Protein: MPH1
ATP-dependent DNA helicase MPH1 (EC 3.6.4.12) (FANCM-like protein 1) (Mutator phenotype protein 1)

Gene: MPH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 103
UniProt ID: P40562

Gene Ontology (top 5):
GO:0000400 - four-way junction DNA binding
GO:0000725 - recombinational repair
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0007535 - donor selection

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

647782

RFA1
Replication factor A protein 1

8

10

Small-scale

0.747

High

826409

SMC5
Structural maintenance of chromosomes protein 5

6

18

Small-scale

0.742

High

824981

FKH1
Fork head protein homolog 1

4

9

Small-scale

0.701

High

826389

YG1T
Uncharacterized protein YGR042W

5

0

Small-scale

0.683

High

826397

MSH6
DNA mismatch repair protein MSH6

3

3

High-throughput

0.662

High

744751

MG101
Mitochondrial genome maintenance protein MGM101

4

0

Small-scale

0.649

High

632567

DBP3
ATP-dependent RNA helicase DBP3

1

17

Small-scale

0.621

High

643644

SNF2
Transcription regulatory protein SNF2

1

18

High-throughput

0.618

High

763281

SGS1
ATP-dependent helicase SGS1

1

18

High-throughput

0.618

High

826387

INO80
Chromatin-remodeling ATPase INO80

1

20

High-throughput

0.618

High

826419

CMR1
DNA damage-binding protein CMR1

1

13

High-throughput

0.618

High

524206

HSP71
Heat shock protein SSA1

2

8

High-throughput

0.611

High

448458

RAD52
DNA repair and recombination protein RAD52

2

0

Small-scale

0.559

High

817582

UTP7
U3 small nucleolar RNA-associated protein 7

1

13

Small-scale

0.555

High

826410

RTC1
Restriction of telomere capping protein 1

1

11

High-throughput

0.553

High

688751

RFA2
Replication factor A protein 2

2

13

Small-scale

0.533

High

826420

SMC6
Structural maintenance of chromosomes protein 6

1

11

Small-scale

0.515

High

644663

MAG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.513

High

817307

KRE29
DNA repair protein KRE29

1

0

Small-scale

0.493

High

416551

HXKB
Hexokinase-2

1

1

Small-scale

0.481

High

547873

NHP6B
Non-histone chromosomal protein 6B

1

20

Small-scale

0.481

High

557726

SRS2
ATP-dependent DNA helicase SRS2

1

3

Small-scale

0.481

High

575958

CYPH
Peptidyl-prolyl cis-trans isomerase

1

12

Small-scale

0.481

High

585960

CSK21
Casein kinase II subunit alpha

1

12

Small-scale

0.481

High

596932

PDC5
Pyruvate decarboxylase isozyme 2

1

1

Small-scale

0.481

High

649501

UBA1
Ubiquitin-activating enzyme E1 1

1

2

Small-scale

0.481

High

826394

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

7

High-throughput

0.481

High

826412

NCBP2
Nuclear cap-binding protein subunit 2

1

17

Small-scale

0.481

High

826414

ELG1
Telomere length regulation protein ELG1

1

2

Small-scale

0.481

High

381135

H2B1
Histone H2B.1

1

7

High-throughput

0.479

High

381537

H2B2
Histone H2B.2

1

7

High-throughput

0.479

High

382152

H4
Histone H4

1

8

High-throughput

0.479

High

415228

TOP1
DNA topoisomerase 1

1

6

High-throughput

0.479

High

454522

PIF1
ATP-dependent DNA helicase PIF1

1

2

High-throughput

0.479

High

475125

CYAA
Adenylate cyclase

1

3

High-throughput

0.479

High

642054

DPOE
DNA polymerase epsilon catalytic subunit A

1

2

High-throughput

0.479

High

672017

MSH3
DNA mismatch repair protein MSH3

1

3

High-throughput

0.479

High

682921

MSH2
DNA mismatch repair protein MSH2

1

3

High-throughput

0.479

High

707333

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

735388

MCM10
Minichromosome maintenance protein 10

1

1

High-throughput

0.479

High

743033

SWI3
SWI/SNF complex subunit SWI3

1

6

High-throughput

0.479

High

745773

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

5

High-throughput

0.479

High

801000

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.479

High

812172

FKHL1
Pre-rRNA-processing protein FHL1

1

13

High-throughput

0.479

High

826383

FKH2
Fork head protein homolog 2

1

11

High-throughput

0.479

High

826384

CHA4
Activatory protein CHA4

1

3

High-throughput

0.479

High

826393

CDC14
Tyrosine-protein phosphatase CDC14

1

9

Small-scale

0.479

High

826395

PDR12
ATP-dependent permease PDR12

1

1

High-throughput

0.479

High

826401

TRI1
Protein TRI1

1

1

High-throughput

0.479

High

826402

ARP9
Actin-like protein ARP9

1

7

High-throughput

0.479

High

826415

CFT2
Cleavage factor two protein 2

1

3

High-throughput

0.479

High

781842

SPO14
Phospholipase D1

1

0

High-throughput

0.460

High

534188

PCKA
Phosphoenolpyruvate carboxykinase

1

0

High-throughput

0.458

High

653795

APN1
Apurinic-apyrimidinic endonuclease 1

1

0

High-throughput

0.458

High

757987

SEF1
Putative transcription factor SEF1

1

0

High-throughput

0.458

High

817678

DOT6
Transcriptional regulatory protein DOT6

1

0

High-throughput

0.458

High

826388

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.458

High

826406

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.458

High

826416

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

826417

IES3
Ino eighty subunit 3

1

0

High-throughput

0.458

High

392866

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

526903

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

545182

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.445

High

741746

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

752358

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

434257

RL29
Large ribosomal subunit protein eL29

1

2

Small-scale

0.439

High

655580

TKT1
Transketolase 1

1

3

Small-scale

0.439

High

807192

IF1A
Eukaryotic translation initiation factor 1A

1

1

Small-scale

0.439

High

807892

BFR1
Nuclear segregation protein BFR1

1

1

Small-scale

0.439

High

826396

COFI
Cofilin

1

1

Small-scale

0.439

High

567687

ACOX
Acyl-coenzyme A oxidase

1

5

High-throughput

0.437

High

677439

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

745161

CACP
Carnitine O-acetyltransferase, mitochondrial

1

4

High-throughput

0.437

High

751153

SFC1
Succinate/fumarate mitochondrial transporter

1

7

High-throughput

0.437

High

806293

KOG1
Target of rapamycin complex 1 subunit KOG1

1

9

High-throughput

0.437

High

817108

YAT2
Carnitine O-acetyltransferase YAT2

1

4

High-throughput

0.437

High

826390

YG5B
Uncharacterized RNA-binding protein YGR250C

1

8

High-throughput

0.437

High

826392

CACM
Putative mitochondrial carnitine O-acetyltransferase

1

4

High-throughput

0.437

High

826399

TMA64
Translation machinery-associated protein 64

1

1

High-throughput

0.437

High

826403

FCF1
rRNA-processing protein FCF1

1

1

High-throughput

0.437

High

826405

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

20

High-throughput

0.437

High

826407

REH1
Cytoplasmic 60S subunit biogenesis factor REH1

1

2

High-throughput

0.437

High

826411

FDH1
Formate dehydrogenase 1

1

3

High-throughput

0.437

High

736662

ASF1
Histone chaperone ASF1

1

0

High-throughput

0.426

High

826421

CENPX
Inner kinetochore subunit MHF2

5

0

Small-scale

0.370

High

826422

CENPS
Inner kinetochore subunit MHF1

4

0

Small-scale

0.367

High

736560

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

3

0

Small-scale

0.334

High

688800

RFA3
Replication factor A protein 3

2

0

Small-scale

0.305

High

594957

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

Small-scale

0.251

Low

782354

RPF2
Ribosome biogenesis protein RPF2

1

0

Small-scale

0.251

Low

826385

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.251

Low

826400

ECM18
Protein ECM18

1

0

Small-scale

0.251

Low

677145

LRE1
Laminarase-resistance protein LRE1

1

0

High-throughput

0.249

Low

751548

DHE2
NAD-specific glutamate dehydrogenase

1

0

High-throughput

0.249

Low

823203

ATF1
Alcohol O-acetyltransferase 1

1

0

High-throughput

0.249

Low

823426

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.249

Low

826386

IML1
Vacuolar membrane-associated protein IML1

1

0

High-throughput

0.249

Low

826391

VAC7
Vacuolar segregation protein 7

1

0

High-throughput

0.249

Low

826404

RGC1
Regulator of the glycerol channel 1

1

0

High-throughput

0.249

Low

826408

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.249

Low

826413

AIM41
Altered inheritance of mitochondria protein 41, mitochondrial

1

0

High-throughput

0.249

Low

826418

YD041
Putative uncharacterized protein YDL041W

1

0

High-throughput

0.238

Low

826398

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025