HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 126
+	Hs
		918340 HDAC1_HUMAN (1-482): 0: 668: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707620 HDAC1_HUMAN (1-482): 0: 668: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1087306 HDAC2_HUMAN (1-478): 0: 666: 85.92		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1270408 HDAC2_HUMAN (1-478): 0: 666: 85.92		H2B1M_HUMAN (1-126): 5.38e-54: 166: 96.03
+	Hs
		707699 HDAC2_HUMAN (1-478): 0: 666: 85.92		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1038530 HDAC1_HUMAN (1-482): 0: 668: 100.00		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		1270409 HDAC2_HUMAN (1-478): 0: 666: 85.92		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62
+	Hs
		1231218 HDAC2_HUMAN (1-478): 0: 666: 85.92		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		1038606 HDAC1_HUMAN (1-482): 0: 668: 100.00		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		1270361 HDAC2_HUMAN (1-478): 0: 666: 85.92		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		177352 HDAC3_HUMAN (9-434): 0: 574: 57.94		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	At
		1322590 HDA6_ARATH (5-461): 0: 578: 58.04		H2B10_ARATH (3-125): 1.12e-43: 141: 59.71
+	Sc
		355401 RPD3_YEAST (8-421): 0: 580: 61.48		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Sp
		140569 PHD1_SCHPO (7-415): 0: 524: 52.91		H2B1_SCHPO (4-125): 1.24e-45: 145: 70.49
+	Sc
		355947 HOS2_YEAST (10-411): 2.72e-171: 491: 50.00		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355966 HDA1_YEAST (10-329): 4.19e-119: 366: 26.74		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355583 HDA1_YEAST (10-329): 4.19e-119: 366: 26.74		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Hs
		241656 HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		707778 HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		886211 HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41