HitPredict

Interactor 1: H4 (P84040)
Histone H4
Gene: His4

Interactor 2: KMT5A (Q9VFK6)
Histone-lysine N-methyltransferase Set8 (EC 2.1.1.361) (Lysine N-methyltransferase 5A) (PR/SET domain-containing protein 07) (dSET8)
Gene: Set8

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	19001096
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CENP-T_C~SET
Common GO terms	-
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 103 Dm			1 691
+	Hs
		980155 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		EHMT2_HUMAN (412-690): 6.24e-72: 255: 20.41
+	Hs
		980344 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		EHMT1_HUMAN (397-690): 1.26e-69: 249: 19.74
+	Hs
		355475 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		NSD2_HUMAN (377-690): 3.17e-68: 245: 20.82
+	Hs
		980157 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		NSD1_HUMAN (358-690): 5.34e-65: 236: 17.77
+	Hs
		979726 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		EZH2_HUMAN (320-684): 6.56e-67: 235: 16.88
+	Hs
		979532 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		KMT2A_HUMAN (324-688): 2.72e-63: 231: 18.43
+	Hs
		980278 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		NSD3_HUMAN (382-690): 4.75e-63: 230: 20.51
+	Hs
		980387 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		KMT5A_HUMAN (383-689): 2.79e-61: 212: 35.58
+	Hs
		980277 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		SETD2_HUMAN (428-675): 1.02e-52: 199: 19.37
+	Hs
		175869 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		SET1A_HUMAN (456-689): 1.26e-48: 186: 25.00
+	Sc
		382090 H4_YEAST (18-103): 5.88e-41: 132: 90.70		SET1_YEAST (392-689): 4.15e-54: 203: 22.59
+	Hs
		980537 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		KMT2B_HUMAN (509-675): 1.27e-40: 162: 30.54
+	Hs
		980015 H4_HUMAN (1-103): 1.72e-48: 151: 99.03		KMT2C_HUMAN (565-675): 2.48e-30: 130: 36.04