HitPredict

Interactor 1: CDC16 (Q13042)
Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6)
Gene: CDC16

Interactor 2: FBX5 (Q9UKT4)
F-box only protein 5 (Early mitotic inhibitor 1)
Gene: FBXO5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	26496610, 35271311, 33961781, 16921029, 20360068
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007346 - regulation of mitotic cell cycle GO:0016567 - protein ubiquitination and 1 others more... GO:0051301 - cell division
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 620 Hs			1 447
+	Hs
		1117530 Q4KMX6_HUMAN (75-607): 2.94e-19: 93.7: 12.73		FBX5_HUMAN (1-447): 0: 685: 100.00
+	Hs
		1356136 APC7_HUMAN (75-607): 2.88e-19: 93.7: 12.73		FBX5_HUMAN (1-447): 0: 685: 100.00
+	Hs
		1356114 CDC23_HUMAN (9-383): 2.3e-15: 81.4: 9.71		FBX5_HUMAN (1-447): 0: 685: 100.00
+	Hs
		672923 CDC27_HUMAN (4-194): 3.68e-15: 81: 17.80		FBX5_HUMAN (1-447): 0: 685: 100.00
+	Xl
		1151589 Q6GQ04_XENLA (4-194): 3.2e-15: 81.4: 18.85		FBX43_XENLA (25-447): 6.35e-114: 350: 29.35
+	Hs
		1116878 CDC23_HUMAN (9-383): 2.3e-15: 81.4: 9.71		FBX43_HUMAN (40-447): 2.63e-103: 324: 27.59
+	Hs
		672844 CDC27_HUMAN (4-194): 3.68e-15: 81: 17.80		FBX43_HUMAN (40-447): 2.63e-103: 324: 27.59