Protein: UBP1
Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1)

Gene: UBP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 100
UniProt ID: P25037

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

436326

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

2

2

Small-scale

0.778

High

509873

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

2

2

Small-scale

0.778

High

523137

HSP71
Heat shock protein SSA1

4

2

High-throughput

0.666

High

509414

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

2

High-throughput

0.647

High

668296

ERB1
Ribosome biogenesis protein ERB1

1

0

High-throughput

0.631

High

525983

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.552

High

543899

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

668253

HSP7F
Heat shock protein homolog SSE1

2

3

High-throughput

0.552

High

578896

HSC82
ATP-dependent molecular chaperone HSC82

2

0

High-throughput

0.547

High

394262

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.546

High

668256

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

High-throughput

0.546

High

668274

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.493

High

668297

HRQ1
ATP-dependent helicase HRQ1

1

0

High-throughput

0.493

High

668309

RLM1
Transcription factor RLM1

1

0

High-throughput

0.493

High

668271

SECU
Securin

1

0

Small-scale

0.480

High

668277

CTK2
CTD kinase subunit beta

1

1

High-throughput

0.479

High

668286

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

557668

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.460

High

623774

MYO2
Myosin-2

1

0

Small-scale

0.460

High

647700

RFA1
Replication factor A protein 1

1

0

Small-scale

0.460

High

470200

NUC1
Mitochondrial nuclease

1

0

High-throughput

0.458

High

488919

SWI6
Regulatory protein SWI6

1

0

High-throughput

0.458

High

586428

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

654758

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.458

High

668243

BPH1
Beige protein homolog 1

1

0

High-throughput

0.458

High

668244

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.458

High

668247

PYRD
Dihydroorotate dehydrogenase

1

0

High-throughput

0.458

High

668248

MGLL
Monoglyceride lipase

1

0

High-throughput

0.458

High

668249

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

668250

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

668251

RIF1
Telomere length regulator protein RIF1

1

0

High-throughput

0.458

High

668254

DRI1
Putative RNA-binding protein involved in heterochromatin assembly

1

0

High-throughput

0.458

High

668255

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.458

High

668257

YKJ1
CRAL-TRIO domain-containing protein YKL091C

1

0

High-throughput

0.458

High

668258

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.458

High

668260

TBS1
Uncharacterized transcriptional regulatory protein TBS1

1

0

High-throughput

0.458

High

668264

APD1
Actin patches distal protein 1

1

0

High-throughput

0.458

High

668266

KPR3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.458

High

668269

PHM8
Phosphate metabolism protein 8

1

0

High-throughput

0.458

High

668270

IES2
Ino eighty subunit 2

1

0

High-throughput

0.458

High

668272

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.458

High

668276

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

0

High-throughput

0.458

High

668278

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

668279

BUL1
Ubiquitin ligase-binding protein BUL1

1

0

High-throughput

0.458

High

668281

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

668284

BUD17
Putative pyridoxal kinase BUD17

1

0

High-throughput

0.458

High

668285

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.458

High

668287

RAGAB
GTP-binding protein GTR1

1

0

High-throughput

0.458

High

668288

CTF4
DNA polymerase alpha-binding protein

1

0

High-throughput

0.458

High

668289

MTD1
Methylenetetrahydrofolate dehydrogenase [NAD(+)]

1

0

High-throughput

0.458

High

668291

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

0

High-throughput

0.458

High

668293

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.458

High

668295

AGE1
ADP-ribosylation factor GTPase-activating protein effector protein 1

1

0

High-throughput

0.458

High

668301

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

668302

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

0

Small-scale

0.458

High

668304

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

1

0

High-throughput

0.458

High

668305

SAM4
Homocysteine S-methyltransferase 2

1

0

High-throughput

0.458

High

668306

TSR3
18S rRNA aminocarboxypropyltransferase

1

0

High-throughput

0.458

High

668307

GET4
Golgi to ER traffic protein 4

1

0

High-throughput

0.458

High

366940

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.445

High

481493

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.445

High

592031

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

668242

SIS1
Protein SIS1

1

1

High-throughput

0.445

High

668245

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

668290

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.438

High

358121

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.426

High

359153

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

0

High-throughput

0.426

High

364939

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

386578

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

450526

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.426

High

453435

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

486046

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

618549

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.426

High

649913

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.426

High

668246

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

668263

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.426

High

668275

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

603411

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.407

High

664574

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

1

0

High-throughput

0.269

Low

603587

KRE1
Protein KRE1

1

0

High-throughput

0.249

Low

646634

VPS15
Serine/threonine-protein kinase VPS15

1

0

High-throughput

0.249

Low

668252

ATP11
Protein ATP11, mitochondrial

1

0

High-throughput

0.249

Low

668259

SEG2
Eisosome protein SEG2

1

0

High-throughput

0.249

Low

668261

PANB
3-methyl-2-oxobutanoate hydroxymethyltransferase

1

0

High-throughput

0.249

Low

668262

YBI1
Uncharacterized protein YBL081W

1

0

High-throughput

0.249

Low

668265

RGD1
RHO GTPase-activating protein RGD1

1

0

High-throughput

0.249

Low

668267

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

668268

FIR1
Factor interacting with REF2

1

0

High-throughput

0.249

Low

668273

PUP1
PUP1 protein homolog

1

0

High-throughput

0.249

Low

668280

RL4P
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.249

Low

668282

YIP5
Protein YIP5

1

0

High-throughput

0.249

Low

668283

YGL7
Uncharacterized protein YGL117W

1

0

High-throughput

0.249

Low

668292

YD090
Uncharacterized membrane protein YDR090C

1

0

High-throughput

0.249

Low

668294

YMD7
Uncharacterized protein YML037C

1

0

High-throughput

0.249

Low

668298

VTA1
Vacuolar protein sorting-associated protein VTA1

1

0

High-throughput

0.249

Low

668299

YPQ2
Vacuolar arginine/histidine antiporter YPQ2

1

0

High-throughput

0.249

Low

668300

YD073
UPF0592 protein YDL073W

1

0

High-throughput

0.249

Low

668303

YO036
Uncharacterized protein YOL036W

1

0

High-throughput

0.249

Low

668308

RFM1
Repression factor of MSEs protein 1

1

0

High-throughput

0.249

Low

575389

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025