HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: BTBD8 (Q5XKL5)
BTB/POZ domain-containing protein 8 (AP2-interacting clathrin-endocytosis) (APache)
Gene: BTBD8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	34878901, 35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BTB~Cullin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 1792
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (162-723): 8.62e-117: 386: 12.67
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (162-723): 2.24e-116: 385: 12.84
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (183-723): 4.18e-106: 353: 14.31
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (151-723): 8.06e-97: 327: 12.91
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (179-702): 5.08e-90: 307: 13.14
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (170-623): 9.32e-86: 296: 13.69
+	Hs
		1042167 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL6_HUMAN (192-618): 6.79e-85: 294: 14.56
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (162-756): 1.11e-82: 287: 11.15
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (189-704): 4.47e-77: 270: 11.23
+	Hs
		1042026 CUL3_HUMAN (1-768): 0: 951: 100.00		Q8N4I8_HUMAN (157-467): 9.38e-79: 264: 14.42
+	Hs
		301202 CUL3_HUMAN (1-768): 0: 951: 100.00		RHBT3_HUMAN (15-366): 2.13e-71: 254: 18.28
+	Hs
		1041991 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB2_HUMAN (186-469): 1.86e-63: 231: 20.33
+	Hs
		1042047 CUL3_HUMAN (1-768): 0: 951: 100.00		ABTB2_HUMAN (17-383): 3.69e-56: 215: 13.78
+	Hs
		1041986 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL7_HUMAN (196-430): 6.19e-54: 202: 18.67
+	Hs
		1042070 CUL3_HUMAN (1-768): 0: 951: 100.00		RCBT1_HUMAN (192-366): 5.5e-52: 194: 22.29
+	Hs
		307251 CUL3_HUMAN (1-768): 0: 951: 100.00		RCBT2_HUMAN (192-372): 2.8e-38: 154: 18.23
+	Hs
		214258 CUL3_HUMAN (1-768): 0: 951: 100.00		SPOP_HUMAN (188-345): 7.26e-25: 110: 29.75
+	Hs
		1041805 CUL3_HUMAN (1-768): 0: 951: 100.00		SPOPL_HUMAN (188-342): 9.38e-24: 107: 30.97
+	Hs
		1041715 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH22_HUMAN (207-361): 9.38e-21: 101: 25.81
+	Hs
		1041718 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH26_HUMAN (166-368): 1.47e-19: 97.2: 22.17