Protein: GIS1
Transcriptional activator/repressor GIS1

Gene: GIS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 210
UniProt ID: Q03833

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1044137

GIS1
Transcriptional activator/repressor GIS1

2

14

Small-scale

0.744

High

393262

HSP82
ATP-dependent molecular chaperone HSP82

3

3

High-throughput

0.633

High

617953

YPK2
Serine/threonine-protein kinase YPK2/YKR2

1

2

High-throughput

0.618

High

697394

MIG1
Regulatory protein MIG1

1

17

High-throughput

0.618

High

815631

MIG3
Transcription corepressor MIG3

1

18

High-throughput

0.618

High

448791

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.586

High

656862

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.586

High

708067

TF2B
Transcription initiation factor IIB

2

1

High-throughput

0.584

High

381618

H2B2
Histone H2B.2

2

9

High-throughput

0.571

High

1044175

RUVB2
RuvB-like protein 2

2

1

High-throughput

0.571

High

660814

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

7

Small-scale

0.561

High

1030249

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

4

High-throughput

0.553

High

1044162

HRK1
Serine/threonine-protein kinase HRK1

1

2

High-throughput

0.553

High

1044167

RTK1
Probable serine/threonine-protein kinase RTK1

1

2

High-throughput

0.553

High

1044151

JIP5
WD repeat-containing protein JIP5

1

4

Small-scale

0.552

High

546123

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.536

High

722227

XPO1
Exportin-1

1

9

High-throughput

0.536

High

1043900

TAF8
Transcription initiation factor TFIID subunit 8

1

0

Small-scale

0.529

High

1044152

PIN3
[PSI+] inducibility protein 3

1

0

High-throughput

0.518

High

763290

SGS1
ATP-dependent helicase SGS1

1

1

Small-scale

0.481

High

1044172

SIZ2
E3 SUMO-protein ligase SIZ2

1

2

Small-scale

0.481

High

359524

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

High-throughput

0.479

High

366837

IPYR
Inorganic pyrophosphatase

1

2

High-throughput

0.479

High

452961

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

475139

CYAA
Adenylate cyclase

1

3

High-throughput

0.479

High

486296

TBA1
Tubulin alpha-1 chain

1

4

High-throughput

0.479

High

576003

CYPH
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.479

High

676974

SRO9
RNA-binding protein SRO9

1

1

High-throughput

0.479

High

741095

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

3

High-throughput

0.479

High

757636

SIP2
SNF1 protein kinase subunit beta-2

1

1

High-throughput

0.479

High

757795

TOD6
Transcriptional regulatory protein TOD6

1

1

High-throughput

0.479

High

761137

NOT4
General negative regulator of transcription subunit 4

1

2

High-throughput

0.479

High

776495

MPE1
Protein MPE1

1

1

High-throughput

0.479

High

780164

SDS22
Protein phosphatase 1 regulatory subunit SDS22

1

3

High-throughput

0.479

High

792445

BOI1
BEM1-interacting protein 1

1

1

High-throughput

0.479

High

800883

GUAA
GMP synthase [glutamine-hydrolyzing]

1

2

High-throughput

0.479

High

802800

OSH3
Oxysterol-binding protein homolog 3

1

1

High-throughput

0.479

High

808901

UME6
Transcriptional regulatory protein UME6

1

1

High-throughput

0.479

High

814263

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.479

High

815845

BEM2
GTPase-activating protein BEM2/IPL2

1

9

High-throughput

0.479

High

817684

DOT6
Transcriptional regulatory protein DOT6

1

1

High-throughput

0.479

High

825118

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

1

High-throughput

0.479

High

825475

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

845938

BRE2
COMPASS component BRE2

1

3

High-throughput

0.479

High

850425

ATG18
Autophagy-related protein 18

1

4

High-throughput

0.479

High

850618

IRC5
Uncharacterized ATP-dependent helicase IRC5

1

12

High-throughput

0.479

High

874337

HOSC
Homocitrate synthase, cytosolic isozyme

1

1

High-throughput

0.479

High

918202

NMA2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

1

1

High-throughput

0.479

High

919433

PBP1
PAB1-binding protein 1

1

1

High-throughput

0.479

High

923193

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.479

High

923790

GOR1
Glyoxylate reductase 1

1

4

High-throughput

0.479

High

923869

GIS2
Zinc finger protein GIS2

1

4

High-throughput

0.479

High

948641

ACT
Actin

1

1

High-throughput

0.479

High

1024982

2ABA
Protein phosphatase PP2A regulatory subunit B

1

2

Small-scale

0.479

High

1044141

AGE1
ADP-ribosylation factor GTPase-activating protein effector protein 1

1

1

High-throughput

0.479

High

1044145

GAL83
SNF1 protein kinase subunit beta-3

1

1

High-throughput

0.479

High

1044147

RTN1
Reticulon-like protein 1

1

2

High-throughput

0.479

High

1044149

NMA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

1

High-throughput

0.479

High

1044155

PBP4
Protein PBP4

1

1

High-throughput

0.479

High

1044168

HOSM
Homocitrate synthase, mitochondrial

1

1

High-throughput

0.479

High

1044177

YP247
WD repeat-containing protein YPL247C

1

11

High-throughput

0.479

High

739092

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

1

0

Small-scale

0.460

High

817241

ZRG8
Zinc-regulated protein 8

1

0

Small-scale

0.460

High

827047

MGA2
Protein MGA2

1

0

Small-scale

0.460

High

836657

GLDS1
Protein GDS1

1

0

Small-scale

0.460

High

924964

NIS1
Protein NIS1

1

0

Small-scale

0.460

High

1044144

CSM3
Chromosome segregation in meiosis protein 3

1

0

Small-scale

0.460

High

1044166

BMS1
Ribosome biogenesis protein BMS1

1

0

Small-scale

0.460

High

365691

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

368190

THDH
Threonine dehydratase, mitochondrial

1

0

High-throughput

0.458

High

452684

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.458

High

453995

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.458

High

459156

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.458

High

514817

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

553928

WHI2
Growth regulation protein

1

0

High-throughput

0.458

High

555148

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

557031

AAKG
5'-AMP-activated protein kinase subunit gamma

1

0

High-throughput

0.458

High

598338

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.458

High

607471

GLRX2
Glutaredoxin-2

1

0

High-throughput

0.458

High

632822

DBP5
ATP-dependent RNA helicase DBP5

1

0

High-throughput

0.458

High

633270

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

High-throughput

0.458

High

638040

UTR1
NAD(+) kinase

1

0

High-throughput

0.458

High

638115

OSM1
Fumarate reductase 2

1

0

High-throughput

0.458

High

651984

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

High-throughput

0.458

High

664347

SSD1
Protein SSD1

1

0

High-throughput

0.458

High

668950

ERG6
Sterol 24-C-methyltransferase ERG6

1

0

High-throughput

0.458

High

670204

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

672560

RM32
Large ribosomal subunit protein bL32m

1

0

High-throughput

0.458

High

677893

DPO4
DNA polymerase IV

1

0

High-throughput

0.458

High

693521

PUR7
Phosphoribosylaminoimidazole-succinocarboxamide synthase

1

0

High-throughput

0.458

High

699533

NAM9
Small ribosomal subunit protein uS4m

1

0

High-throughput

0.458

High

732037

MLF3
Protein MLF3

1

0

High-throughput

0.458

High

740430

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.458

High

740529

SIP1
SNF1 protein kinase subunit beta-1

1

0

High-throughput

0.458

High

751001

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

High-throughput

0.458

High

780982

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.458

High

789841

YC16
UPF0743 protein YCR087C-A

1

0

High-throughput

0.458

High

797204

OPY1
Pleckstrin homology domain protein OPY1

1

0

High-throughput

0.458

High

798184

RMD9L
RNA-binding protein RMD9-like, mitochondrial

1

0

High-throughput

0.458

High

802765

RRP3
ATP-dependent rRNA helicase RRP3

1

0

High-throughput

0.458

High

805156

YHP7
Uncharacterized protein YHR097C

1

0

High-throughput

0.458

High

813654

NUP60
Nucleoporin NUP60

1

0

High-throughput

0.458

High

816094

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

0

High-throughput

0.458

High

816112

HPA3
D-amino-acid N-acetyltransferase HPA3

1

0

High-throughput

0.458

High

822242

SOK1
Protein SOK1

1

0

High-throughput

0.458

High

825977

GVP36
Protein GVP36

1

0

High-throughput

0.458

High

827022

INA22
Inner membrane assembly complex subunit 22

1

0

High-throughput

0.458

High

836641

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

0

High-throughput

0.458

High

863395

HIT1
Protein HIT1

1

0

High-throughput

0.458

High

865637

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

893054

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

915013

ALAT1
Alanine aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

923003

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

932277

MOT3
Transcriptional activator/repressor MOT3

1

0

High-throughput

0.458

High

1040660

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.458

High

1040718

MSC1
Meiotic sister chromatid recombination protein 1

1

0

High-throughput

0.458

High

1043350

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

1044139

SNX41
Sorting nexin-41

1

0

High-throughput

0.458

High

1044142

HFD1
Fatty aldehyde dehydrogenase HFD1

1

0

High-throughput

0.458

High

1044146

RNH1
Ribonuclease H

1

0

High-throughput

0.458

High

1044160

TMC1
AN1-type zinc finger protein TMC1

1

0

High-throughput

0.458

High

1044161

GYP1
GTPase-activating protein GYP1

1

0

High-throughput

0.458

High

1044164

VTS1
RNA-binding protein VTS1

1

0

High-throughput

0.458

High

1044170

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

1044171

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1044174

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.458

High

1044176

KCS1
Inositol hexakisphosphate kinase 1

1

0

High-throughput

0.458

High

1044179

COA6
Cytochrome c oxidase assembly factor 6

1

0

High-throughput

0.458

High

1044180

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

382311

H4
Histone H4

1

5

High-throughput

0.445

High

525024

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

527576

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

614845

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

1

High-throughput

0.445

High

671697

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.445

High

713033

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.445

High

713298

MCM5
Minichromosome maintenance protein 5

1

9

High-throughput

0.445

High

742312

HSP7F
Heat shock protein homolog SSE1

1

16

High-throughput

0.445

High

743050

SWI3
SWI/SNF complex subunit SWI3

1

10

High-throughput

0.445

High

743129

STH1
Nuclear protein STH1/NPS1

1

9

High-throughput

0.445

High

752681

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

793987

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

6

High-throughput

0.445

High

794213

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

10

High-throughput

0.445

High

850566

RSC8
Chromatin structure-remodeling complex protein RSC8

1

4

High-throughput

0.445

High

917058

MCM6
DNA replication licensing factor MCM6

1

9

High-throughput

0.445

High

963692

H3
Histone H3

1

20

High-throughput

0.445

High

1010204

ARP4
Actin-related protein 4

1

2

High-throughput

0.445

High

1026818

CDC14
Tyrosine-protein phosphatase CDC14

1

3

High-throughput

0.445

High

1044138

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.445

High

1044140

SXM1
Importin beta SMX1

1

12

High-throughput

0.445

High

1044150

FKBP4
FK506-binding protein 4

1

2

High-throughput

0.445

High

1044153

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

20

High-throughput

0.445

High

1044163

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

11

High-throughput

0.445

High

1044178

H2AZ
Histone H2A.Z

1

3

High-throughput

0.445

High

1042478

JIP4
Uncharacterized protein JIP4

1

1

Small-scale

0.439

High

453345

CARA
Carbamoyl phosphate synthase arginine-specific small chain

1

2

High-throughput

0.437

High

528630

CP51
Lanosterol 14-alpha demethylase CYP51

1

2

High-throughput

0.437

High

605343

CAP
Adenylyl cyclase-associated protein

1

1

High-throughput

0.437

High

610198

PDI
Protein disulfide-isomerase

1

4

High-throughput

0.437

High

754323

DCA13
Protein SOF1

1

3

High-throughput

0.437

High

798162

ARPC1
Actin-related protein 2/3 complex subunit 1

1

4

High-throughput

0.437

High

1044181

DUF1
DUB-associated factor 1

1

3

High-throughput

0.437

High

678341

RSC6
Chromatin structure-remodeling complex protein RSC6

1

0

High-throughput

0.426

High

745610

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.426

High

916597

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.426

High

917401

ITC1
Imitation switch two complex protein 1

1

0

High-throughput

0.426

High

1036946

TBF1
Protein TBF1

1

0

High-throughput

0.426

High

1040993

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.426

High

1043968

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

0

High-throughput

0.426

High

1044154

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.426

High

1044158

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.426

High

849845

BUD27
Bud site selection protein 27

1

0

Small-scale

0.288

High

550690

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.251

Low

753264

MFT1
THO complex subunit MFT1

1

0

Small-scale

0.251

Low

817220

FIR1
Factor interacting with REF2

1

0

Small-scale

0.251

Low

820506

PIG2
GSY2-interacting protein PIG2

1

0

Small-scale

0.251

Low

1043563

ESC1
Silent chromatin protein ESC1

1

0

Small-scale

0.251

Low

386845

TBB
Tubulin beta chain

1

0

High-throughput

0.249

Low

547071

PPB
Repressible alkaline phosphatase

1

0

High-throughput

0.249

Low

558853

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

636343

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.249

Low

671476

BUD5
Bud site selection protein 5

1

0

High-throughput

0.249

Low

673604

YC21A
Transposon Ty2-C Gag polyprotein

1

0

High-throughput

0.249

Low

746307

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.249

Low

746460

SSO1
Protein SSO1

1

0

High-throughput

0.249

Low

793369

PP2C4
Protein phosphatase 2C homolog 4

1

0

High-throughput

0.249

Low

794932

YBI6
Uncharacterized protein YBL086C

1

0

High-throughput

0.249

Low

794947

YBI1
Uncharacterized protein YBL081W

1

0

High-throughput

0.249

Low

795806

SHE1
Mitotic spindle-associated protein SHE1

1

0

High-throughput

0.249

Low

796674

IST2
Increased sodium tolerance protein 2

1

0

High-throughput

0.249

Low

797487

TOS1
Probable circularly permuted 1,3-beta-glucanase TOS1

1

0

High-throughput

0.249

Low

816767

IRC22
Increased recombination centers protein 22

1

0

High-throughput

0.249

Low

818193

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.249

Low

835952

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.249

Low

850987

MHP1
MAP-homologous protein 1

1

0

High-throughput

0.249

Low

863389

IMP2
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

893097

YG51
Uncharacterized protein YGR237C

1

0

High-throughput

0.249

Low

893415

PSP2
Protein PSP2

1

0

High-throughput

0.249

Low

893432

ZDS1
Protein ZDS1

1

0

High-throughput

0.249

Low

918146

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

0

High-throughput

0.249

Low

924543

PGA2
Processing of GAS1 and ALP protein 2

1

0

High-throughput

0.249

Low

1044143

ERV41
ER-derived vesicles protein ERV41

1

0

High-throughput

0.249

Low

1044148

MSC3
Meiotic sister-chromatid recombination protein 3

1

0

High-throughput

0.249

Low

1044156

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low

1044157

AIM6
Altered inheritance of mitochondria protein 6

1

0

High-throughput

0.249

Low

1044159

NBA1
Protein NBA1

1

0

High-throughput

0.249

Low

1044165

RSA1
Ribosome assembly 1 protein

1

0

High-throughput

0.249

Low

1044169

PER33
Pore and endoplasmic reticulum protein of 33 kDa

1

0

High-throughput

0.249

Low

1044173

HSP42
Heat shock protein 42

1

0

High-throughput

0.249

Low

864322

NET1
Nucleolar protein NET1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025