Protein: DSC3
DSC E3 ubiquitin ligase complex subunit 3 (Defective for SREBP cleavage protein 3)

Gene: DSC3
Organism: Saccharomyces cerevisiae S288C
Interactions: 23
UniProt ID: Q12015

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000328 - fungal-type vacuole lumen
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1084096

UBX3
UBX domain-containing protein 3

4

1

Small-scale

0.683

High

1062776

DSC2
DSC E3 ubiquitin ligase complex subunit 2

3

0

Small-scale

0.628

High

1053903

ORM2
Protein ORM2

2

0

Small-scale

0.559

High

781031

TUL1
Transmembrane E3 ubiquitin-protein ligase 1

1

1

Small-scale

0.536

High

802500

LAG1
Ceramide synthase LAG1

1

0

High-throughput

0.486

High

815074

SNF7
Vacuolar-sorting protein SNF7

1

0

High-throughput

0.460

High

919530

AP18B
Clathrin coat assembly protein AP180B

1

0

High-throughput

0.460

High

734761

HMX1
Heme-binding protein HMX1

1

0

Small-scale

0.458

High

826991

VLD1
Vacuole localized DSC protein 1

1

0

Small-scale

0.458

High

1053605

GLD1
Golgi/endosome-localized DSC protein 1

1

0

Small-scale

0.458

High

1042112

FCP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.439

High

1038559

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.417

High

477648

MYO1
Myosin-1

1

0

High-throughput

0.251

Low

672473

STE50
Protein STE50

1

0

High-throughput

0.251

Low

753155

NIP80
Protein NIP100

1

0

High-throughput

0.251

Low

796382

FL2D
Protein MUM2

1

0

High-throughput

0.251

Low

858529

STB2
Protein STB2

1

0

High-throughput

0.251

Low

1043929

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

High-throughput

0.251

Low

1084097

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.251

Low

752854

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.249

Low

793000

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.238

Low

924766

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.238

Low

804541

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025