Protein: DOT6
Transcriptional regulatory protein DOT6 (Disrupter of telomere silencing protein 6) (PAC-binding factor 2)

Gene: DOT6
Organism: Saccharomyces cerevisiae S288C
Interactions: 37
UniProt ID: P40059

Gene Ontology (top 5):
GO:0000183 - rDNA heterochromatin formation
GO:0000781 - chromosome, telomeric region
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

392801

HSP82
ATP-dependent molecular chaperone HSP82

3

0

High-throughput

0.613

High

817689

RXT3
Transcriptional regulatory protein RXT3

2

0

High-throughput

0.563

High

817691

CTI6
Histone deacetylase complex subunit CTI6

2

1

Small-scale

0.552

High

548900

SCH9
Serine/threonine-protein kinase SCH9

1

1

Small-scale

0.550

High

545034

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.536

High

721973

XPO1
Exportin-1

1

0

High-throughput

0.513

High

817683

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

441146

KAPA
cAMP-dependent protein kinase type 1

1

0

Small-scale

0.504

High

817680

NST1
Stress response protein NST1

1

0

High-throughput

0.493

High

707215

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

735503

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

High-throughput

0.479

High

817677

SDS3
Transcriptional regulatory protein SDS3

1

1

Small-scale

0.479

High

817679

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

817684

GIS1
Transcriptional activator/repressor GIS1

1

1

High-throughput

0.479

High

817686

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

817688

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

817690

SGO1
Shugoshin

1

1

High-throughput

0.479

High

817693

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

817694

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.479

High

438707

SC160
Protein SCP160

1

0

High-throughput

0.458

High

694556

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.458

High

763901

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

817678

MPH1
ATP-dependent DNA helicase MPH1

1

0

High-throughput

0.458

High

817681

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

817682

MOT3
Transcriptional activator/repressor MOT3

1

0

High-throughput

0.458

High

817685

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

817687

PAL1
Protein PAL1

1

0

High-throughput

0.458

High

817692

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

524081

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

526804

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

817674

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

817675

6P21
6-phosphofructo-2-kinase 1

1

1

High-throughput

0.445

High

649968

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.426

High

689048

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.249

Low

795005

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

807811

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

817676

MLP2
Protein MLP2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025