Protein: SIR4
Regulatory protein SIR4 (Silent information regulator 4)

Gene: SIR4
Organism: Saccharomyces cerevisiae S288C
Interactions: 120
UniProt ID: P11978

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0003690 - double-stranded DNA binding
GO:0005677 - chromatin silencing complex
GO:0006303 - double-strand break repair via nonhomologous end joining
GO:0030466 - silent mating-type cassette heterochromatin formation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

444732

SIR2
NAD-dependent histone deacetylase SIR2

30

1

Small-scale

0.993

High

444821

SIR3
Regulatory protein SIR3

22

0

Small-scale

0.734

High

550693

KU80
ATP-dependent DNA helicase II subunit 2

5

1

Small-scale

0.722

High

550019

RAP1
DNA-binding protein RAP1

7

0

Small-scale

0.722

High

550679

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

5

1

Small-scale

0.717

High

550688

ESC1
Silent chromatin protein ESC1

6

0

Small-scale

0.703

High

550611

SIR4
Regulatory protein SIR4

6

0

Small-scale

0.699

High

550623

SIR1
Regulatory protein SIR1

6

0

Small-scale

0.696

High

550639

KU70
ATP-dependent DNA helicase II subunit 1

4

1

Small-scale

0.691

High

550678

HST1
NAD-dependent protein deacetylase HST1

1

1

Small-scale

0.618

High

550650

NU170
Nucleoporin NUP170

2

1

Small-scale

0.611

High

550660

NU157
Nucleoporin NUP157

3

1

Small-scale

0.596

High

550669

MPS3
Spindle pole body assembly component MPS3

2

0

Small-scale

0.593

High

550661

RT106
Histone chaperone RTT106

1

0

Small-scale

0.554

High

550681

ZDS2
Protein ZDS2

2

1

Small-scale

0.552

High

550683

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

2

1

Small-scale

0.543

High

364281

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.537

High

522870

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.521

High

550640

ORC2
Origin recognition complex subunit 2

1

0

Small-scale

0.518

High

550638

CDC13
Cell division control protein 13

1

0

Small-scale

0.504

High

510128

HSP77
Import motor subunit, mitochondrial

2

1

High-throughput

0.504

High

550687

VPS71
Vacuolar protein sorting-associated protein 71

1

0

High-throughput

0.493

High

550672

ZDS1
Protein ZDS1

1

1

Small-scale

0.481

High

550701

DIA2
Protein DIA2

1

0

Small-scale

0.480

High

550649

ATM
Serine/threonine-protein kinase TEL1

1

0

Small-scale

0.460

High

550667

SUM1
Suppressor of mar1-1 protein

1

0

Small-scale

0.460

High

419338

H2A1
Histone H2A.1

1

0

Small-scale

0.458

High

550621

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

550632

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.458

High

550648

NU133
Nucleoporin NUP133

1

0

Small-scale

0.458

High

550671

NU145
Nucleoporin NUP145

1

0

Small-scale

0.458

High

550674

NUP84
Nucleoporin NUP84

1

0

Small-scale

0.458

High

550694

NSE3
Non-structural maintenance of chromosome element 3

1

0

Small-scale

0.458

High

550705

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

Small-scale

0.458

High

550706

SMC6
Structural maintenance of chromosomes protein 6

1

0

Small-scale

0.458

High

452795

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.457

High

485993

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.457

High

486391

TBA3
Tubulin alpha-3 chain

1

1

High-throughput

0.457

High

550617

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.457

High

550630

BMH1
Protein BMH1

1

1

High-throughput

0.457

High

550645

BMH2
Protein BMH2

1

1

High-throughput

0.457

High

550700

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.457

High

550704

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

1

High-throughput

0.457

High

408385

GAL4
Regulatory protein GAL4

1

1

Small-scale

0.439

High

550657

CAJ1
Protein CAJ1

1

1

Small-scale

0.437

High

550680

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.437

High

392112

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.407

High

481448

HSP73
Heat shock protein SSA3

1

1

High-throughput

0.407

High

543614

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

550615

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.407

High

550627

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.407

High

550635

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.407

High

550636

HSP79
Heat shock protein homolog SSE2

1

3

High-throughput

0.407

High

550659

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

550662

6P21
6-phosphofructo-2-kinase 1

1

1

High-throughput

0.407

High

381825

H4
Histone H4

5

0

Small-scale

0.375

High

550682

H3
Histone H3

3

0

Small-scale

0.351

High

550651

SIF2
SIR4-interacting protein SIF2

3

0

Small-scale

0.344

High

550625

SAN1
Protein SAN1

2

0

Small-scale

0.323

High

550619

CBF1
Centromere-binding protein 1

1

0

Small-scale

0.292

High

550641

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

Small-scale

0.292

High

550686

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

Small-scale

0.292

High

455467

PMM
Phosphomannomutase

1

0

High-throughput

0.279

Low

550666

BLM10
Proteasome activator BLM10

1

0

High-throughput

0.279

Low

550685

IMA1
Importin subunit alpha

1

0

High-throughput

0.279

Low

550634

RPN2
26S proteasome regulatory subunit RPN2

1

0

High-throughput

0.269

Low

550695

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

0

High-throughput

0.269

Low

550696

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.269

Low

550646

EBP2
rRNA-processing protein EBP2

1

0

Small-scale

0.265

Low

550702

ULS1
ATP-dependent helicase ULS1

1

0

Small-scale

0.265

Low

550703

RRS1
Regulator of ribosome biosynthesis

1

0

Small-scale

0.265

Low

550614

DPOLA
DNA polymerase alpha catalytic subunit A

1

0

Small-scale

0.261

Low

368567

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

386538

TBB
Tubulin beta chain

1

0

High-throughput

0.261

Low

416353

HXKA
Hexokinase-1

1

0

High-throughput

0.261

Low

425098

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.261

Low

550612

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.261

Low

550613

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

550616

HSP26
Heat shock protein 26

1

0

High-throughput

0.261

Low

550618

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.261

Low

550622

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.261

Low

550620

KAR3
Kinesin-like protein KAR3

1

0

High-throughput

0.251

Low

550637

CHD1
Chromo domain-containing protein 1

1

0

Small-scale

0.251

Low

550642

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.251

Low

550643

NUF2
Kinetochore protein NUF2

1

0

High-throughput

0.251

Low

550647

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.251

Low

550652

CENPU
Inner kinetochore subunit AME1

1

0

High-throughput

0.251

Low

550653

ETP1
RING finger protein ETP1

1

0

High-throughput

0.251

Low

550654

RT107
Regulator of Ty1 transposition protein 107

1

0

Small-scale

0.251

Low

550655

KEL1
Kelch repeat-containing protein 1

1

0

High-throughput

0.251

Low

550665

BUD27
Bud site selection protein 27

1

0

Small-scale

0.251

Low

550676

NMA2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

1

0

Small-scale

0.251

Low

550677

NNF2
Protein NNF2

1

0

High-throughput

0.251

Low

550684

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.251

Low

550690

GIS1
Transcriptional activator/repressor GIS1

1

0

Small-scale

0.251

Low

550698

ARR1
Arsenical-resistance protein ARR1

1

0

High-throughput

0.251

Low

148854

CET1
mRNA-capping enzyme subunit beta

1

0

Small-scale

0.249

Low

380935

H2B1
Histone H2B.1

1

0

Small-scale

0.249

Low

401847

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.249

Low

550624

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.249

Low

550626

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.249

Low

550628

CSM1
Monopolin complex subunit CSM1

1

0

Small-scale

0.249

Low

550629

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

550631

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

550633

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

550644

NIC96
Nucleoporin NIC96

1

0

Small-scale

0.249

Low

550656

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.249

Low

550658

PO152
Nucleoporin POM152

1

0

Small-scale

0.249

Low

550663

YRB2
Ran-specific GTPase-activating protein 2

1

0

Small-scale

0.249

Low

550664

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

550668

NU192
Nucleoporin NUP192

1

0

Small-scale

0.249

Low

550673

NU188
Nucleoporin NUP188

1

0

Small-scale

0.249

Low

550675

ACS2
Acetyl-coenzyme A synthetase 2

1

0

Small-scale

0.249

Low

550689

SRC1
Inner nuclear membrane protein SRC1

1

0

Small-scale

0.249

Low

550691

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

550692

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.249

Low

550697

LSM6
LSM complex subunit LSM6

1

0

Small-scale

0.249

Low

550699

TSR1
Ribosome biogenesis protein TSR1

1

0

Small-scale

0.249

Low

550670

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025