Interactor 1: ZAP70 (P43404)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70
Interactor 2: CRK (Q64010)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK
Species: Mus musculus
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.44 | 1.00 | 0.665 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 21037577 |
| Identification Methods | anti tag coimmunoprecipitation, anti bait coimmunoprecipitation |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH2~SH3_2 |
| Common GO terms | GO:0001784 - phosphotyrosine residue binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
