMH1
Protein BMH1

2

8

Small-scale

0.594

High

693013

CSK2C
Casein kinase II subunit beta'

2

1

High-throughput

0.588

High

693068

CDC45
Cell division control protein 45

2

0

High-throughput

0.576

High

693055

ADA2
Transcriptional adapter 2

1

4

High-throughput

0.575

High

599433

VPS1
Vacuolar protein sorting-associated protein 1

2

0

High-throughput

0.563

High

693001

NCBP1
Nuclear cap-binding protein complex subunit 1

2

0

High-throughput

0.563

High

693047

NRD1
Protein NRD1

2

0

High-throughput

0.563

High

605953

RAD53
Serine/threonine-protein kinase RAD53

1

6

Small-scale

0.561

High

693044

INO80
Chromatin-remodeling ATPase INO80

1

20

Small-scale

0.561

High

693059

ECM5
Protein ECM5

1

15

Small-scale

0.554

High

693026

SSB2
Ribosome-associated molecular chaperone SSB2

2

19

High-throughput

0.552

High

693002

SIP2
SNF1 protein kinase subunit beta-2

1

0

Small-scale

0.545

High

405152

RL17A
Large ribosomal subunit protein uL22A

1

5

High-throughput

0.536

High

693041

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

9

High-throughput

0.536

High

693045

SNT2
E3 ubiquitin-protein ligase SNT2

1

8

Small-scale

0.536

High

693060

GCN5
Histone acetyltransferase GCN5

1

19

High-throughput

0.536

High

693008

NU170
Nucleoporin NUP170

2

1

Small-scale

0.533

High

540546

CYPH
Peptidyl-prolyl cis-trans isomerase

1

5

Small-scale

0.515

High

610956

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

Small-scale

0.515

High

693076

WHI5
G1-specific transcriptional repressor WHI5

1

1

Small-scale

0.515

High

693079

H2AZ
Histone H2A.Z

1

15

Small-scale

0.501

High

562202

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

6

Small-scale

0.500

High

693016

TCPB
T-complex protein 1 subunit beta

1

20

Small-scale

0.500

High

693035

TCPH
T-complex protein 1 subunit eta

1

20

Small-scale

0.500

High

693040

RS12
Small ribosomal subunit protein eS12

1

2

Small-scale

0.500

High

693038

MTC1
Maintenance of telomere capping protein 1

1

0

High-throughput

0.493

High

693058

HOT1
High-osmolarity-induced transcription protein 1

1

0

Small-scale

0.493

High

405969

RL33A
Large ribosomal subunit protein eL33A

1

2

High-throughput

0.489

High

691304

NGG1
Chromatin-remodeling complexes subunit NGG1

1

0

Small-scale

0.480

High

356336

H4
Histone H4

1

13

High-throughput

0.479

High

557949

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

Small-scale

0.479

High

606590

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

661662

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

680537

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

687669

BTAF1
TATA-binding protein-associated factor MOT1

1

20

Small-scale

0.479

High

688153

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

691003

HOG1
Mitogen-activated protein kinase HOG1

1

7

Small-scale

0.479

High

693004

BMH2
Protein BMH2

1

8

Small-scale

0.479

High

693007

GBLP
Small ribosomal subunit protein RACK1

1

14

Small-scale

0.479

High

693010

HSL7
Protein arginine N-methyltransferase HSL7

1

1

Small-scale

0.479

High

693049

ARP5
Actin-related protein 5

1

9

Small-scale

0.479

High

693061

NHP10
Non-histone protein 10

1

20

Small-scale

0.479

High

693065

TOS4
Protein TOS4

1

2

Small-scale

0.479

High

693072

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

693075

ARP8
Actin-like protein ARP8

1

13

Small-scale

0.479

High

693078

CMR1
DNA damage-binding protein CMR1

1

20

High-throughput

0.479

High

693080

SMC6
Structural maintenance of chromosomes protein 6

1

17

High-throughput

0.479

High

692997

IES6
Chromatin-remodeling complex subunit IES6

1

0

Small-scale

0.458

High

692999

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

693006

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

693014

ASPG1
L-asparaginase 1

1

0

High-throughput

0.458

High

693025

IES5
Ino eighty subunit 5

1

0

Small-scale

0.458

High

693027

IES2
Ino eighty subunit 2

1

0

Small-scale

0.458

High

693028

ATG3
Autophagy-related protein 3

1

0

Small-scale

0.458

High

693030

XBP1
Transcriptional repressor XBP1

1

0

Small-scale

0.458

High

693032

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

693033

HAC1
Transcriptional activator HAC1

1

0

Small-scale

0.458

High

693036

IES1
Ino eighty subunit 1

1

0

Small-scale

0.458

High

693042

TAF4
Transcription initiation factor TFIID subunit 4

1

0

High-throughput

0.458

High

693062

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

693064

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

693067

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

693069

SGO1
Shugoshin

1

0

High-throughput

0.458

High

693070

IES4
Ino eighty subunit 4

1

0

Small-scale

0.458

High

693074

IES3
Ino eighty subunit 3

1

0

Small-scale

0.458

High

357477

RLA4
Large ribosomal subunit protein P2B

1

3

Small-scale

0.457

High

399859

RLA2
Large ribosomal subunit protein P2A

1

3

Small-scale

0.457

High

427209

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

Small-scale

0.457

High

481753

RS16B
Small ribosomal subunit protein uS9B

1

3

Small-scale

0.457

High

519912

TCPA
T-complex protein 1 subunit alpha

1

20

Small-scale

0.457

High

693017

TCPG
T-complex protein 1 subunit gamma

1

20

Small-scale

0.457

High

693018

TCPD
T-complex protein 1 subunit delta

1

20

Small-scale

0.457

High

693019

TCPZ
T-complex protein 1 subunit zeta

1

20

Small-scale

0.457

High

693029

TCPE
T-complex protein 1 subunit epsilon

1

20

Small-scale

0.457

High

693051

ACAC
Acetyl-CoA carboxylase

1

15

Small-scale

0.457

High

350797

RAS2
Ras-like protein 2

1

8

Small-scale

0.445

High

355401

H2B1
Histone H2B.1

1

20

High-throughput

0.445

High

376692

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

6

High-throughput

0.445

High

399377

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.445

High

404528

RL7A
Large ribosomal subunit protein uL30A

1

4

High-throughput

0.445

High

406895

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.445

High

480407

RS6B
Small ribosomal subunit protein eS6B

1

3

Small-scale

0.445

High

490664

HSP71
Heat shock protein SSA1

1

18

High-throughput

0.445

High

493477

HSP72
Heat shock protein SSA2

1

18

High-throughput

0.445

High

510643

SSB1
Ribosome-associated molecular chaperone SSB1

1

19

High-throughput

0.445

High

627830

SIS1
Protein SIS1

1

8

High-throughput

0.445

High

628940

SCJ1
DnaJ-related protein SCJ1

1

7

High-throughput

0.445

High

633050

MAS5
Mitochondrial protein import protein MAS5

1

8

High-throughput

0.445

High

692996

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

693005

SPT7
Transcriptional activator SPT7

1

20

High-throughput

0.445

High

693020

CAJ1
Protein CAJ1

1

9

High-throughput

0.445

High

693024

PFD2
Prefoldin subunit 2

1

2

High-throughput

0.445

High

693034

RL10
Large ribosomal subunit protein uL16

1

5

High-throughput

0.445

High

693053

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

20

High-throughput

0.445

High

693073

RL7B
Large ribosomal subunit protein uL30B

1

4

High-throughput

0.445

High

404987

RL6B
Large ribosomal subunit protein eL6B

1

4

Small-scale

0.437

High

479994

RS6A
Small ribosomal subunit protein eS6A

1

3

Small-scale

0.437

High

482846

RL35A
Large ribosomal subunit protein uL29A

1

2

High-throughput

0.437

High

692998

CACP
Carnitine O-acetyltransferase, mitochondrial

1

1

High-throughput

0.437

High

693023

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

693012

SPT8
Transcription factor SPT8

1

0

High-throughput

0.426

High

693022

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

693052

UBC7
Ubiquitin-conjugating enzyme E2 7

1

6

High-throughput

0.417

High

535199

RS17B
Small ribosomal subunit protein eS17B

1

4

High-throughput

0.407

High

613659

RS3A2
Small ribosomal subunit protein eS1B

1

6

High-throughput

0.407

High

667138

RL8B
Large ribosomal subunit protein eL8B

1

3

High-throughput

0.407

High

693000

RS3A1
Small ribosomal subunit protein eS1A

1

6

High-throughput

0.407

High

693021

RS14B
Small ribosomal subunit protein uS11B

1

2

High-throughput

0.407

High

693037

RL17B
Large ribosomal subunit protein uL22B

1

5

High-throughput

0.407

High

693054

RL6A
Large ribosomal subunit protein eL6A

1

4

High-throughput

0.407

High

693046

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.269

Low

693056

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024