Protein: SSN2
Mediator of RNA polymerase II transcription subunit 13 (Mediator complex subunit 13) (Protein SCA1) (Suppressor of RNA polymerase B SSN2)

Gene: SSN2
Organism: Saccharomyces cerevisiae S288C
Interactions: 149
UniProt ID: P38931

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000435 - positive regulation of transcription from RNA polymerase II promoter by galactose
GO:0003713 - transcription coactivator activity
GO:0016592 - mediator complex
GO:0045944 - positive regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

758000

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

7

0

Small-scale

0.715

High

757980

SSN3
Meiotic mRNA stability protein kinase SSN3

6

0

Small-scale

0.702

High

693538

MED17
Mediator of RNA polymerase II transcription subunit 17

6

0

Small-scale

0.699

High

635992

SRB8
Mediator of RNA polymerase II transcription subunit 12

5

0

Small-scale

0.684

High

758028

MED7
Mediator of RNA polymerase II transcription subunit 7

5

0

Small-scale

0.684

High

693922

MED18
Mediator of RNA polymerase II transcription subunit 18

5

0

Small-scale

0.678

High

693589

MED22
Mediator of RNA polymerase II transcription subunit 22

3

0

High-throughput

0.634

High

758001

MED21
Mediator of RNA polymerase II transcription subunit 21

3

0

Small-scale

0.628

High

758005

MED5
Mediator of RNA polymerase II transcription subunit 5

3

0

Small-scale

0.628

High

626031

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

High-throughput

0.616

High

758031

MED2
Mediator of RNA polymerase II transcription subunit 2

3

0

High-throughput

0.616

High

581364

MED14
Mediator of RNA polymerase II transcription subunit 14

2

0

High-throughput

0.585

High

686846

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.585

High

758035

MED1
Mediator of RNA polymerase II transcription subunit 1

2

0

High-throughput

0.585

High

758024

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

Small-scale

0.569

High

758037

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

Small-scale

0.569

High

751461

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

High-throughput

0.547

High

491213

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.504

High

589548

SFL1
Flocculation suppression protein

1

0

Small-scale

0.493

High

748102

MED8
Mediator of RNA polymerase II transcription subunit 8

1

1

High-throughput

0.479

High

423683

ADR1
Regulatory protein ADR1

1

0

Small-scale

0.458

High

577302

GLN3
Nitrogen regulatory protein GLN3

1

0

Small-scale

0.458

High

586306

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

High-throughput

0.458

High

649959

BUD14
Bud site selection protein 14

1

0

Small-scale

0.458

High

693435

PAH1
Phosphatidic acid phosphohydrolase 1

1

0

Small-scale

0.458

High

704151

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.458

High

710263

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.458

High

754272

MED6
Mediator of RNA polymerase II transcription subunit 6

1

0

High-throughput

0.458

High

757987

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

High-throughput

0.458

High

758041

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

701874

SWE1
Mitosis inhibitor protein kinase SWE1

1

1

High-throughput

0.457

High

758027

ATG20
Autophagy-related protein 20

1

1

Small-scale

0.439

High

425121

LEUC
3-isopropylmalate dehydratase

1

1

Small-scale

0.437

High

526142

KIN1
Serine/threonine protein kinase KIN1

1

1

Small-scale

0.437

High

547986

DAL5
Allantoate permease

1

1

Small-scale

0.437

High

548531

GCN2
eIF-2-alpha kinase GCN2

1

1

Small-scale

0.437

High

550034

CSK21
Casein kinase II subunit alpha

1

1

Small-scale

0.437

High

580823

GAP1
General amino-acid permease GAP1

1

1

Small-scale

0.437

High

584158

ACON
Aconitate hydratase, mitochondrial

1

1

Small-scale

0.437

High

584734

CSK22
Casein kinase II subunit alpha'

1

1

Small-scale

0.437

High

630722

AGP1
General amino acid permease AGP1

1

1

Small-scale

0.437

High

730509

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

1

Small-scale

0.437

High

741413

PAM1
Protein PAM1

1

1

Small-scale

0.437

High

752115

KSP1
Serine/threonine-protein kinase KSP1

1

1

Small-scale

0.437

High

757935

CSK2C
Casein kinase II subunit beta'

1

1

Small-scale

0.437

High

757982

SAP1
Protein SAP1

1

1

Small-scale

0.437

High

757994

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.437

High

758009

CA120
CCR4-NOT transcriptional complex subunit CAF120

1

1

Small-scale

0.437

High

758014

SVL3
Styryl dye vacuolar localization protein 3

1

1

Small-scale

0.437

High

758025

SKG3
Protein SKG3

1

1

Small-scale

0.437

High

758030

RTK1
Probable serine/threonine-protein kinase RTK1

1

1

Small-scale

0.437

High

493958

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

694694

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

425470

TFS2
Transcription elongation factor S-II

2

0

Small-scale

0.323

High

758008

CAF40
Protein CAF40

2

0

Small-scale

0.313

High

624292

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

2

0

Small-scale

0.304

High

680028

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

Small-scale

0.299

High

733373

CAF4
CCR4-associated factor 4

1

0

Small-scale

0.299

High

409838

NOT2
General negative regulator of transcription subunit 2

1

0

Small-scale

0.288

High

636135

NOT1
General negative regulator of transcription subunit 1

1

0

Small-scale

0.288

High

757998

SNX4
Sorting nexin-4

1

0

Small-scale

0.288

High

758034

GLE1
mRNA export factor GLE1

1

0

Small-scale

0.288

High

754944

HTD2
Hydroxyacyl-thioester dehydratase type 2, mitochondrial

1

0

High-throughput

0.269

Low

757979

POP2
Poly(A) ribonuclease POP2

1

0

Small-scale

0.265

Low

757993

CAF16
CCR4-associated factor 16

1

0

Small-scale

0.265

Low

409645

KAPC
cAMP-dependent protein kinase type 3

1

0

High-throughput

0.261

Low

419881

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.261

Low

679741

PSK1
Serine/threonine-protein kinase PSK1

1

0

Small-scale

0.251

Low

375388

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.249

Low

410796

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

Small-scale

0.249

Low

410996

PDC1
Pyruvate decarboxylase isozyme 1

1

0

Small-scale

0.249

Low

421638

FAS1
Fatty acid synthase subunit beta

1

0

Small-scale

0.249

Low

443934

CYAA
Adenylate cyclase

1

0

Small-scale

0.249

Low

520977

G6PI
Glucose-6-phosphate isomerase

1

0

Small-scale

0.249

Low

537414

ALF
Fructose-bisphosphate aldolase

1

0

Small-scale

0.249

Low

543724

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

566175

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.249

Low

579976

IRA1
Inhibitory regulator protein IRA1

1

0

Small-scale

0.249

Low

625814

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

Small-scale

0.249

Low

636622

CDC48
Cell division control protein 48

1

0

Small-scale

0.249

Low

649269

CBPS
Carboxypeptidase S

1

0

Small-scale

0.249

Low

653841

KRE2
Glycolipid 2-alpha-mannosyltransferase

1

0

Small-scale

0.249

Low

657065

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

0

Small-scale

0.249

Low

657132

UBC8
Ubiquitin-conjugating enzyme E2-24 kDa

1

0

Small-scale

0.249

Low

660072

KIP2
Kinesin-like protein KIP2

1

0

Small-scale

0.249

Low

662211

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

685524

COPG
Coatomer subunit gamma

1

0

Small-scale

0.249

Low

689424

YBT1
ATP-dependent bile acid permease

1

0

Small-scale

0.249

Low

690487

HXT3
Low-affinity glucose transporter HXT3

1

0

Small-scale

0.249

Low

690669

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

Small-scale

0.249

Low

692661

DUR1
Urea amidolyase [Includes: Urea carboxylase

1

0

Small-scale

0.249

Low

694040

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.249

Low

698079

YSC84
Protein YSC84

1

0

Small-scale

0.249

Low

698259

CDC13
Cell division control protein 13

1

0

Small-scale

0.249

Low

700139

PTR2
Peptide transporter PTR2

1

0

Small-scale

0.249

Low

701657

STE5
Protein STE5

1

0

Small-scale

0.249

Low

710883

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

Small-scale

0.249

Low

716421

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

730609

LTHAD
L-threo-3-hydroxyaspartate ammonia-lyase

1

0

Small-scale

0.249

Low

743391

AP2A
AP-2 complex subunit alpha

1

0

Small-scale

0.249

Low

746064

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

Small-scale

0.249

Low

746476

DSF2
Protein DSF2

1

0

Small-scale

0.249

Low

747205

EXO84
Exocyst complex component EXO84

1

0

Small-scale

0.249

Low

748428

YB75
Uncharacterized protein YBR225W

1

0

Small-scale

0.249

Low

751022

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.249

Low

755486

SBE22
Protein SBE22

1

0

Small-scale

0.249

Low

757978

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

0

Small-scale

0.249

Low

757981

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.249

Low

757983

BEM2
GTPase-activating protein BEM2/IPL2

1

0

Small-scale

0.249

Low

757984

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

0

Small-scale

0.249

Low

757985

YAT2
Carnitine O-acetyltransferase YAT2

1

0

Small-scale

0.249

Low

757986

DOT6
Transcriptional regulatory protein DOT6

1

0

Small-scale

0.249

Low

757988

MET18
DNA repair/transcription protein MET18/MMS19

1

0

Small-scale

0.249

Low

757989

PRP17
Pre-mRNA-processing factor 17

1

0

Small-scale

0.249

Low

757990

FKS2
1,3-beta-glucan synthase component GSC2

1

0

Small-scale

0.249

Low

757991

VATH
V-type proton ATPase subunit H

1

0

Small-scale

0.249

Low

757992

BNI1
Protein BNI1

1

0

Small-scale

0.249

Low

757995

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

Small-scale

0.249

Low

757996

FYV8
Protein FYV8

1

0

Small-scale

0.249

Low

757997

BNA3
Probable kynurenine--oxoglutarate transaminase BNA3

1

0

Small-scale

0.249

Low

757999

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

Small-scale

0.249

Low

758002

YG51
Uncharacterized protein YGR237C

1

0

Small-scale

0.249

Low

758003

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.249

Low

758004

ACS2
Acetyl-coenzyme A synthetase 2

1

0

Small-scale

0.249

Low

758006

PALF
pH-response regulator protein palF/RIM8

1

0

Small-scale

0.249

Low

758007

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

0

Small-scale

0.249

Low

758010

VPS75
Vacuolar protein sorting-associated protein 75

1

0

Small-scale

0.249

Low

758011

SQS1
Protein SQS1

1

0

Small-scale

0.249

Low

758012

SFB2
SED5-binding protein 2

1

0

Small-scale

0.249

Low

758013

ORC1
Origin recognition complex subunit 1

1

0

Small-scale

0.249

Low

758015

YD239
Uncharacterized protein YDR239C

1

0

Small-scale

0.249

Low

758016

WDR59
Maintenance of telomere capping protein 5

1

0

Small-scale

0.249

Low

758017

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

758018

SND1
SRP-independent targeting protein 1

1

0

Small-scale

0.249

Low

758019

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.249

Low

758020

ERB1
Ribosome biogenesis protein ERB1

1

0

Small-scale

0.249

Low

758021

RQC1
Ribosome quality control complex subunit 1

1

0

Small-scale

0.249

Low

758022

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.249

Low

758023

MSC3
Meiotic sister-chromatid recombination protein 3

1

0

Small-scale

0.249

Low

758026

ATG17
Autophagy-related protein 17

1

0

Small-scale

0.249

Low

758029

NUR1
Nuclear rim protein 1

1

0

Small-scale

0.249

Low

758033

YO093
Uncharacterized protein YOR093C

1

0

Small-scale

0.249

Low

758036

HSP42
Heat shock protein 42

1

0

Small-scale

0.249

Low

758038

RLF2
Chromatin assembly factor 1 subunit p90

1

0

Small-scale

0.249

Low

758039

AVL9
Late secretory pathway protein AVL9

1

0

Small-scale

0.249

Low

758040

RQC2
Ribosome quality control complex subunit 2

1

0

Small-scale

0.249

Low

511300

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.232

Low

705173

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

758032

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024