Protein: SSN2
Mediator of RNA polymerase II transcription subunit 13 (Mediator complex subunit 13) (Protein SCA1) (Suppressor of RNA polymerase B SSN2)

Gene: SSN2
Organism: Saccharomyces cerevisiae S288C
Interactions: 151
UniProt ID: P38931

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003713 - transcription coactivator activity
GO:0016592 - mediator complex
GO:0030332 - cyclin binding
GO:0045944 - positive regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

807825

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

7

0

Small-scale

0.715

High

807803

SSN3
Meiotic mRNA stability protein kinase SSN3

6

0

Small-scale

0.702

High

740406

MED17
Mediator of RNA polymerase II transcription subunit 17

6

0

Small-scale

0.699

High

678809

SRB8
Mediator of RNA polymerase II transcription subunit 12

5

0

Small-scale

0.684

High

807853

MED7
Mediator of RNA polymerase II transcription subunit 7

5

0

Small-scale

0.684

High

740796

MED18
Mediator of RNA polymerase II transcription subunit 18

5

0

Small-scale

0.678

High

740457

MED22
Mediator of RNA polymerase II transcription subunit 22

3

0

High-throughput

0.634

High

807826

MED21
Mediator of RNA polymerase II transcription subunit 21

3

0

Small-scale

0.628

High

807830

MED5
Mediator of RNA polymerase II transcription subunit 5

3

0

Small-scale

0.628

High

668488

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

High-throughput

0.616

High

807856

MED2
Mediator of RNA polymerase II transcription subunit 2

3

0

High-throughput

0.616

High

619429

MED14
Mediator of RNA polymerase II transcription subunit 14

2

0

High-throughput

0.585

High

733540

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.585

High

807860

MED1
Mediator of RNA polymerase II transcription subunit 1

2

0

High-throughput

0.585

High

807849

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

Small-scale

0.569

High

807862

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

Small-scale

0.569

High

801148

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

High-throughput

0.547

High

801826

KSP1
Serine/threonine-protein kinase KSP1

2

1

Small-scale

0.535

High

523934

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.504

High

628333

SFL1
Flocculation suppression protein

1

0

Small-scale

0.493

High

797705

MED8
Mediator of RNA polymerase II transcription subunit 8

1

1

High-throughput

0.479

High

452737

ADR1
Regulatory protein ADR1

1

0

Small-scale

0.458

High

615015

GLN3
Nitrogen regulatory protein GLN3

1

0

Small-scale

0.458

High

624912

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

High-throughput

0.458

High

694203

BUD14
Bud site selection protein 14

1

0

Small-scale

0.458

High

751207

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.458

High

757582

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.458

High

804018

MED6
Mediator of RNA polymerase II transcription subunit 6

1

0

High-throughput

0.458

High

807812

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

High-throughput

0.458

High

807866

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

748843

SWE1
Mitosis inhibitor protein kinase SWE1

1

1

High-throughput

0.457

High

807852

ATG20
Autophagy-related protein 20

1

1

Small-scale

0.439

High

454214

LEUC
3-isopropylmalate dehydratase

1

1

Small-scale

0.437

High

560604

KIN1
Serine/threonine protein kinase KIN1

1

1

Small-scale

0.437

High

583748

DAL5
Allantoate permease

1

1

Small-scale

0.437

High

584363

GCN2
eIF-2-alpha kinase GCN2

1

1

Small-scale

0.437

High

585935

CSK21
Casein kinase II subunit alpha

1

1

Small-scale

0.437

High

618871

GAP1
General amino-acid permease GAP1

1

1

Small-scale

0.437

High

622359

ACON
Aconitate hydratase, mitochondrial

1

1

Small-scale

0.437

High

622951

CSK22
Casein kinase II subunit alpha'

1

1

Small-scale

0.437

High

673422

AGP1
General amino acid permease AGP1

1

1

Small-scale

0.437

High

778935

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

1

Small-scale

0.437

High

790443

PAM1
Protein PAM1

1

1

Small-scale

0.437

High

807758

CSK2C
Casein kinase II subunit beta'

1

1

Small-scale

0.437

High

807806

SAP1
Protein SAP1

1

1

Small-scale

0.437

High

807819

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.437

High

807834

CA120
CCR4-NOT transcriptional complex subunit CAF120

1

1

Small-scale

0.437

High

807839

SVL3
Styryl dye vacuolar localization protein 3

1

1

Small-scale

0.437

High

807850

SKG3
Protein SKG3

1

1

Small-scale

0.437

High

807855

RTK1
Probable serine/threonine-protein kinase RTK1

1

1

Small-scale

0.437

High

807857

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.426

High

526682

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

741572

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

454574

TFS2
Transcription elongation factor S-II

2

0

Small-scale

0.323

High

807833

CAF40
Protein CAF40

2

0

Small-scale

0.313

High

666683

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

2

0

Small-scale

0.304

High

726211

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

Small-scale

0.299

High

781869

CAF4
CCR4-associated factor 4

1

0

Small-scale

0.299

High

438141

NOT2
General negative regulator of transcription subunit 2

1

0

Small-scale

0.288

High

678957

NOT1
General negative regulator of transcription subunit 1

1

0

Small-scale

0.288

High

807809

EDC3
Enhancer of mRNA-decapping protein 3

1

0

Small-scale

0.288

High

807823

SNX4
Sorting nexin-4

1

0

Small-scale

0.288

High

807859

GLE1
mRNA export factor GLE1

1

0

Small-scale

0.288

High

804696

HTD2
Hydroxyacyl-thioester dehydratase type 2, mitochondrial

1

0

High-throughput

0.269

Low

807802

POP2
Poly(A) ribonuclease POP2

1

0

Small-scale

0.265

Low

807818

CAF16
CCR4-associated factor 16

1

0

Small-scale

0.265

Low

437922

KAPC
cAMP-dependent protein kinase type 3

1

0

High-throughput

0.261

Low

448721

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.261

Low

725917

PSK1
Serine/threonine-protein kinase PSK1

1

0

Small-scale

0.251

Low

807804

DHH1
ATP-dependent RNA helicase DHH1

1

0

Small-scale

0.251

Low

401999

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.249

Low

439129

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

Small-scale

0.249

Low

439333

PDC1
Pyruvate decarboxylase isozyme 1

1

0

Small-scale

0.249

Low

450588

FAS1
Fatty acid synthase subunit beta

1

0

Small-scale

0.249

Low

475121

CYAA
Adenylate cyclase

1

0

Small-scale

0.249

Low

555074

G6PI
Glucose-6-phosphate isomerase

1

0

Small-scale

0.249

Low

572577

ALF
Fructose-bisphosphate aldolase

1

0

Small-scale

0.249

Low

579377

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

603054

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.249

Low

617980

IRA1
Inhibitory regulator protein IRA1

1

0

Small-scale

0.249

Low

668267

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

Small-scale

0.249

Low

679671

CDC48
Cell division control protein 48

1

0

Small-scale

0.249

Low

693490

CBPS
Carboxypeptidase S

1

0

Small-scale

0.249

Low

698142

KRE2
Glycolipid 2-alpha-mannosyltransferase

1

0

Small-scale

0.249

Low

701524

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

0

Small-scale

0.249

Low

701594

UBC8
Ubiquitin-conjugating enzyme E2-24 kDa

1

0

Small-scale

0.249

Low

704895

KIP2
Kinesin-like protein KIP2

1

0

Small-scale

0.249

Low

707081

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

732144

COPG
Coatomer subunit gamma

1

0

Small-scale

0.249

Low

736182

YBT1
ATP-dependent bile acid permease

1

0

Small-scale

0.249

Low

737267

HXT3
Low-affinity glucose transporter HXT3

1

0

Small-scale

0.249

Low

737456

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

Small-scale

0.249

Low

739508

DUR1
Urea amidolyase [Includes: Urea carboxylase

1

0

Small-scale

0.249

Low

740298

PAH1
Phosphatidic acid phosphohydrolase 1

1

0

Small-scale

0.249

Low

740915

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.249

Low

745000

YSC84
Protein YSC84

1

0

Small-scale

0.249

Low

745183

CDC13
Cell division control protein 13

1

0

Small-scale

0.249

Low

747090

PTR2
Peptide transporter PTR2

1

0

Small-scale

0.249

Low

748618

STE5
Protein STE5

1

0

Small-scale

0.249

Low

758213

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

Small-scale

0.249

Low

764070

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

779035

LTHAD
L-threo-3-hydroxyaspartate ammonia-lyase

1

0

Small-scale

0.249

Low

792655

AP2A
AP-2 complex subunit alpha

1

0

Small-scale

0.249

Low

795636

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

Small-scale

0.249

Low

796056

DSF2
Protein DSF2

1

0

Small-scale

0.249

Low

796801

EXO84
Exocyst complex component EXO84

1

0

Small-scale

0.249

Low

798033

YB75
Uncharacterized protein YBR225W

1

0

Small-scale

0.249

Low

800702

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.249

Low

805252

SBE22
Protein SBE22

1

0

Small-scale

0.249

Low

807801

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

0

Small-scale

0.249

Low

807805

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.249

Low

807807

BEM2
GTPase-activating protein BEM2/IPL2

1

0

Small-scale

0.249

Low

807808

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

0

Small-scale

0.249

Low

807810

YAT2
Carnitine O-acetyltransferase YAT2

1

0

Small-scale

0.249

Low

807811

DOT6
Transcriptional regulatory protein DOT6

1

0

Small-scale

0.249

Low

807813

MET18
DNA repair/transcription protein MET18/MMS19

1

0

Small-scale

0.249

Low

807814

PRP17
Pre-mRNA-processing factor 17

1

0

Small-scale

0.249

Low

807815

FKS2
1,3-beta-glucan synthase component GSC2

1

0

Small-scale

0.249

Low

807816

VATH
V-type proton ATPase subunit H

1

0

Small-scale

0.249

Low

807817

BNI1
Protein BNI1

1

0

Small-scale

0.249

Low

807820

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

Small-scale

0.249

Low

807821

FYV8
Protein FYV8

1

0

Small-scale

0.249

Low

807822

BNA3
Probable kynurenine--oxoglutarate transaminase BNA3

1

0

Small-scale

0.249

Low

807824

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

Small-scale

0.249

Low

807827

YG51
Uncharacterized protein YGR237C

1

0

Small-scale

0.249

Low

807828

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.249

Low

807829

ACS2
Acetyl-coenzyme A synthetase 2

1

0

Small-scale

0.249

Low

807831

PALF
pH-response regulator protein palF/RIM8

1

0

Small-scale

0.249

Low

807832

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

0

Small-scale

0.249

Low

807835

VPS75
Vacuolar protein sorting-associated protein 75

1

0

Small-scale

0.249

Low

807836

SQS1
Protein SQS1

1

0

Small-scale

0.249

Low

807837

SFB2
SED5-binding protein 2

1

0

Small-scale

0.249

Low

807838

ORC1
Origin recognition complex subunit 1

1

0

Small-scale

0.249

Low

807840

YD239
Uncharacterized protein YDR239C

1

0

Small-scale

0.249

Low

807841

WDR59
Maintenance of telomere capping protein 5

1

0

Small-scale

0.249

Low

807842

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

807843

SND1
SRP-independent targeting protein 1

1

0

Small-scale

0.249

Low

807844

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.249

Low

807845

ERB1
Ribosome biogenesis protein ERB1

1

0

Small-scale

0.249

Low

807846

RQC1
Ribosome quality control complex subunit 1

1

0

Small-scale

0.249

Low

807847

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.249

Low

807848

MSC3
Meiotic sister-chromatid recombination protein 3

1

0

Small-scale

0.249

Low

807851

ATG17
Autophagy-related protein 17

1

0

Small-scale

0.249

Low

807854

NUR1
Nuclear rim protein 1

1

0

Small-scale

0.249

Low

807858

CRM2
Homeostatic regulator of DAG

1

0

Small-scale

0.249

Low

807861

HSP42
Heat shock protein 42

1

0

Small-scale

0.249

Low

807863

CAF1A
Chromatin assembly factor 1 subunit A

1

0

Small-scale

0.249

Low

807864

AVL9
Late secretory pathway protein AVL9

1

0

Small-scale

0.249

Low

807865

RQC2
Ribosome quality control complex subunit 2

1

0

Small-scale

0.249

Low

544856

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.232

Low

752254

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025