HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	36598580
Identification Methods	pull down, unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~PHD, Histone~SET
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 136
+	Hs
		161484 KMT2D_HUMAN (1-5537): 0: 1919: 100.00		H32_HUMAN (1-136): 3.8e-61: 186: 99.27
+	Hs
		998821 EHMT1_HUMAN (4886-5533): 5.22e-112: 394: 15.17		H31_HUMAN (1-136): 1.85e-62: 189: 100.00
+	Hs
		1162047 EHMT1_HUMAN (4886-5533): 5.22e-112: 394: 15.17		H31T_HUMAN (1-136): 9.24e-62: 187: 97.06
+	Hs
		998691 EHMT2_HUMAN (4886-5533): 3.82e-112: 392: 17.77		H31_HUMAN (1-136): 1.85e-62: 189: 100.00
+	Hs
		1017218 EHMT1_HUMAN (4886-5533): 5.22e-112: 394: 15.17		H33_HUMAN (1-136): 1.45e-61: 186: 96.32
+	Hs
		1162004 EHMT2_HUMAN (4886-5533): 3.82e-112: 392: 17.77		H31T_HUMAN (1-136): 9.24e-62: 187: 97.06
+	Hs
		1017122 EHMT2_HUMAN (4886-5533): 3.82e-112: 392: 17.77		H33_HUMAN (1-136): 1.45e-61: 186: 96.32
+	Hs
		1258917 EHMT2_HUMAN (4886-5533): 3.82e-112: 392: 17.77		H32_HUMAN (1-136): 3.8e-61: 186: 99.27
+	Mm
		1017384 EHMT2_MOUSE (4917-5533): 2.27e-99: 355: 18.29		H33_MOUSE (1-136): 1.45e-61: 186: 96.32
+	Hs
		883692 EHMT1_HUMAN (4886-5533): 5.22e-112: 394: 15.17		CENPA_HUMAN (9-133): 7.51e-45: 144: 50.00
+	Mm
		1017361 Q6AXH7_MOUSE (5194-5519): 2.24e-93: 324: 19.48		H33_MOUSE (1-136): 1.45e-61: 186: 96.32
+	Mm
		1017354 EZH2_MOUSE (5194-5519): 9.79e-92: 319: 19.48		H33_MOUSE (1-136): 1.45e-61: 186: 96.32
+	Hs
		998359 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		H31_HUMAN (1-136): 1.85e-62: 189: 100.00
+	Hs
		216410 SUV91_HUMAN (5165-5536): 1.72e-93: 313: 18.38		H31_HUMAN (1-136): 1.85e-62: 189: 100.00
+	Hs
		1155419 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		H31T_HUMAN (1-136): 9.24e-62: 187: 97.06
+	Hs
		1016892 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		H33_HUMAN (1-136): 1.45e-61: 186: 96.32
+	Hs
		216415 SUV91_HUMAN (5165-5536): 1.72e-93: 313: 18.38		H33_HUMAN (1-136): 1.45e-61: 186: 96.32
+	Hs
		216457 SUV91_HUMAN (5165-5536): 1.72e-93: 313: 18.38		H37_HUMAN (1-136): 3.39e-59: 181: 97.06
+	Hs
		1155464 EZH2_HUMAN (5194-5519): 6.58e-90: 314: 18.91		H3C_HUMAN (1-136): 8.62e-59: 179: 93.38
+	Hs
		216462 SUV91_HUMAN (5165-5536): 1.72e-93: 313: 18.38		H3C_HUMAN (1-136): 8.62e-59: 179: 93.38