HitPredict

Interactor 1: F5H5M1 (F5H5M1)
SHC adaptor protein 4
Gene: SHC4

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	28514442
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PID~PID, SH2~SH2
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 344 Hs			1 594
+	Hs
		1247473 SHC4_HUMAN (1-344): 3.13e-104: 320: 100.00		SHC3_HUMAN (1-594): 0: 587: 100.00
+	Mm
		1022208 SHC1_MOUSE (1-334): 1.58e-94: 294: 47.94		SHC1_MOUSE (3-593): 1.01e-176: 514: 47.55
+	Hs
		711240 SHC1_HUMAN (1-334): 6.45e-95: 295: 48.53		SHC1_HUMAN (3-593): 6.56e-176: 512: 47.06
+	Hs
		711308 SHC1_HUMAN (1-334): 6.45e-95: 295: 48.53		SHC2_HUMAN (47-593): 1.12e-146: 437: 44.46
+	Hs
		711374 SHC1_HUMAN (1-334): 6.45e-95: 295: 48.53		ANS1B_HUMAN (11-331): 2.84e-69: 245: 17.68
+	Hs
		711386 SHC1_HUMAN (1-334): 6.45e-95: 295: 48.53		ANS1A_HUMAN (11-377): 8.7e-54: 199: 15.78
+	Hs
		154421 SHC1_HUMAN (1-334): 6.45e-95: 295: 48.53		SH2B2_HUMAN (302-594): 2.65e-49: 183: 20.07
+	Mm
		431339 SHC1_MOUSE (1-334): 1.58e-94: 294: 47.94		SRC_MOUSE (361-594): 3.66e-49: 180: 17.46
+	Hs
		557123 SHC1_HUMAN (1-334): 6.45e-95: 295: 48.53		SRC_HUMAN (361-594): 9.01e-49: 179: 17.79
+	Hs
		463000 SHC1_HUMAN (1-334): 6.45e-95: 295: 48.53		YES_HUMAN (355-594): 4.7e-48: 177: 17.31
+	Hs
		711271 SHC1_HUMAN (1-334): 6.45e-95: 295: 48.53		ABL2_HUMAN (342-592): 2.09e-44: 171: 15.91
+	Mm
		431350 SHC3_MOUSE (1-334): 3.08e-92: 285: 42.58		SRC_MOUSE (361-594): 3.66e-49: 180: 17.46
+	Mm
		431361 SHC2_MOUSE (1-334): 2.5e-91: 285: 40.72		SRC_MOUSE (361-594): 3.66e-49: 180: 17.46
+	Hs
		440393 SHC1_HUMAN (1-334): 6.45e-95: 295: 48.53		FYN_HUMAN (438-585): 1.21e-43: 165: 20.76
+	Hs
		463361 SHC1_HUMAN (1-334): 6.45e-95: 295: 48.53		LYN_HUMAN (404-594): 1.25e-43: 164: 20.69
+	Hs
		987714 SHC4_HUMAN (1-344): 3.13e-104: 320: 100.00		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Rn
		988075 SHC1_RAT (1-334): 1.65e-101: 308: 48.82		GRB2_RAT (445-594): 1.28e-34: 132: 22.08
+	Mm
		1022218 SHC1_MOUSE (1-334): 1.58e-94: 294: 47.94		GRB2_MOUSE (445-594): 3.79e-35: 133: 22.08
+	Hs
		711296 SHC1_HUMAN (1-334): 6.45e-95: 295: 48.53		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08