Protein: TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase (EC 4.1.3.44) (tRNA wybutosine-synthesizing protein 1)

Gene: TYW1
Organism: Saccharomyces cerevisiae S288C
Interactions: 41
UniProt ID: Q08960

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0010181 - FMN binding
GO:0031591 - wybutosine biosynthetic process
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

637298

PWP1
Periodic tryptophan protein 1

2

1

High-throughput

0.802

High

1065563

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

6

High-throughput

0.618

High

1046125

RRB1
Ribosome assembly protein RRB1

1

1

High-throughput

0.595

High

800924

NCB5R
NADH-cytochrome b5 reductase 1

1

9

High-throughput

0.553

High

527925

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.552

High

393478

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.541

High

546612

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.536

High

820032

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.536

High

801945

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.501

High

1056570

CSR1
Phosphatidylinositol transfer protein CSR1

1

0

High-throughput

0.493

High

657135

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

Small-scale

0.479

High

822356

ELO3
Fatty acid elongase 3

1

1

High-throughput

0.479

High

1044194

GLRX3
Monothiol glutaredoxin-3

1

3

High-throughput

0.479

High

1050090

RTN1
Reticulon-like protein 1

1

5

High-throughput

0.479

High

1065562

RIO1
Serine/threonine-protein kinase RIO1

1

0

Small-scale

0.460

High

558891

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

668304

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

726123

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

0

High-throughput

0.458

High

735870

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

Small-scale

0.458

High

809177

GAA1
GPI transamidase component GAA1

1

0

High-throughput

0.458

High

924152

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

0

High-throughput

0.458

High

1043423

LIP1
Ceramide synthase subunit LIP1

1

0

High-throughput

0.458

High

1064274

SGO1
Shugoshin

1

0

High-throughput

0.458

High

510886

HSP77
Import motor subunit, mitochondrial

1

7

High-throughput

0.445

High

525437

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

671732

SCJ1
DnaJ-related protein SCJ1

1

5

High-throughput

0.445

High

676439

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

742598

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.445

High

708442

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

795254

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

919033

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

1065561

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.437

High

394980

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

671212

SIS1
Protein SIS1

1

6

High-throughput

0.407

High

1056444

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

3

High-throughput

0.407

High

916611

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.279

Low

917874

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.279

Low

794835

KMO
Kynurenine 3-monooxygenase

1

0

High-throughput

0.249

Low

826285

SNL1
HSP70 co-chaperone SNL1

1

0

High-throughput

0.249

Low

925214

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

High-throughput

0.249

Low

807282

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025