Protein: SIR1
Regulatory protein SIR1 (Heterochromatin protein SIR1) (Silent information regulator 1)

Gene: SIR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 21
UniProt ID: P21691

Gene Ontology (top 5):
GO:0000775 - chromosome, centromeric region
GO:0005677 - chromatin silencing complex
GO:0030466 - silent mating-type cassette heterochromatin formation
GO:0031507 - heterochromatin formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

639868

ORC1
Origin recognition complex subunit 1

7

1

Small-scale

0.972

High

444828

SIR3
Regulatory protein SIR3

3

1

Small-scale

0.860

High

550623

SIR4
Regulatory protein SIR4

6

0

Small-scale

0.696

High

639871

CAF1A
Chromatin assembly factor 1 subunit A

1

0

Small-scale

0.561

High

639865

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.504

High

444738

SIR2
NAD-dependent histone deacetylase SIR2

1

0

Small-scale

0.493

High

543814

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.489

High

639860

ORC2
Origin recognition complex subunit 2

1

0

Small-scale

0.458

High

639869

ORC3
Origin recognition complex subunit 3

1

0

Small-scale

0.458

High

523056

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.407

High

525921

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

639859

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

548259

FUS1
Nuclear fusion protein FUS1

2

0

High-throughput

0.323

High

639872

YC021
Putative uncharacterized protein YCL021W-A

1

0

High-throughput

0.282

High

639861

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.279

Low

639864

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.269

Low

639867

SHY1
Cytochrome oxidase assembly protein SHY1

1

0

Small-scale

0.249

Low

639870

CDC14
Tyrosine-protein phosphatase CDC14

1

0

Small-scale

0.249

Low

639862

CAJ1
Protein CAJ1

1

0

High-throughput

0.232

Low

639863

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.232

Low

639866

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025