Protein: KMT5A
N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.361) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8)

Gene: KMT5A
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q9NQR1

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

980387

H4
Histone H4

9

13

Small-scale

0.974

High

1447189

DTL
Denticleless protein homolog

3

20

Small-scale

0.861

High

998840

H31
Histone H3.1

2

20

High-throughput

0.789

High

1447195

FBW1A
F-box/WD repeat-containing protein 1A

1

17

Small-scale

0.747

High

551281

PCNA
Proliferating cell nuclear antigen

6

7

Small-scale

0.737

High

502552

H2A1
Histone H2A type 1

1

16

High-throughput

0.691

High

462661

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

3

15

High-throughput

0.662

High

1315654

RN168
E3 ubiquitin-protein ligase RNF168

2

1

Small-scale

0.634

High

1322752

DAW1
Dynein assembly factor with WD repeat domains 1

1

18

High-throughput

0.618

High

1017233

H33
Histone H3.3

1

20

High-throughput

0.618

High

1151976

TWST1
Twist-related protein 1

1

13

Small-scale

0.597

High

993764

UBC9
SUMO-conjugating enzyme UBC9

1

5

Small-scale

0.586

High

302643

RNF8
E3 ubiquitin-protein ligase RNF8

1

11

Small-scale

0.578

High

1247084

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

8

Small-scale

0.578

High

285486

EED
Polycomb protein EED

1

20

Small-scale

0.575

High

1066509

RBBP4
Histone-binding protein RBBP4

1

20

Small-scale

0.575

High

1137538

SUZ12
Polycomb protein SUZ12

1

11

Small-scale

0.575

High

1155803

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

Small-scale

0.575

High

1446883

TF7L2
Transcription factor 7-like 2

1

17

Small-scale

0.561

High

1447191

LEF1
Lymphoid enhancer-binding factor 1

1

13

Small-scale

0.561

High

301225

RL1D1
Ribosomal L1 domain-containing protein 1

1

5

High-throughput

0.536

High

424271

S10A8
Protein S100-A8

1

10

High-throughput

0.536

High

426580

HMGN2
Non-histone chromosomal protein HMG-17

1

2

High-throughput

0.536

High

428526

RLA2
Large ribosomal subunit protein P2

1

1

High-throughput

0.536

High

429005

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.536

High

445073

S10A9
Protein S100-A9

1

11

High-throughput

0.536

High

455875

H10
Histone H1.0

1

2

High-throughput

0.536

High

550484

PABP1
Polyadenylate-binding protein 1

1

6

High-throughput

0.536

High

611985

RL35A
Large ribosomal subunit protein eL33

1

2

High-throughput

0.536

High

612794

RL7
Large ribosomal subunit protein uL30

1

2

High-throughput

0.536

High

650976

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

13

High-throughput

0.536

High

724637

S10A7
Protein S100-A7

1

11

High-throughput

0.536

High

842556

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

960905

RL15
Large ribosomal subunit protein eL15

1

3

High-throughput

0.536

High

961413

RL27
Large ribosomal subunit protein eL27

1

1

High-throughput

0.536

High

961854

RL37A
Large ribosomal subunit protein eL43

1

4

High-throughput

0.536

High

975967

RL7A
Large ribosomal subunit protein eL8

1

4

High-throughput

0.536

High

978743

RL23A
Large ribosomal subunit protein uL23

1

6

High-throughput

0.536

High

985010

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.536

High

985351

RL10A
Large ribosomal subunit protein uL1

1

5

High-throughput

0.536

High

986234

RL8
Large ribosomal subunit protein uL2

1

3

High-throughput

0.536

High

1014209

CBX1
Chromobox protein homolog 1

1

20

High-throughput

0.536

High

1039413

RL6
Large ribosomal subunit protein eL6

1

2

High-throughput

0.536

High

1099042

SRSF9
Serine/arginine-rich splicing factor 9

1

17

High-throughput

0.536

High

1363635

H1X
Histone H1.10

1

1

High-throughput

0.536

High

1380972

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

9

High-throughput

0.536

High

1447192

RALY
RNA-binding protein Raly

1

5

High-throughput

0.536

High

1447196

RL36
Large ribosomal subunit protein eL36

1

4

High-throughput

0.536

High

414681

P53
Cellular tumor antigen p53

1

9

Small-scale

0.501

High

1447194

RL26L
Ribosomal protein uL24-like

1

4

High-throughput

0.489

High

1124155

E2F2
Transcription factor E2F2

1

7

Small-scale

0.481

High

589778

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

877010

KC1A
Casein kinase I isoform alpha

1

3

Small-scale

0.479

High

877241

KC1D
Casein kinase I isoform delta

1

3

Small-scale

0.479

High

983984

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

Small-scale

0.479

High

992345

SKP1
S-phase kinase-associated protein 1

1

2

Small-scale

0.479

High

1005129

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1045808

TF65
Transcription factor p65

1

9

High-throughput

0.479

High

1112727

CUL1
Cullin-1

1

16

Small-scale

0.479

High

1115081

CUL4A
Cullin-4A

1

16

Small-scale

0.479

High

1140910

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1157945

DDB1
DNA damage-binding protein 1

1

7

Small-scale

0.479

High

1247006

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1252047

SPOC1
SPOC domain-containing protein 1

1

2

High-throughput

0.479

High

1438324

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

3

Small-scale

0.479

High

1447190

HDAC6
Protein deacetylase HDAC6

1

20

Small-scale

0.479

High

1447193

FZR1
Fizzy-related protein homolog

1

20

Small-scale

0.479

High

1447197

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

9

Small-scale

0.479

High

1447198

TRRAP
Transformation/transcription domain-associated protein

1

7

High-throughput

0.479

High

1317050

FAM9A
Protein FAM9A

1

2

High-throughput

0.464

High

1446959

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1252569

AEBP2
Zinc finger protein AEBP2

1

20

Small-scale

0.445

High

106696

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

791755

SYUA
Alpha-synuclein

1

0

High-throughput

0.426

High

1407710

EBP2
Probable rRNA-processing protein EBP2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025