Protein: ORC3
Origin recognition complex subunit 3 (Origin recognition complex 62 kDa subunit)

Gene: ORC3
Organism: Saccharomyces cerevisiae S288C
Interactions: 52
UniProt ID: P54790

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005656 - nuclear pre-replicative complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

932204

ORC1
Origin recognition complex subunit 1

14

2

Small-scale

0.980

High

932313

ORC4
Origin recognition complex subunit 4

8

2

Small-scale

0.964

High

745664

ORC2
Origin recognition complex subunit 2

14

0

Small-scale

0.933

High

898170

ORC5
Origin recognition complex subunit 5

8

0

Small-scale

0.916

High

479275

CDC6
Cell division control protein 6

4

2

Small-scale

0.885

High

805521

ORC6
Origin recognition complex subunit 6

9

0

Small-scale

0.720

High

932312

ORC3
Origin recognition complex subunit 3

2

0

Small-scale

0.705

High

932320

HAT1
Histone acetyltransferase type B catalytic subunit

3

0

Small-scale

0.622

High

793889

PCH2
Pachytene checkpoint protein 2

1

0

Small-scale

0.614

High

713019

MCM2
DNA replication licensing factor MCM2

2

0

Small-scale

0.602

High

734274

DBF4
DDK kinase regulatory subunit DBF4

2

0

Small-scale

0.593

High

718955

CGS5
S-phase entry cyclin-5

2

0

Small-scale

0.585

High

932321

CAF1A
Chromatin assembly factor 1 subunit A

2

0

Small-scale

0.583

High

816145

HAT2
Histone acetyltransferase type B subunit 2

2

0

Small-scale

0.576

High

727238

HS104
Heat shock protein 104

1

1

High-throughput

0.575

High

381206

H2B1
Histone H2B.1

2

1

High-throughput

0.571

High

932314

H3
Histone H3

2

0

Small-scale

0.547

High

649552

CHL1
ATP-dependent DNA helicase CHL1

1

0

Small-scale

0.529

High

918948

PESC
Pescadillo homolog

1

0

Small-scale

0.527

High

662095

MPIP
M-phase inducer phosphatase

1

0

Small-scale

0.518

High

782290

MSA2
Putative transcriptional activator MSA2

1

0

Small-scale

0.518

High

752596

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.514

High

735398

MCM10
Minichromosome maintenance protein 10

1

0

Small-scale

0.480

High

740607

IME2
Meiosis induction protein kinase IME2/SME1

1

0

Small-scale

0.480

High

865459

CDT1
Cell division cycle protein CDT1

1

0

Small-scale

0.480

High

381592

H2B2
Histone H2B.2

1

1

High-throughput

0.479

High

824990

FKH1
Fork head protein homolog 1

1

1

Small-scale

0.479

High

836146

FKH2
Fork head protein homolog 2

1

1

Small-scale

0.479

High

808239

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

0

Small-scale

0.460

High

824974

CSM2
Chromosome segregation in meiosis protein 2

1

0

Small-scale

0.460

High

932318

NOC3
Nucleolar complex-associated protein 3

1

0

Small-scale

0.460

High

932319

PSY3
Platinum sensitivity protein 3

1

0

Small-scale

0.460

High

382271

H4
Histone H4

1

0

High-throughput

0.458

High

419833

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

440963

CDC7
Cell division control protein 7

1

0

Small-scale

0.458

High

450740

KAD2
Adenylate kinase

1

0

Small-scale

0.458

High

639869

SIR1
Regulatory protein SIR1

1

0

Small-scale

0.458

High

745836

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

763963

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

858414

SUM1
Suppressor of mar1-1 protein

1

0

Small-scale

0.458

High

924234

IPI3
Pre-rRNA-processing protein IPI3

1

0

Small-scale

0.458

High

924981

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

932316

SPP1
COMPASS component SPP1

1

0

Small-scale

0.458

High

932317

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

932322

H2AZ
Histone H2A.Z

1

1

High-throughput

0.445

High

740540

SUA5
Threonylcarbamoyl-AMP synthase

1

0

High-throughput

0.438

High

736697

ASF1
Histone chaperone ASF1

1

0

High-throughput

0.426

High

742164

HSP7F
Heat shock protein homolog SSE1

1

0

High-throughput

0.426

High

819489

SSB2
Ribosome-associated molecular chaperone SSB2

1

0

High-throughput

0.426

High

932315

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

0

High-throughput

0.426

High

789837

YC16
UPF0743 protein YCR087C-A

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025