HitPredict

Interactor 1: K22O (Q01546)
Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)
Gene: KRT76

Interactor 2: KRT84 (Q9NSB2)
Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24)
Gene: KRT84

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0030280 - structural constituent of skin epidermis GO:0031424 - keratinization GO:0045095 - keratin filament GO:0045109 - intermediate filament organization and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 638 Hs			1 600
+	Hs
		437063 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C7_HUMAN (92-487): 1.26e-146: 433: 62.56
+	Hs
		437365 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		KRT84_HUMAN (1-600): 6.01e-132: 400: 100.00
+	Hs
		437054 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C8_HUMAN (83-508): 1.98e-110: 341: 55.63
+	Hs
		227198 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		KRT86_HUMAN (56-536): 1.51e-89: 287: 59.46
+	Hs
		437255 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C73_HUMAN (1-570): 3.03e-87: 282: 43.71
+	Hs
		341724 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C75_HUMAN (1-479): 7.03e-82: 269: 50.82
+	Hs
		437198 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C71_HUMAN (1-556): 1.53e-77: 256: 42.83
+	Hs
		437077 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C5_HUMAN (1-479): 3.8e-75: 252: 51.32
+	Hs
		437215 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C79_HUMAN (24-552): 4.6e-75: 250: 45.32
+	Hs
		407237 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C6B_HUMAN (1-479): 3.79e-73: 246: 52.98
+	Hs
		437121 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C6C_HUMAN (1-479): 8.82e-73: 245: 53.18
+	Hs
		437176 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C72_HUMAN (78-479): 1.05e-71: 241: 54.21
+	Hs
		385216 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C6A_HUMAN (1-479): 1.04e-70: 239: 52.98
+	Hs
		437236 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C74_HUMAN (3-529): 6.3e-69: 234: 44.80
+	Hs
		437146 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K22O_HUMAN (1-482): 5.4e-65: 226: 48.81
+	Hs
		437069 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K2C3_HUMAN (137-480): 1.79e-61: 216: 61.21
+	Hs
		437172 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		K1H2_HUMAN (54-476): 5.19e-62: 213: 22.64
+	Hs
		300545 K2C8_HUMAN (155-533): 1.42e-168: 491: 63.59		KRT36_HUMAN (65-476): 3.73e-61: 211: 27.12
+	Hs
		341727 K2C7_HUMAN (66-510): 2.57e-144: 429: 58.20		K2C75_HUMAN (1-479): 7.03e-82: 269: 50.82
+	Hs
		385221 K2C7_HUMAN (66-510): 2.57e-144: 429: 58.20		K2C6A_HUMAN (1-479): 1.04e-70: 239: 52.98