Protein: STE50
Protein STE50

Gene: STE50
Organism: Saccharomyces cerevisiae S288C
Interactions: 134
UniProt ID: P25344

Gene Ontology (top 5):
GO:0000750 - pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO:0001402 - signal transduction involved in filamentous growth
GO:0005737 - cytoplasm
GO:0007232 - osmosensory signaling pathway via Sho1 osmosensor
GO:0019887 - protein kinase regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

672371

STE50
Protein STE50

3

1

Small-scale

0.850

High

660308

STE11
Serine/threonine-protein kinase STE11

27

1

Small-scale

0.769

High

672468

OPY2
Protein OPY2

5

0

Small-scale

0.692

High

448583

RHO2
GTP-binding protein RHO2

1

2

Small-scale

0.647

High

672438

RHO5
GTP-binding protein RHO5

1

1

Small-scale

0.647

High

672406

GIC1
GTPase-interacting component 1

3

1

High-throughput

0.639

High

672467

GIC2
GTPase-interacting component 2

3

1

High-throughput

0.639

High

672416

SHO1
High osmolarity signaling protein SHO1

3

0

Small-scale

0.636

High

672465

ATG17
Autophagy-related protein 17

2

0

High-throughput

0.587

High

618326

CDC42
Cell division control protein 42

1

0

Small-scale

0.586

High

672444

RHO3
GTP-binding protein RHO3

1

1

Small-scale

0.579

High

672389

STE5
Protein STE5

2

0

Small-scale

0.577

High

523157

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.576

High

526004

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.576

High

617373

GBB
Guanine nucleotide-binding protein subunit beta

2

0

Small-scale

0.559

High

672439

CBK1
Serine/threonine-protein kinase CBK1

2

0

Small-scale

0.559

High

672400

AKL1
Serine/threonine-protein kinase AKL1

2

0

High-throughput

0.551

High

672372

RHEB
GTP-binding protein RHB1

1

0

Small-scale

0.541

High

454408

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

672380

XPO1
Exportin-1

1

0

High-throughput

0.513

High

672404

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

1

Small-scale

0.501

High

665165

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.493

High

672405

RIM4
Meiotic activator RIM4

1

0

High-throughput

0.493

High

672433

ARI1
NADPH-dependent aldehyde reductase ARI1

1

0

High-throughput

0.493

High

672477

PST2
Protoplast secreted protein 2

1

0

High-throughput

0.486

High

672418

TBP6
Probable 26S proteasome subunit YTA6

1

1

High-throughput

0.481

High

656375

KC11
Casein kinase I homolog 1

1

0

Small-scale

0.480

High

672383

HOG1
Mitogen-activated protein kinase HOG1

1

0

Small-scale

0.480

High

672476

GIN4
Serine/threonine-protein kinase GIN4

1

0

Small-scale

0.480

High

154350

YO304
Uncharacterized protein YOR304C-A

1

0

High-throughput

0.460

High

460312

SYV
Valine--tRNA ligase, mitochondrial

1

0

High-throughput

0.460

High

477518

MYO1
Myosin-1

1

0

High-throughput

0.460

High

672382

SP110
Spindle pole body component 110

1

0

High-throughput

0.460

High

672391

SPC29
Spindle pole component 29

1

0

High-throughput

0.460

High

672392

NIP80
Protein NIP100

1

0

High-throughput

0.460

High

672396

DYHC
Dynein heavy chain, cytoplasmic

1

0

High-throughput

0.460

High

672399

DAD2
DASH complex subunit DAD2

1

0

High-throughput

0.460

High

672402

FL2D
Protein MUM2

1

0

High-throughput

0.460

High

672409

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.460

High

672414

VAB2
Biogenesis of lysosome-related organelles complex 1 subunit VAB2

1

0

High-throughput

0.460

High

672422

FAR3
Factor arrest protein 3

1

0

High-throughput

0.460

High

672423

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.460

High

672424

VPS53
Vacuolar protein sorting-associated protein 53

1

0

High-throughput

0.460

High

672425

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.460

High

672431

PSP1
Protein PSP1

1

0

High-throughput

0.460

High

672442

HSK3
DASH complex subunit HSK3

1

0

High-throughput

0.460

High

672446

MDM1
Structural protein MDM1

1

0

High-throughput

0.460

High

672458

VPS20
Vacuolar protein sorting-associated protein 20

1

0

High-throughput

0.460

High

672469

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.460

High

672478

GYP5
GTPase-activating protein GYP5

1

0

High-throughput

0.460

High

672479

SKS1
Serine/threonine-protein kinase SKS1

1

0

High-throughput

0.460

High

578911

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

672390

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.458

High

672413

SAP1
Protein SAP1

1

1

High-throughput

0.457

High

672385

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

672432

MGA1
Protein MGA1

1

1

High-throughput

0.439

High

672445

SED5
Integral membrane protein SED5

1

1

High-throughput

0.439

High

672450

TLG1
t-SNARE affecting a late Golgi compartment protein 1

1

1

High-throughput

0.439

High

672375

AHC2
ADA histone acetyltransferase complex component 2

1

0

High-throughput

0.438

High

672435

DAM1
DASH complex subunit DAM1

1

0

Small-scale

0.438

High

672441

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.438

High

672449

BECN1
Vacuolar protein sorting-associated protein 30

1

0

High-throughput

0.438

High

672466

HPA2
Histone acetyltransferase HPA2

1

0

High-throughput

0.438

High

672481

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

0

High-throughput

0.438

High

543924

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

590544

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

672459

SPC24
Kinetochore protein SPC24

2

0

Small-scale

0.310

High

672377

DPB3
DNA polymerase epsilon subunit C

1

0

High-throughput

0.269

Low

672403

MBA1
Inner membrane mitoribosome receptor MBA1, mitochondrial

1

0

High-throughput

0.269

Low

672434

ITC1
Imitation switch two complex protein 1

1

0

High-throughput

0.269

Low

431984

ATPF
ATP synthase subunit 4, mitochondrial

1

0

High-throughput

0.251

Low

454032

GCR1
Glycolytic genes transcriptional activator GCR1

1

0

High-throughput

0.251

Low

639478

RE107
Recombination protein 107

1

0

High-throughput

0.251

Low

643604

SNF2
Transcription regulatory protein SNF2

1

0

High-throughput

0.251

Low

672373

BOS1
Protein transport protein BOS1

1

0

High-throughput

0.251

Low

672374

SGF29
SAGA complex subunit SGF29

1

0

High-throughput

0.251

Low

672376

MSH1
DNA mismatch repair protein MSH1, mitochondrial

1

0

High-throughput

0.251

Low

672381

ATP7
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.251

Low

672388

VAM7
Vacuolar morphogenesis protein 7

1

0

High-throughput

0.251

Low

672393

SCD5
Protein SCD5

1

0

High-throughput

0.251

Low

672395

YKF0
Uncharacterized protein YKL050C

1

0

High-throughput

0.251

Low

672397

EBP2
rRNA-processing protein EBP2

1

0

High-throughput

0.251

Low

672401

QDR3
Quinidine resistance protein 3

1

0

High-throughput

0.251

Low

672407

LAM4
Membrane-anchored lipid-binding protein LAM4

1

0

High-throughput

0.251

Low

672408

SKN7
Transcription factor SKN7

1

0

High-throughput

0.251

Low

672411

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.251

Low

672415

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.251

Low

672417

NACB2
Nascent polypeptide-associated complex subunit beta-2

1

0

High-throughput

0.251

Low

672419

ATAD2
ATPase histone chaperone YTA7

1

0

High-throughput

0.251

Low

672420

CBF3B
Centromere DNA-binding protein complex CBF3 subunit B

1

0

High-throughput

0.251

Low

672426

EAF6
Chromatin modification-related protein EAF6

1

0

High-throughput

0.251

Low

672429

CCM1
Mitochondrial 15S rRNA processing factor CCM1

1

0

High-throughput

0.251

Low

672430

KEL2
Kelch repeat-containing protein 2

1

0

High-throughput

0.251

Low

672437

RM50
Large ribosomal subunit protein bL9m

1

0

High-throughput

0.251

Low

672443

CTR9
RNA polymerase-associated protein CTR9

1

0

High-throughput

0.251

Low

672448

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.251

Low

672452

RCF1
Respiratory supercomplex factor 1, mitochondrial

1

0

High-throughput

0.251

Low

672453

YAP6
AP-1-like transcription factor YAP6

1

0

High-throughput

0.251

Low

672454

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.251

Low

672456

LRS4
Monopolin complex subunit LRS4

1

0

High-throughput

0.251

Low

672460

IVY1
Protein IVY1

1

0

High-throughput

0.251

Low

672461

ENT2
Epsin-2

1

0

High-throughput

0.251

Low

672462

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.251

Low

672464

VTA1
Vacuolar protein sorting-associated protein VTA1

1

0

High-throughput

0.251

Low

672473

DSC3
DSC E3 ubiquitin ligase complex subunit 3

1

0

High-throughput

0.251

Low

672475

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.251

Low

672480

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.251

Low

672378

HIBCH
Small ribosomal subunit protein mS47

1

0

High-throughput

0.249

Low

672379

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

672463

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

150343

YP076
Putative uncharacterized protein YPR076W

1

0

High-throughput

0.238

Low

615003

GLN3
Nitrogen regulatory protein GLN3

1

0

High-throughput

0.238

Low

646714

SEC15
Exocyst complex component SEC15

1

0

High-throughput

0.238

Low

672384

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

0

High-throughput

0.238

Low

672386

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.238

Low

672387

PEP12
Syntaxin PEP12

1

0

High-throughput

0.238

Low

672394

BLI1
Biogenesis of lysosome-related organelles complex 1 subunit BLI1

1

0

High-throughput

0.238

Low

672398

VPS51
Vacuolar protein sorting-associated protein 51

1

0

High-throughput

0.238

Low

672410

IFH1
Protein IFH1

1

0

High-throughput

0.238

Low

672412

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.238

Low

672421

FIP1
Pre-mRNA polyadenylation factor FIP1

1

0

High-throughput

0.238

Low

672427

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.238

Low

672428

SNAPN
Biogenesis of lysosome-related organelles complex 1 subunit SNN1

1

0

High-throughput

0.238

Low

672436

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.238

Low

672440

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.238

Low

672447

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.238

Low

672451

NAA30
N-alpha-acetyltransferase 30

1

0

High-throughput

0.238

Low

672455

SYF1
Pre-mRNA-splicing factor SYF1

1

0

High-throughput

0.238

Low

672457

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.238

Low

672470

ADY3
Accumulates dyads protein 3

1

0

High-throughput

0.238

Low

672471

LDB18
Protein LDB18

1

0

High-throughput

0.238

Low

672472

NTH2
Endonuclease III homolog 2

1

0

High-throughput

0.238

Low

672474

YD016
Putative uncharacterized protein YDL016C

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025