Protein: SPT8
SAGA complex subunit SPT8 (Suppressor of Ty protein 8) (Transcription factor SPT8)

Gene: SPT8
Organism: Saccharomyces cerevisiae S288C
Interactions: 210
UniProt ID: P38915

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000124 - SAGA complex
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006325 - chromatin organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

762956

SPT7
SAGA complex subunit SPT7

19

2

Small-scale

0.764

High

807260

ADA2
SAGA complex subunit ADA2

14

1

Small-scale

0.761

High

807285

HFI1
SAGA complex subunit HFI1

9

1

Small-scale

0.753

High

805179

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

8

1

Small-scale

0.750

High

807246

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

13

0

Small-scale

0.728

High

807245

SPT20
SAGA complex subunit SPT20

12

0

Small-scale

0.727

High

807263

GCN5
Histone acetyltransferase GCN5

11

0

Small-scale

0.725

High

793918

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

11

0

Small-scale

0.723

High

807243

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

11

0

Small-scale

0.723

High

738152

NGG1
SAGA complex subunit NGG1

8

0

Small-scale

0.720

High

807266

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

8

0

Small-scale

0.717

High

449457

SPT3
SAGA complex subunit SPT3

7

0

Small-scale

0.714

High

807262

SGF11
SAGA complex subunit SGF11

7

0

Small-scale

0.712

High

807284

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

7

0

Small-scale

0.709

High

676639

SGF29
SAGA complex subunit SGF29

6

0

Small-scale

0.702

High

807249

SGF73
SAGA complex subunit SGF73

6

0

Small-scale

0.702

High

807295

SUS1
SAGA complex subunit SUS1

6

0

Small-scale

0.702

High

807272

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

6

0

Small-scale

0.701

High

561475

TBP
TATA-box-binding protein

5

0

Small-scale

0.688

High

807267

RUVB1
RuvB-like protein 1

2

1

High-throughput

0.611

High

454573

TFS2
Transcription elongation factor S-II

2

0

Small-scale

0.593

High

452736

ADR1
Regulatory protein ADR1

2

0

High-throughput

0.576

High

638008

PRP5
Pre-mRNA-processing ATP-dependent RNA helicase PRP5

1

1

Small-scale

0.561

High

807238

TAF1
Transcription initiation factor TFIID subunit 1

2

0

Small-scale

0.560

High

734423

BTAF1
TATA-binding protein-associated factor MOT1

2

0

Small-scale

0.559

High

359010

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.536

High

401997

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.536

High

750841

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.536

High

803537

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.536

High

807228

PRS4
26S proteasome regulatory subunit 4 homolog

1

2

High-throughput

0.536

High

807242

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

High-throughput

0.536

High

807286

YG11B
Transposon Ty1-GR1 Gag-Pol polyprotein

1

1

High-throughput

0.536

High

807292

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.536

High

656313

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

2

1

Small-scale

0.534

High

470526

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

534060

HSF
Heat shock transcription factor

1

0

High-throughput

0.513

High

750657

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.513

High

807214

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.513

High

673700

KCC4
Probable serine/threonine-protein kinase KCC4

1

1

High-throughput

0.501

High

801825

KSP1
Serine/threonine-protein kinase KSP1

1

1

High-throughput

0.501

High

359474

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

High-throughput

0.489

High

553990

TCPA
T-complex protein 1 subunit alpha

1

2

High-throughput

0.489

High

603466

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.489

High

807217

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.489

High

807218

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.489

High

807229

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.489

High

807235

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.489

High

807239

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.489

High

748842

SWE1
Mitosis inhibitor protein kinase SWE1

1

0

High-throughput

0.480

High

807216

AURK
Aurora kinase

1

0

High-throughput

0.480

High

807244

TAF4
Transcription initiation factor TFIID subunit 4

1

0

Small-scale

0.480

High

807291

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.479

High

624911

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

Small-scale

0.460

High

448720

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.458

High

707077

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

737855

HOG1
Mitogen-activated protein kinase HOG1

1

0

Small-scale

0.458

High

745736

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

747848

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

800701

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

807231

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

807268

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

807274

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

807287

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

807294

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

575591

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

1

Small-scale

0.457

High

445341

CDC31
Cell division control protein 31

1

1

High-throughput

0.445

High

481620

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.445

High

504600

YL12B
Transposon Ty1-LR2 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

523930

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

526677

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

534264

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.445

High

544850

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

590622

HSP26
Heat shock protein 26

1

1

High-throughput

0.445

High

740160

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.445

High

743025

SWI3
SWI/SNF complex subunit SWI3

1

1

High-throughput

0.445

High

754153

MSN2
Zinc finger protein MSN2

1

1

High-throughput

0.445

High

754209

MSN4
Zinc finger protein MSN4

1

1

High-throughput

0.445

High

804156

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

807259

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

High-throughput

0.445

High

807283

NEW1
[NU+] prion formation protein 1

1

1

High-throughput

0.445

High

807280

SDO1
Ribosome maturation protein SDO1

1

0

High-throughput

0.438

High

779124

DHR2
Probable ATP-dependent RNA helicase DHR2

1

1

High-throughput

0.437

High

368238

TRP
Tryptophan synthase

1

0

High-throughput

0.426

High

436409

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.426

High

448170

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.426

High

459089

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.426

High

564658

STE12
Protein STE12

1

0

High-throughput

0.426

High

584913

TRM1
tRNA

1

0

High-throughput

0.426

High

597134

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

614822

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

0

High-throughput

0.426

High

626505

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.426

High

645612

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.426

High

649223

SAN1
Protein SAN1

1

0

High-throughput

0.426

High

649961

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.426

High

655621

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.426

High

666456

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.426

High

670265

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.426

High

671526

SWI4
Regulatory protein SWI4

1

0

High-throughput

0.426

High

677679

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.426

High

678836

AHC2
ADA histone acetyltransferase complex component 2

1

0

High-throughput

0.426

High

679668

CDC48
Cell division control protein 48

1

0

High-throughput

0.426

High

692567

NSR1
Nuclear localization sequence-binding protein

1

0

High-throughput

0.426

High

694202

BUD14
Bud site selection protein 14

1

0

High-throughput

0.426

High

694545

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

725916

PSK1
Serine/threonine-protein kinase PSK1

1

0

High-throughput

0.426

High

739632

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.426

High

739863

RPD3
Histone deacetylase RPD3

1

0

High-throughput

0.426

High

760254

BMH2
Protein BMH2

1

0

High-throughput

0.426

High

779054

EF1G2
Elongation factor 1-gamma 2

1

0

High-throughput

0.426

High

781712

SA190
SIT4-associating protein SAP190

1

0

High-throughput

0.426

High

792042

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.426

High

807222

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.426

High

807225

SNU13
13 kDa ribonucleoprotein-associated protein

1

0

High-throughput

0.426

High

807226

MIT1
Transcriptional regulator MIT1

1

0

High-throughput

0.426

High

807247

MCM6
DNA replication licensing factor MCM6

1

0

High-throughput

0.426

High

807248

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.426

High

807253

H3
Histone H3

1

0

High-throughput

0.426

High

807255

REG1
Resistance to glucose repression protein 1

1

0

High-throughput

0.426

High

807257

NOP3
Serine/arginine

1

0

High-throughput

0.426

High

807261

NOG1
Nucleolar GTP-binding protein 1

1

0

High-throughput

0.426

High

807269

PPN1
Endopolyphosphatase

1

0

High-throughput

0.426

High

807271

ERB1
Ribosome biogenesis protein ERB1

1

0

High-throughput

0.426

High

807275

ELP1
Elongator complex protein 1

1

0

High-throughput

0.426

High

807281

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.426

High

807288

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.426

High

427568

RLA1
Large ribosomal subunit protein P1A

1

1

High-throughput

0.407

High

518291

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.407

High

528818

RLA3
Large ribosomal subunit protein P1B

1

1

High-throughput

0.407

High

597458

EF3A
Elongation factor 3A

1

1

High-throughput

0.407

High

616421

SEC18
Vesicular-fusion protein SEC18

1

1

High-throughput

0.407

High

673502

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

1

High-throughput

0.407

High

705765

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

1

High-throughput

0.407

High

738587

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.407

High

807219

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.407

High

807230

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.407

High

807233

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.407

High

807234

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

807251

COPA
Coatomer subunit alpha

1

1

High-throughput

0.407

High

807256

ACAC
Acetyl-CoA carboxylase

1

1

High-throughput

0.407

High

807289

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

386703

TBB
Tubulin beta chain

1

0

High-throughput

0.279

Low

427696

RLA2
Large ribosomal subunit protein P2A

1

0

High-throughput

0.279

Low

439128

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.279

Low

450587

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.279

Low

572576

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.279

Low

575450

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.279

Low

579374

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.279

Low

599019

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.279

Low

639448

DIT1
Spore wall maturation protein DIT1

1

0

High-throughput

0.279

Low

743681

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.279

Low

746730

KPR1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.279

Low

763435

MDJ1
DnaJ homolog 1, mitochondrial

1

0

High-throughput

0.279

Low

807220

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.279

Low

807221

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.279

Low

807265

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.279

Low

807279

PUF3
mRNA-binding protein PUF3

1

0

High-throughput

0.279

Low

807290

SFI1
Protein SFI1

1

0

High-throughput

0.279

Low

807270

PDR15
ATP-dependent permease PDR15

1

0

High-throughput

0.269

Low

807236

TOS3
Serine/threonine-protein kinase TOS3

1

0

High-throughput

0.261

Low

408574

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

Small-scale

0.249

Low

475167

CISY2
Citrate synthase, peroxisomal

1

0

Small-scale

0.249

Low

807215

ASPG1
L-asparaginase 1

1

0

High-throughput

0.249

Low

807240

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.249

Low

807264

YMO7
Uncharacterized protein YMR007W

1

0

High-throughput

0.249

Low

807278

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

358210

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.232

Low

427275

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

430847

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

High-throughput

0.232

Low

449123

CALM
Calmodulin

1

0

High-throughput

0.232

Low

453595

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

471402

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.232

Low

477559

MYO1
Myosin-1

1

0

High-throughput

0.232

Low

510481

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.232

Low

553613

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.232

Low

569785

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.232

Low

577300

NSP1
Nucleoporin NSP1

1

0

High-throughput

0.232

Low

585171

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.232

Low

592242

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

605314

CAP
Adenylyl cyclase-associated protein

1

0

High-throughput

0.232

Low

609222

CLC1
Clathrin light chain

1

0

High-throughput

0.232

Low

623854

MYO2
Myosin-2

1

0

High-throughput

0.232

Low

626732

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

644775

CLH
Clathrin heavy chain

1

0

High-throughput

0.232

Low

701700

URA7
CTP synthase 1

1

0

High-throughput

0.232

Low

734095

EF2
Elongation factor 2

1

0

High-throughput

0.232

Low

736094

ARP2
Actin-related protein 2

1

0

High-throughput

0.232

Low

737722

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

0

High-throughput

0.232

Low

738381

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.232

Low

738642

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.232

Low

760584

TSA1
Peroxiredoxin TSA1

1

0

High-throughput

0.232

Low

779406

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.232

Low

793321

SYG
Glycine--tRNA ligase 1, mitochondrial

1

0

High-throughput

0.232

Low

794704

SEA4
SEH-associated protein 4

1

0

High-throughput

0.232

Low

802544

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.232

Low

807223

BEM2
GTPase-activating protein BEM2/IPL2

1

0

High-throughput

0.232

Low

807224

DPO5
rDNA transcriptional regulator POL5

1

0

High-throughput

0.232

Low

807227

GLE2
mRNA export factor GLE2

1

0

High-throughput

0.232

Low

807232

COPB
Coatomer subunit beta

1

0

High-throughput

0.232

Low

807237

ARC1
tRNA-aminoacylation cofactor ARC1

1

0

High-throughput

0.232

Low

807241

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.232

Low

807250

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.232

Low

807252

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.232

Low

807254

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.232

Low

807258

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.232

Low

807273

NGK1
N-acetylglucosamine kinase

1

0

High-throughput

0.232

Low

807276

MRL1
Mannose 6-phosphate receptor-like protein 1

1

0

High-throughput

0.232

Low

807277

YD073
UPF0592 protein YDL073W

1

0

High-throughput

0.232

Low

807282

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

1

0

High-throughput

0.232

Low

807293

NOP58
Nucleolar protein 58

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025