HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: BTBD3 (Q9Y2F9)
BTB/POZ domain-containing protein 3
Gene: BTBD3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	32296183, 34878901, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 522
+	Hs
		1042296 CUL3_HUMAN (1-768): 0: 951: 100.00		BTBD6_HUMAN (91-522): 2.99e-134: 401: 79.17
+	Hs
		1042454 CUL3_HUMAN (1-768): 0: 951: 100.00		BTBD2_HUMAN (94-521): 1.95e-128: 386: 45.64
+	Hs
		1042504 CUL3_HUMAN (1-768): 0: 951: 100.00		BTBD1_HUMAN (94-521): 6.89e-119: 360: 43.31
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (60-511): 4.5e-102: 320: 15.65
+	Hs
		1042167 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL6_HUMAN (50-511): 4.47e-93: 297: 16.81
+	Hs
		1041986 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL7_HUMAN (110-409): 1.68e-83: 271: 20.81
+	Hs
		1042329 CUL3_HUMAN (1-768): 0: 951: 100.00		BTBD9_HUMAN (106-374): 5.18e-79: 260: 27.74
+	Hs
		1042026 CUL3_HUMAN (1-768): 0: 951: 100.00		Q8N4I8_HUMAN (100-365): 1.09e-81: 258: 22.39
+	Hs
		238083 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH41_HUMAN (102-343): 1.55e-73: 246: 24.18
+	Hs
		1041991 CUL3_HUMAN (1-768): 0: 951: 100.00		KBTB2_HUMAN (105-398): 4.65e-72: 242: 23.65
+	Hs
		152489 CUL3_HUMAN (1-768): 0: 951: 100.00		ENC1_HUMAN (69-341): 3.49e-72: 242: 21.38
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (369-512): 1.31e-19: 94.1: 12.34
+	Hs
		1042324 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL5_HUMAN (371-511): 7.34e-17: 86: 9.93
+	Hs
		1042489 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL4_HUMAN (371-514): 1.75e-16: 84.5: 12.08
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (371-510): 2.2e-16: 84.1: 8.05
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (356-510): 8.8e-16: 82.2: 9.62
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (375-512): 1.5e-15: 81.4: 8.84
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (377-510): 9.29e-14: 76: 10.35
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (371-519): 4.05e-12: 70.6: 11.05
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (371-515): 5.92e-12: 70.2: 11.03