HitPredict

Interactor 1: CCL7 (P80098)
C-C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP-3) (NC28) (Small-inducible cytokine A7)
Gene: CCL7

Interactor 2: ACKR4 (Q9NPB9)
Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR)
Gene: ACKR4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	10734104
Identification Methods	biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 99 Hs			1 350
+	Hs
		906999 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		CCR5_HUMAN (13-349): 4.57e-92: 280: 30.52
+	Hs
		598257 CL3L1_HUMAN (1-94): 5.48e-36: 119: 36.17		CCR5_HUMAN (13-349): 4.57e-92: 280: 30.52
+	Hs
		906993 CCL7_HUMAN (17-99): 7.86e-35: 116: 100.00		CCR5_HUMAN (13-349): 4.57e-92: 280: 30.52
+	Hs
		906964 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		CCR3_HUMAN (7-349): 1.82e-86: 266: 29.23
+	Hs
		598256 CL3L1_HUMAN (1-94): 5.48e-36: 119: 36.17		CCR3_HUMAN (7-349): 1.82e-86: 266: 29.23
+	Hs
		906959 CCL7_HUMAN (17-99): 7.86e-35: 116: 100.00		CCR3_HUMAN (7-349): 1.82e-86: 266: 29.23
+	Hs
		1405933 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		ACKR4_HUMAN (1-350): 7.08e-83: 257: 100.00
+	Hs
		141857 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		ACKR2_HUMAN (2-332): 8.71e-81: 252: 32.15
+	Hs
		141812 CCL4_HUMAN (1-93): 5.93e-35: 116: 37.63		ACKR2_HUMAN (2-332): 8.71e-81: 252: 32.15
+	Hs
		141831 CCL7_HUMAN (17-99): 7.86e-35: 116: 100.00		ACKR2_HUMAN (2-332): 8.71e-81: 252: 32.15
+	Hs
		835495 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		CCR2_HUMAN (30-328): 1.07e-70: 226: 30.46
+	Hs
		886123 CCL13_HUMAN (1-98): 1.2e-37: 123: 63.27		CXCR3_HUMAN (2-349): 4.6e-69: 222: 29.63
+	Mm
		533456 CCL3_MOUSE (1-94): 3.7e-35: 117: 37.23		CCR1_MOUSE (10-349): 8.48e-71: 226: 30.64
+	Mm
		533457 CCL3_MOUSE (1-94): 3.7e-35: 117: 37.23		CCR3_MOUSE (30-348): 2.99e-70: 225: 31.39
+	Hs
		835478 CCL7_HUMAN (17-99): 7.86e-35: 116: 100.00		CCR2_HUMAN (30-328): 1.07e-70: 226: 30.46
+	Mm
		518941 CCL2_MOUSE (1-94): 2.84e-36: 121: 53.19		CCR2_MOUSE (29-349): 3.03e-68: 220: 28.40
+	Hs
		598252 CL3L1_HUMAN (1-94): 5.48e-36: 119: 36.17		CCR1_HUMAN (30-348): 6.67e-69: 221: 30.46
+	Hs
		886045 CCL7_HUMAN (17-99): 7.86e-35: 116: 100.00		CXCR3_HUMAN (2-349): 4.6e-69: 222: 29.63
+	Hs
		733328 CCL7_HUMAN (17-99): 7.86e-35: 116: 100.00		CCR1_HUMAN (30-348): 6.67e-69: 221: 30.46
+	Mm
		148091 CCL2_MOUSE (1-94): 2.84e-36: 121: 53.19		ACKR2_MOUSE (22-314): 1.66e-39: 145: 31.37