HitPredict

Interactor 1: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Interactor 2: ERCC8 (Q13216)
DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)
Gene: ERCC8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.80	0.757

Property	Details
Experiments	33961781, 29531219, 37689310
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cpn60_TCP1~WD40
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 396
+	Hs
		1098369 TCPH_HUMAN (4-532): 0: 591: 34.08		ERCC8_HUMAN (1-396): 7.4e-86: 268: 100.00
+	Hs
		1334162 TCPH_HUMAN (4-532): 0: 591: 34.08		POC1A_HUMAN (86-395): 2.66e-76: 243: 16.35
+	Hs
		1007146 TCPB_HUMAN (1-535): 0: 586: 100.00		POC1A_HUMAN (86-395): 2.66e-76: 243: 16.35
+	Hs
		1007186 TCPB_HUMAN (1-535): 0: 586: 100.00		FBXW7_HUMAN (128-395): 7.43e-59: 204: 13.76
+	Hs
		1007196 TCPB_HUMAN (1-535): 0: 586: 100.00		SNR40_HUMAN (140-394): 7.84e-54: 183: 13.79
+	Hs
		965190 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR5_HUMAN (218-396): 1.27e-45: 161: 20.44
+	Hs
		964840 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR5_HUMAN (218-396): 1.27e-45: 161: 20.44
+	Hs
		1291941 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR5B_HUMAN (220-396): 5.72e-42: 151: 18.99
+	Hs
		1007118 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR5B_HUMAN (220-396): 5.72e-42: 151: 18.99
+	Hs
		1007162 TCPB_HUMAN (1-535): 0: 586: 100.00		POC1B_HUMAN (228-395): 5.31e-33: 130: 15.29
+	Hs
		1407594 TCPH_HUMAN (4-532): 0: 591: 34.08		NLE1_HUMAN (278-396): 5.12e-23: 102: 15.75
+	Hs
		1007305 TCPB_HUMAN (1-535): 0: 586: 100.00		NLE1_HUMAN (278-396): 5.12e-23: 102: 15.75
+	Hs
		1158975 TCPH_HUMAN (4-532): 0: 591: 34.08		RBBP7_HUMAN (129-368): 4.28e-15: 78.3: 19.22
+	Hs
		1007033 TCPB_HUMAN (1-535): 0: 586: 100.00		RBBP7_HUMAN (129-368): 4.28e-15: 78.3: 19.22
+	Hs
		1086898 TCPH_HUMAN (4-532): 0: 591: 34.08		CDC20_HUMAN (69-352): 8.14e-11: 65.5: 23.81
+	Hs
		209325 TCPH_HUMAN (4-532): 0: 591: 34.08		PRP4_HUMAN (89-272): 1.17e-10: 65.1: 26.27
+	Hs
		1006991 TCPB_HUMAN (1-535): 0: 586: 100.00		CDC20_HUMAN (69-352): 8.14e-11: 65.5: 23.81
+	Hs
		209247 TCPB_HUMAN (1-535): 0: 586: 100.00		PRP4_HUMAN (89-272): 1.17e-10: 65.1: 26.27
+	Zm
		81214 G2XK63_MAIZE (11-530): 0: 565: 68.65		B4FZY9_MAIZE (10-173): 2.01e-14: 76: 17.88
+	Sc
		810783 TCPB_YEAST (9-532): 0: 566: 65.71		RAD28_YEAST (98-272): 1.54e-12: 70.9: 26.80