HitPredict

Interactor 1: ZAP70 (P43404)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70

Interactor 2: SLAP2 (Q8R4L0)
Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2)
Gene: Sla2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12024036
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 618 Mm			1 259
+	Mm
		440274 ZAP70_MOUSE (1-618): 0: 640: 100.00		LCK_MOUSE (3-255): 1.19e-77: 245: 31.78
+	Hs
		440432 ZAP70_HUMAN (1-618): 0: 620: 93.39		FYN_HUMAN (18-256): 2.1e-80: 253: 31.84
+	Hs
		439986 ZAP70_HUMAN (1-618): 0: 620: 93.39		LCK_HUMAN (22-255): 1.28e-77: 245: 32.22
+	Mm
		849101 ZAP70_MOUSE (1-618): 0: 640: 100.00		SLAP1_MOUSE (13-255): 1.31e-65: 207: 42.63
+	Hs
		849081 ZAP70_HUMAN (1-618): 0: 620: 93.39		SLAP2_HUMAN (1-259): 1.94e-69: 216: 78.24
+	Hs
		362200 ZAP70_HUMAN (1-618): 0: 620: 93.39		ABL1_HUMAN (9-256): 9.21e-62: 211: 24.02
+	Hs
		849066 ZAP70_HUMAN (1-618): 0: 620: 93.39		SLAP1_HUMAN (13-255): 1.07e-60: 194: 41.87
+	Mm
		571267 KSYK_MOUSE (3-598): 0: 549: 53.86		FGR_MOUSE (4-256): 8.83e-84: 261: 31.68
+	Mm
		683089 KSYK_MOUSE (3-598): 0: 549: 53.86		LYN_MOUSE (4-256): 1.25e-83: 260: 32.05
+	Hs
		849061 ZAP70_HUMAN (1-618): 0: 620: 93.39		GRB2_HUMAN (36-241): 4.96e-59: 188: 22.90
+	Hs
		463392 KSYK_HUMAN (1-598): 0: 548: 54.05		LYN_HUMAN (4-256): 3.11e-83: 259: 31.66
+	Hs
		440433 KSYK_HUMAN (1-598): 0: 548: 54.05		FYN_HUMAN (18-256): 2.1e-80: 253: 31.84
+	Hs
		486668 KSYK_HUMAN (1-598): 0: 548: 54.05		FGR_HUMAN (33-256): 1.69e-79: 250: 32.17
+	Mm
		431332 KSYK_MOUSE (3-598): 0: 549: 53.86		SRC_MOUSE (2-256): 9.07e-79: 248: 27.97
+	Hs
		557163 KSYK_HUMAN (1-598): 0: 548: 54.05		SRC_HUMAN (21-256): 5.93e-78: 246: 30.17
+	Hs
		439987 KSYK_HUMAN (1-598): 0: 548: 54.05		LCK_HUMAN (22-255): 1.28e-77: 245: 32.22
+	Hs
		849135 KSYK_HUMAN (1-598): 0: 548: 54.05		GRB2_HUMAN (36-241): 4.96e-59: 188: 22.90
+	Hs
		834152 ZAP70_HUMAN (1-618): 0: 620: 93.39		CSK_HUMAN (37-193): 1.71e-13: 71.2: 33.73
+	Gg
		98977 KSYK_CHICK (1-601): 0: 573: 53.12		CSK_CHICK (37-193): 1.18e-13: 72: 33.73
+	Hs
		292816 KSYK_HUMAN (1-598): 0: 548: 54.05		GRAP2_HUMAN (36-175): 4.99e-15: 75.1: 35.71