Interactor 1: KCNH2 (Q12809)
Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)
Gene: KCNH2

Interactor 2: KCNH2 (Q12809)
Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)
Gene: KCNH2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.896

The method score is based on:

Property Details
Experiments 29507111, 19651618, 8995352, 24931372
Identification Methods fluorescent resonance energy transfer, cross-linking study, molecular sieving, nuclear magnetic resonance
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains cNMP_binding~cNMP_binding, Ion_trans~cNMP_binding, PAS_9~cNMP_binding, Ion_trans~Ion_trans, PAS_9~PAS_9
Common GO terms GO:0000976 - transcription cis-regulatory region binding
GO:0003064 - regulation of heart rate by hormone
GO:0005242 - inward rectifier potassium channel activity
GO:0005249 - voltage-gated potassium channel activity
GO:0005251 - delayed rectifier potassium channel activity
and 32 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 1159
Hs

1 1159
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+ Mm
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Last updated: 15 Jul 2024