HitPredict

Interactor 1: STX3 (Q13277)
Syntaxin-3
Gene: STX3

Interactor 2: SNAB (Q9H115)
Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta)
Gene: NAPB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	25416956, 32296183, 31515488, 29892012, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNAP~SNARE, SNAP~Syntaxin
Common GO terms	GO:0006886 - intracellular protein transport GO:0070062 - extracellular exosome GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 289 Hs			1 298
+	Hs
		898845 STX1B_HUMAN (1-288): 3.94e-79: 243: 59.79		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Hs
		699286 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Hs
		1083986 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Mm
		192858 STX1A_MOUSE (1-287): 5.47e-77: 237: 63.45		SNAA_MOUSE (1-293): 4.83e-109: 319: 83.62
+	Rn
		699171 STX1A_RAT (1-287): 4.85e-77: 238: 63.45		SNAA_RAT (1-293): 2.2e-108: 318: 82.94
+	Hs
		873547 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		SNAA_HUMAN (1-293): 7.24e-109: 319: 83.96
+	Hs
		873540 STX3_HUMAN (1-289): 6.42e-71: 222: 100.00		SNAA_HUMAN (1-293): 7.24e-109: 319: 83.96
+	Hs
		1017786 STX4_HUMAN (1-286): 8.41e-62: 199: 39.32		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Dm
		1095554 STX1A_DROME (2-284): 1.93e-73: 228: 55.59		SNAP_DROME (5-292): 1.02e-103: 306: 62.15
+	Hs
		1328433 X5D7S1_HUMAN (1-285): 6.1e-61: 195: 54.55		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Hs
		873535 STX4_HUMAN (1-286): 8.41e-62: 199: 39.32		SNAA_HUMAN (1-293): 7.24e-109: 319: 83.96
+	Hs
		1233513 STX19_HUMAN (1-260): 5.88e-51: 171: 30.82		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Hs
		1205369 STX12_HUMAN (28-270): 8.2e-51: 170: 25.91		SNAB_HUMAN (1-298): 3.42e-116: 338: 100.00
+	Hs
		269400 STX11_HUMAN (1-273): 2.64e-52: 174: 29.37		SNAA_HUMAN (1-293): 7.24e-109: 319: 83.96
+	Hs
		152142 STX16_HUMAN (39-263): 2.72e-50: 170: 20.96		SNAA_HUMAN (1-293): 7.24e-109: 319: 83.96
+	Hs
		873559 STX12_HUMAN (28-270): 8.2e-51: 170: 25.91		SNAA_HUMAN (1-293): 7.24e-109: 319: 83.96
+	Dm
		1098094 STX1A_DROME (2-284): 1.93e-73: 228: 55.59		Q9U6R9_DROME (4-265): 3.27e-59: 193: 19.70
+	Dm
		1098102 STX1A_DROME (2-284): 1.93e-73: 228: 55.59		Q9VH25_DROME (42-265): 8.61e-52: 173: 19.03
+	Hs
		1205360 STX12_HUMAN (28-270): 8.2e-51: 170: 25.91		SNAG_HUMAN (4-251): 6.3e-69: 218: 24.30
+	Hs
		152173 STX16_HUMAN (39-263): 2.72e-50: 170: 20.96		SNAG_HUMAN (4-251): 6.3e-69: 218: 24.30