Protein: TIG
Trigger factor (TF) (EC 5.2.1.8) (PPIase)

Gene: TIG
Organism: Escherichia coli K-12
Interactions: 160
UniProt ID: P0A850

Gene Ontology (top 5):
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005829 - cytosol
GO:0009408 - response to heat
GO:0015031 - protein transport
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

382650

RS7
Small ribosomal subunit protein uS7

2

1

Small-scale

0.776

High

494904

TIG
Trigger factor

2

0

Small-scale

0.716

High

491339

HTPG
Chaperone protein HtpG

1

0

High-throughput

0.656

High

494915

SLYD
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

1

0

High-throughput

0.656

High

494941

RL23
Large ribosomal subunit protein uL23

2

0

High-throughput

0.635

High

494910

OMPA
Outer membrane protein A

3

0

Small-scale

0.632

High

494230

RS5
Small ribosomal subunit protein uS5

3

0

Small-scale

0.622

High

490634

FABA
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

3

0

Small-scale

0.607

High

492892

RL28
Large ribosomal subunit protein bL28

3

0

Small-scale

0.607

High

493847

RS3
Small ribosomal subunit protein uS3

2

0

Small-scale

0.576

High

494401

RS9
Small ribosomal subunit protein uS9

2

0

Small-scale

0.576

High

494931

SDHA
Succinate dehydrogenase flavoprotein subunit

2

0

Small-scale

0.576

High

494939

RL14
Large ribosomal subunit protein uL14

2

0

Small-scale

0.576

High

494951

RL6
Large ribosomal subunit protein uL6

2

0

Small-scale

0.576

High

494996

RS21
Small ribosomal subunit protein bS21

2

0

Small-scale

0.576

High

494991

RL3
Large ribosomal subunit protein uL3

2

1

Small-scale

0.570

High

492190

PUR7
Phosphoribosylaminoimidazole-succinocarboxamide synthase

2

0

High-throughput

0.563

High

494921

GLNB
Nitrogen regulatory protein P-II 1

2

0

High-throughput

0.563

High

494932

HNS
DNA-binding protein H-NS

2

0

High-throughput

0.563

High

493299

RS11
Small ribosomal subunit protein uS11

2

0

Small-scale

0.547

High

494953

RS1
Small ribosomal subunit protein bS1

2

0

Small-scale

0.545

High

494992

RL4
Large ribosomal subunit protein uL4

2

0

Small-scale

0.545

High

480572

PFLB
Formate acetyltransferase 1

1

1

High-throughput

0.536

High

495003

GRE2
Probable dehydratase YbiW

1

1

High-throughput

0.536

High

493026

RL29
Large ribosomal subunit protein uL29

1

0

High-throughput

0.523

High

432119

APAH
Bis(5'-nucleosyl)-tetraphosphatase [symmetrical]

1

0

High-throughput

0.517

High

393981

OMPF
Outer membrane porin F

1

0

High-throughput

0.513

High

450116

SDHB
Succinate dehydrogenase iron-sulfur subunit

1

0

High-throughput

0.513

High

483697

PUTA
Bifunctional protein PutA [Includes: Proline dehydrogenase

1

0

High-throughput

0.513

High

490247

CLPP
ATP-dependent Clp protease proteolytic subunit

1

0

High-throughput

0.513

High

494907

RPOC
DNA-directed RNA polymerase subunit beta'

1

0

High-throughput

0.513

High

494908

RPOB
DNA-directed RNA polymerase subunit beta

1

0

High-throughput

0.513

High

494914

G3P1
Glyceraldehyde-3-phosphate dehydrogenase A

1

0

High-throughput

0.513

High

494917

PTA
Phosphate acetyltransferase

1

0

High-throughput

0.513

High

494929

FLIT
Flagellar protein FliT

1

0

High-throughput

0.513

High

494945

ODP1
Pyruvate dehydrogenase E1 component

1

0

High-throughput

0.513

High

494960

NADE
NH(3)-dependent NAD(+) synthetase

1

0

High-throughput

0.513

High

494961

NARY
Respiratory nitrate reductase 2 beta chain

1

0

High-throughput

0.513

High

494962

NARZ
Respiratory nitrate reductase 2 alpha chain

1

0

High-throughput

0.513

High

494997

KAD
Adenylate kinase

1

0

High-throughput

0.513

High

494969

MAK
Fructokinase

1

1

High-throughput

0.500

High

494970

ACNA
Aconitate hydratase A

1

1

High-throughput

0.500

High

420185

RBSA
Ribose import ATP-binding protein RbsA

1

0

High-throughput

0.493

High

494957

RHSC
Protein RhsC

1

1

High-throughput

0.489

High

494958

RHSD
Protein RhsD

1

1

High-throughput

0.489

High

494964

KPYK2
Pyruvate kinase II

1

1

High-throughput

0.484

High

491421

IF2
Translation initiation factor IF-2

1

0

High-throughput

0.479

High

494937

EDD
Phosphogluconate dehydratase

1

0

High-throughput

0.479

High

489271

LEUC
3-isopropylmalate dehydratase large subunit

1

1

High-throughput

0.479

High

494936

KPYK1
Pyruvate kinase I

1

1

High-throughput

0.479

High

490126

CH10
Co-chaperonin GroES

1

0

High-throughput

0.464

High

490864

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

492063

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.464

High

494657

RPOZ
DNA-directed RNA polymerase subunit omega

1

0

High-throughput

0.464

High

494930

ASPA
Aspartate ammonia-lyase

1

0

High-throughput

0.464

High

494934

TDCA
HTH-type transcriptional regulator TdcA

1

0

High-throughput

0.464

High

494942

GLTJ
Glutamate/aspartate import permease protein GltJ

1

0

High-throughput

0.464

High

494984

PRMB
Ribosomal protein uL3 glutamine methyltransferase

1

0

High-throughput

0.464

High

362089

AAT
Aspartate aminotransferase

1

0

High-throughput

0.458

High

490462

UXAB
Altronate oxidoreductase

1

0

Small-scale

0.458

High

491849

NAGB
Glucosamine-6-phosphate deaminase

1

0

High-throughput

0.458

High

494906

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.458

High

494916

P5CR
Pyrroline-5-carboxylate reductase

1

0

High-throughput

0.458

High

494926

KBL
2-amino-3-ketobutyrate coenzyme A ligase

1

0

High-throughput

0.458

High

494927

CISY
Citrate synthase

1

0

High-throughput

0.458

High

494928

DPS
DNA protection during starvation protein

1

0

High-throughput

0.458

High

494935

LETA
Lipophilic envelope-spanning tunnel protein A

1

0

High-throughput

0.458

High

494947

GCH1L
GTP cyclohydrolase 1 type 2 homolog

1

0

High-throughput

0.458

High

494972

GLNE
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme

1

0

High-throughput

0.458

High

494973

PANB
3-methyl-2-oxobutanoate hydroxymethyltransferase

1

0

High-throughput

0.458

High

494974

POTF
Putrescine-binding periplasmic protein PotF

1

0

High-throughput

0.458

High

494981

GLF
UDP-galactopyranose mutase

1

0

High-throughput

0.458

High

495000

CSRA
Carbon storage regulator

1

0

High-throughput

0.458

High

494944

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex

1

1

Small-scale

0.445

High

494731

METK
S-adenosylmethionine synthase

1

0

High-throughput

0.438

High

369139

CARB
Carbamoyl phosphate synthase large chain

1

0

Small-scale

0.426

High

444280

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.426

High

478490

AVTA
Valine--pyruvate aminotransferase

1

0

Small-scale

0.426

High

489234

UVRA
UvrABC system protein A

1

0

Small-scale

0.426

High

489434

CARA
Carbamoyl phosphate synthase small chain

1

0

Small-scale

0.426

High

490787

GLK
Glucokinase

1

0

Small-scale

0.426

High

492369

RL10
Large ribosomal subunit protein uL10

1

0

Small-scale

0.426

High

492462

RL7
Large ribosomal subunit protein bL12

1

0

Small-scale

0.426

High

492685

RL1
Large ribosomal subunit protein uL1

1

0

Small-scale

0.426

High

493201

RS10
Small ribosomal subunit protein uS10

1

0

Small-scale

0.426

High

493563

RS19
Small ribosomal subunit protein uS19

1

0

Small-scale

0.426

High

494031

RS4
Small ribosomal subunit protein uS4

1

0

High-throughput

0.426

High

494533

RNC
Ribonuclease 3

1

0

Small-scale

0.426

High

494913

FTNA
Bacterial non-heme ferritin

1

0

Small-scale

0.426

High

494918

GATD
Galactitol 1-phosphate 5-dehydrogenase

1

0

Small-scale

0.426

High

494919

GLDA
Glycerol dehydrogenase

1

0

Small-scale

0.426

High

494922

RL13
Large ribosomal subunit protein uL13

1

0

Small-scale

0.426

High

494943

NUOE
NADH-quinone oxidoreductase subunit E

1

0

Small-scale

0.426

High

494946

PDXH
Pyridoxine/pyridoxamine 5'-phosphate oxidase

1

0

Small-scale

0.426

High

494949

RHO
Transcription termination factor Rho

1

0

Small-scale

0.426

High

494950

RL17
Large ribosomal subunit protein bL17

1

0

Small-scale

0.426

High

494954

PSTS
Phosphate-binding protein PstS

1

0

Small-scale

0.426

High

494955

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

0

Small-scale

0.426

High

494965

ASNB
Asparagine synthetase B [glutamine-hydrolyzing]

1

0

Small-scale

0.426

High

494966

TRMA
tRNA/tmRNA

1

0

Small-scale

0.426

High

494967

KITH
Thymidine kinase

1

0

Small-scale

0.426

High

494988

LUXS
S-ribosylhomocysteine lyase

1

0

Small-scale

0.426

High

494990

RL2
Large ribosomal subunit protein uL2

1

0

Small-scale

0.426

High

494993

RL22
Large ribosomal subunit protein uL22

1

0

Small-scale

0.426

High

494994

RL5
Large ribosomal subunit protein uL5

1

0

Small-scale

0.426

High

494998

MBHT
Hydrogenase-2 small chain

1

0

Small-scale

0.426

High

494999

PTKA
PTS system galactitol-specific EIIA component

1

0

Small-scale

0.426

High

495009

ISPD
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

1

0

Small-scale

0.426

High

457824

THGA
Galactoside O-acetyltransferase

1

1

Small-scale

0.407

High

494920

MREB
Cell shape-determining protein MreB

1

1

Small-scale

0.407

High

494933

CRA
Catabolite repressor/activator

1

1

Small-scale

0.407

High

494987

NANK
N-acetylmannosamine kinase

1

1

Small-scale

0.407

High

495008

MAA
Maltose O-acetyltransferase

1

1

Small-scale

0.407

High

494924

HYPC
Hydrogenase maturation factor HypC

2

0

High-throughput

0.307

High

494995

YDIH
Uncharacterized protein YdiH

2

0

High-throughput

0.307

High

493686

RS2
Small ribosomal subunit protein uS2

2

0

Small-scale

0.297

High

365944

BGAL
Beta-galactosidase

1

0

High-throughput

0.279

Low

494905

UXAC
Uronate isomerase

1

0

High-throughput

0.279

Low

494923

FTSH
ATP-dependent zinc metalloprotease FtsH

1

0

High-throughput

0.279

Low

494925

YCGL
Protein YcgL

1

0

High-throughput

0.279

Low

494948

FOLM
Dihydromonapterin reductase

1

0

High-throughput

0.279

Low

494963

FADB
Fatty acid oxidation complex subunit alpha [Includes: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase

1

0

High-throughput

0.279

Low

494968

PPSA
Phosphoenolpyruvate synthase

1

0

High-throughput

0.279

Low

494979

EAEH
Putative attaching and effacing protein homolog

1

0

High-throughput

0.279

Low

494983

RSPA
Starvation-sensing protein RspA

1

0

High-throughput

0.279

Low

367308

DCDA
Diaminopimelate decarboxylase

1

0

High-throughput

0.253

Low

494975

ADEC
Adenine deaminase

1

0

High-throughput

0.253

Low

495004

SAD
Succinate semialdehyde dehydrogenase [NAD(P)+] Sad

1

0

High-throughput

0.253

Low

495005

YNIB
Uncharacterized protein YniB

1

0

High-throughput

0.253

Low

495010

TAPT
tRNA-uridine aminocarboxypropyltransferase

1

0

High-throughput

0.253

Low

393862

PBPA
Penicillin-binding protein 1A

1

0

High-throughput

0.249

Low

494909

BLC
Outer membrane lipoprotein Blc

1

0

High-throughput

0.249

Low

494911

RIMI
[Ribosomal protein bS18]-alanine N-acetyltransferase

1

0

High-throughput

0.249

Low

494912

GLPC
Anaerobic glycerol-3-phosphate dehydrogenase subunit C

1

0

High-throughput

0.249

Low

494971

LHR
Lhr helicase/uracil glycosylase

1

0

High-throughput

0.249

Low

494980

YHJD
Inner membrane protein YhjD

1

0

High-throughput

0.249

Low

494982

WBBK
Putative glycosyltransferase WbbK

1

0

High-throughput

0.249

Low

494985

YJDJ
Uncharacterized protein YjdJ

1

0

High-throughput

0.249

Low

494989

CSIE
Stationary phase-inducible protein CsiE

1

0

High-throughput

0.249

Low

495001

PXPA
5-oxoprolinase subunit A

1

0

High-throughput

0.249

Low

495002

RLMF
Ribosomal RNA large subunit methyltransferase F

1

0

High-throughput

0.249

Low

495007

GLSA1
Glutaminase 1

1

0

High-throughput

0.249

Low

495011

YAFV
Omega-amidase YafV

1

0

High-throughput

0.249

Low

490717

FLGH
Flagellar L-ring protein

1

0

High-throughput

0.238

Low

494986

EPMB
L-lysine 2,3-aminomutase

1

0

High-throughput

0.238

Low

365721

AK1H
Bifunctional aspartokinase/homoserine dehydrogenase 1

1

0

Small-scale

0.232

Low

383999

RL15
Large ribosomal subunit protein uL15

1

0

Small-scale

0.232

Low

431417

FPG
Formamidopyrimidine-DNA glycosylase

1

0

Small-scale

0.232

Low

449974

HIS7
Histidine biosynthesis bifunctional protein HisB [Includes: Histidinol-phosphatase

1

0

Small-scale

0.232

Low

490389

DADA
D-amino acid dehydrogenase

1

0

Small-scale

0.232

Low

494938

FABY
Probable acyltransferase FabY

1

0

Small-scale

0.232

Low

494940

RL16
Large ribosomal subunit protein uL16

1

0

Small-scale

0.232

Low

494952

RS14
Small ribosomal subunit protein uS14

1

0

Small-scale

0.232

Low

494956

GATZ
D-tagatose-1,6-bisphosphate aldolase subunit GatZ

1

0

Small-scale

0.232

Low

494959

ARGD
Acetylornithine/succinyldiaminopimelate aminotransferase

1

0

Small-scale

0.232

Low

494976

NUDC
NAD-capped RNA hydrolase NudC

1

0

Small-scale

0.232

Low

494977

OPGG
Glucans biosynthesis protein G

1

0

Small-scale

0.232

Low

494978

CBPA
Curved DNA-binding protein

1

0

Small-scale

0.232

Low

495006

A2MGH
Putative alpha-2-macroglobulin homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025