Protein: SIN3
Transcriptional regulatory protein SIN3

Gene: SIN3
Organism: Saccharomyces cerevisiae S288C
Interactions: 164
UniProt ID: P22579

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

649933

RPD3
Histone deacetylase RPD3

23

19

Small-scale

0.989

High

650018

RCO1
Transcriptional regulatory protein RCO1

13

20

Small-scale

0.979

High

649990

PHO23
Transcriptional regulatory protein PHO23

11

5

Small-scale

0.974

High

650039

EAF3
Chromatin modification-related protein EAF3

10

5

Small-scale

0.970

High

649974

SDS3
Transcriptional regulatory protein SDS3

12

0

Small-scale

0.926

High

649956

RXT2
Transcriptional regulatory protein RXT2

10

0

Small-scale

0.919

High

649957

SAP30
Transcriptional regulatory protein SAP30

9

0

Small-scale

0.918

High

649928

DEP1
Transcriptional regulatory protein DEP1

6

0

Small-scale

0.878

High

650001

H3
Histone H3

4

5

Small-scale

0.873

High

419604

H2A2
Histone H2A.2

3

1

High-throughput

0.848

High

649911

SIN3
Transcriptional regulatory protein SIN3

3

3

Small-scale

0.827

High

598372

TUP1
General transcriptional corepressor TUP1

2

4

High-throughput

0.802

High

650030

CTI6
Histone deacetylase complex subunit CTI6

11

3

Small-scale

0.754

High

381407

H2B2
Histone H2B.2

2

2

High-throughput

0.737

High

650011

UME1
Transcriptional regulatory protein UME1

12

0

Small-scale

0.723

High

642168

OPI1
Transcriptional repressor OPI1

7

0

Small-scale

0.714

High

650023

RXT3
Transcriptional regulatory protein RXT3

7

0

Small-scale

0.709

High

649962

UME6
Transcriptional regulatory protein UME6

6

0

Small-scale

0.702

High

523092

HSP71
Heat shock protein SSA1

5

3

High-throughput

0.695

High

649947

ASH1
Transcriptional regulatory protein ASH1

6

0

Small-scale

0.686

High

649998

HDA1
Histone deacetylase HDA1

1

19

Small-scale

0.680

High

650035

HOS1
Histone deacetylase HOS1

1

19

Small-scale

0.680

High

649972

FKH1
Fork head protein homolog 1

3

5

Small-scale

0.669

High

649955

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

3

15

High-throughput

0.657

High

649981

RSC8
Chromatin structure-remodeling complex protein RSC8

3

4

High-throughput

0.657

High

381882

H4
Histone H4

3

2

High-throughput

0.650

High

543851

SSB1
Ribosome-associated molecular chaperone SSB1

3

3

High-throughput

0.650

High

650009

IMA1
Importin subunit alpha

3

0

High-throughput

0.629

High

649923

FUN19
SWIRM domain-containing protein FUN19

3

0

High-throughput

0.622

High

585857

CSK21
Casein kinase II subunit alpha

2

3

High-throughput

0.621

High

622872

CSK22
Casein kinase II subunit alpha'

2

3

High-throughput

0.621

High

650008

ABF2
ARS-binding factor 2, mitochondrial

2

7

High-throughput

0.621

High

380974

H2B1
Histone H2B.1

1

2

High-throughput

0.618

High

649953

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.618

High

650041

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.618

High

649973

XBP1
Transcriptional repressor XBP1

3

0

Small-scale

0.613

High

649952

STB6
Protein STB6

2

1

Small-scale

0.594

High

454401

PHO4
Phosphate system positive regulatory protein PHO4

2

0

Small-scale

0.592

High

649984

STB2
Protein STB2

2

1

Small-scale

0.590

High

650025

CDC45
Cell division control protein 45

2

0

High-throughput

0.576

High

649954

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

2

High-throughput

0.575

High

650010

HOS3
Histone deacetylase HOS3

1

20

High-throughput

0.575

High

649925

BMH1
Protein BMH1

2

1

High-throughput

0.571

High

649977

HAC1
Transcriptional activator HAC1

2

0

Small-scale

0.569

High

649979

STB1
Protein STB1

2

0

Small-scale

0.565

High

650043

MTR10
mRNA transport regulator MTR10

2

0

High-throughput

0.563

High

525951

HSP72
Heat shock protein SSA2

2

3

High-throughput

0.552

High

649934

HSP7F
Heat shock protein homolog SSE1

2

4

High-throughput

0.552

High

649978

FKH2
Fork head protein homolog 2

1

5

High-throughput

0.536

High

650013

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.536

High

649966

IFH1
Protein IFH1

1

1

High-throughput

0.515

High

650016

HMO1
High mobility group protein 1

1

5

High-throughput

0.515

High

649958

STB5
Protein STB5

1

2

Small-scale

0.508

High

649969

LSM4
LSM complex subunit LSM4

1

1

High-throughput

0.508

High

649914

ROX1
Repressor ROX1

1

7

Small-scale

0.501

High

649945

YOX1
Homeobox protein YOX1

1

1

Small-scale

0.501

High

650017

YHP1
Homeobox protein YHP1

1

3

Small-scale

0.501

High

649963

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

650033

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.493

High

649988

STB4
Probable transcriptional regulatory protein STB4

1

0

Small-scale

0.486

High

650004

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

0

High-throughput

0.486

High

650038

STB3
Protein STB3

1

0

Small-scale

0.486

High

649919

DAL80
Nitrogen regulatory protein DAL80

1

0

Small-scale

0.480

High

649921

INO2
Protein INO2

1

0

Small-scale

0.480

High

649999

MOT3
Transcriptional activator/repressor MOT3

1

0

Small-scale

0.480

High

650029

RDR1
Protein RDR1

1

0

Small-scale

0.480

High

650037

WHI5
G1-specific transcriptional repressor WHI5

1

0

Small-scale

0.480

High

649938

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

649997

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

650031

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

594194

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

632404

CG12
G1/S-specific cyclin CLN2

1

0

Small-scale

0.458

High

649924

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

649926

MEI4
Meiosis-specific protein MEI4

1

0

High-throughput

0.458

High

649931

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

649940

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

649949

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

649950

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

649976

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

649989

TAF4
Transcription initiation factor TFIID subunit 4

1

0

High-throughput

0.458

High

650020

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

650026

SGO1
Shugoshin

1

0

High-throughput

0.458

High

650032

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

650034

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

650042

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

392251

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

504650

YP14B
Transposon Ty1-PR3 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

649912

MCM3
DNA replication licensing factor MCM3

1

1

High-throughput

0.445

High

649917

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

649927

MCM5
Minichromosome maintenance protein 5

1

1

High-throughput

0.445

High

649930

BTAF1
TATA-binding protein-associated factor MOT1

1

17

High-throughput

0.445

High

649935

STH1
Nuclear protein STH1/NPS1

1

15

High-throughput

0.445

High

649936

CHD1
Chromo domain-containing protein 1

1

12

High-throughput

0.445

High

649941

TFC4
Transcription factor tau 131 kDa subunit

1

1

High-throughput

0.445

High

649942

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

649943

IXR1
Intrastrand cross-link recognition protein

1

3

High-throughput

0.445

High

649948

SPT7
SAGA complex subunit SPT7

1

12

High-throughput

0.445

High

649965

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

649970

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

650000

ACT
Actin

1

1

High-throughput

0.445

High

650002

ARP4
Actin-related protein 4

1

3

High-throughput

0.445

High

650003

CDC14
Tyrosine-protein phosphatase CDC14

1

1

High-throughput

0.445

High

650006

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

8

High-throughput

0.445

High

650007

ADA2
SAGA complex subunit ADA2

1

4

High-throughput

0.445

High

650014

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

2

High-throughput

0.445

High

650015

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.445

High

650019

ARP9
Actin-like protein ARP9

1

3

High-throughput

0.445

High

650028

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

16

High-throughput

0.445

High

650040

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.445

High

649996

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

649939

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

649913

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.426

High

649918

RSC6
Chromatin structure-remodeling complex protein RSC6

1

0

High-throughput

0.426

High

649922

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

649932

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.426

High

649937

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.426

High

649960

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.426

High

649961

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.426

High

649968

DOT6
Transcriptional regulatory protein DOT6

1

0

High-throughput

0.426

High

649971

ATAD2
ATPase histone chaperone YTA7

1

0

High-throughput

0.426

High

649983

SUM1
Suppressor of mar1-1 protein

1

0

High-throughput

0.426

High

649985

NET1
Nucleolar protein NET1

1

0

High-throughput

0.426

High

649987

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.426

High

649991

MCM6
DNA replication licensing factor MCM6

1

0

High-throughput

0.426

High

649992

ITC1
Imitation switch two complex protein 1

1

0

High-throughput

0.426

High

649994

H1
Histone H1

1

0

High-throughput

0.426

High

650012

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.426

High

650022

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.426

High

650024

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.426

High

453428

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.407

High

649915

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.407

High

649929

EF2
Elongation factor 2

1

2

High-throughput

0.407

High

649975

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.407

High

649995

JJJ1
J protein JJJ1

1

1

High-throughput

0.407

High

649980

IOC3
ISWI one complex protein 3

2

0

High-throughput

0.324

High

649982

CSK2B
Casein kinase II subunit beta

2

0

High-throughput

0.324

High

649964

TCPD
T-complex protein 1 subunit delta

2

0

High-throughput

0.307

High

649946

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

0

High-throughput

0.282

High

650021

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.269

Low

94535

STE2
Pheromone alpha factor receptor

1

0

High-throughput

0.251

Low

649993

MPS2
Monopolar spindle protein 2

1

0

Small-scale

0.251

Low

149593

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

383525

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

409943

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433456

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

435780

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

441714

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

502858

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504044

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

512265

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

512829

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514465

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

649916

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

649920

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

649944

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

649951

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

649959

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

649967

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

649986

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

650005

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

650027

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

386575

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

650036

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025