Protein: ARHG5
Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)

Gene: ARHG5, ARHGEF5
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q12774

Gene Ontology (top 5):
GO:0002102 - podosome
GO:0002408 - myeloid dendritic cell chemotaxis
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005525 - GTP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987591

GRB2
Growth factor receptor-bound protein 2

7

20

High-throughput

0.959

High

961991

RHOA
Transforming protein RhoA

4

20

Small-scale

0.873

High

711331

SHC1
SHC-transforming protein 1

3

20

High-throughput

0.848

High

363194

EGFR
Epidermal growth factor receptor

3

20

Small-scale

0.827

High

855858

CRKL
Crk-like protein

3

20

High-throughput

0.821

High

1085501

PKHG4
Puratrophin-1

2

12

High-throughput

0.783

High

1085528

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.783

High

855604

CRK
Adapter molecule crk

2

20

High-throughput

0.737

High

463483

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.691

High

571948

TRI27
Zinc finger protein RFP

3

5

High-throughput

0.675

High

1085518

TRI54
Tripartite motif-containing protein 54

3

20

High-throughput

0.675

High

1085513

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.656

High

1085514

HBAP1
HSPB1-associated protein 1

3

0

High-throughput

0.646

High

410800

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.618

High

710202

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

1055043

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

20

High-throughput

0.618

High

1085504

WDR74
WD repeat-containing protein 74

1

13

High-throughput

0.618

High

1085529

COG6
Conserved oligomeric Golgi complex subunit 6

3

1

High-throughput

0.613

High

269186

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

681802

RBTN2
Rhombotin-2

2

10

High-throughput

0.606

High

1085506

EPMIP
EPM2A-interacting protein 1

2

1

High-throughput

0.606

High

1085509

SLAI1
SLAIN motif-containing protein 1

2

1

High-throughput

0.606

High

1085524

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

1085525

TBC13
TBC1 domain family member 13

2

3

High-throughput

0.606

High

1085527

ZRAN1
Ubiquitin thioesterase ZRANB1

2

8

High-throughput

0.606

High

730546

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

180278

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

0

High-throughput

0.580

High

587069

ITF2
Transcription factor 4

2

0

High-throughput

0.580

High

1085516

LRAT1
Protein LRATD1

2

0

High-throughput

0.580

High

1085505

PKHG7
Pleckstrin homology domain-containing family G member 7

1

15

High-throughput

0.575

High

1085497

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

19

High-throughput

0.573

High

332980

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

4

High-throughput

0.571

High

478016

SNRPA
U1 small nuclear ribonucleoprotein A

2

11

High-throughput

0.571

High

72411

MI4GD
MIF4G domain-containing protein

1

2

High-throughput

0.536

High

355078

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

17

High-throughput

0.536

High

384406

CRYAA
Alpha-crystallin A chain

1

3

High-throughput

0.536

High

391235

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

549578

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

4

High-throughput

0.536

High

1085500

SF3B3
Splicing factor 3B subunit 3

1

4

High-throughput

0.536

High

1085519

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

666981

CCNE1
G1/S-specific cyclin-E1

1

0

High-throughput

0.518

High

239047

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.513

High

359807

DYR
Dihydrofolate reductase

1

0

High-throughput

0.513

High

1006241

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.513

High

1085503

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.513

High

422003

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

1085520

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

Small-scale

0.493

High

1085515

LOXL4
Lysyl oxidase homolog 4

1

3

High-throughput

0.489

High

652498

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

20

High-throughput

0.481

High

1085499

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

5

High-throughput

0.481

High

342845

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.479

High

385686

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

15

High-throughput

0.479

High

424397

HMGN1
Non-histone chromosomal protein HMG-14

1

4

High-throughput

0.479

High

690947

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

729782

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

904648

MECP2
Methyl-CpG-binding protein 2

1

9

High-throughput

0.479

High

966247

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

971451

1433E
14-3-3 protein epsilon

1

5

High-throughput

0.479

High

990151

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1016807

H33
Histone H3.3

1

6

High-throughput

0.479

High

1049237

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1085498

CUL3
Cullin-3

1

8

High-throughput

0.479

High

1085512

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1085521

CCD86
Coiled-coil domain-containing protein 86

1

5

High-throughput

0.479

High

1085508

CHSS2
Chondroitin sulfate synthase 2

1

0

High-throughput

0.460

High

1085517

SPS2
Selenide, water dikinase 2

1

0

High-throughput

0.460

High

290545

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.458

High

1085526

CTNL1
Alpha-catulin

1

4

Small-scale

0.445

High

1085523

AT131
Endoplasmic reticulum transmembrane helix translocase

1

4

High-throughput

0.439

High

1041983

LMNB2
Lamin-B2

1

13

High-throughput

0.437

High

1085511

BRX1
Ribosome biogenesis protein BRX1 homolog

1

2

High-throughput

0.437

High

1085502

EFHC2
EF-hand domain-containing family member C2

4

0

High-throughput

0.365

High

64177

ARG35
Rho guanine nucleotide exchange factor 35

3

0

High-throughput

0.345

High

1085507

M21D2
Nucleotidyltransferase MB21D2

2

0

High-throughput

0.316

High

690014

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.279

Low

1085522

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.249

Low

1085510

HUS1B
Checkpoint protein HUS1B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025