Protein: SIR1
NAD-dependent protein deacetylase sirtuin-1 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]

Gene: SIR1, Sirt1
Organism: Mus musculus
Interactions: 66
UniProt ID: Q923E4

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000720 - pyrimidine dimer repair by nucleotide-excision repair
GO:0000731 - DNA synthesis involved in DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

250746

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

2

1

Small-scale

0.669

High

139873

CLOCK
Circadian locomoter output cycles protein kaput

2

10

Small-scale

0.649

High

1265845

BMAL1
Basic helix-loop-helix ARNT-like protein 1

2

13

Small-scale

0.628

High

404156

JUN
Transcription factor Jun

2

4

Small-scale

0.612

High

1265756

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

11

Small-scale

0.602

High

740722

PPARG
Peroxisome proliferator-activated receptor gamma

2

20

Small-scale

0.601

High

1142386

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

11

Small-scale

0.597

High

613154

PPARA
Peroxisome proliferator-activated receptor alpha

2

20

Small-scale

0.595

High

607523

HNF1A
Hepatocyte nuclear factor 1-alpha

1

7

Small-scale

0.589

High

222707

PER2
Period circadian protein homolog 2

1

9

Small-scale

0.586

High

978974

TF65
Transcription factor p65

2

7

Small-scale

0.584

High

140308

HDAC1
Histone deacetylase 1

1

9

Small-scale

0.561

High

1206782

Q8BK32
Nuclear receptor corepressor 1

1

3

Small-scale

0.561

High

572270

HXB1
Homeobox protein Hox-B1

1

9

High-throughput

0.541

High

991019

NFE2
Transcription factor NF-E2 45 kDa subunit

1

2

High-throughput

0.541

High

509339

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.536

High

830720

HNF4A
Hepatocyte nuclear factor 4-alpha

1

14

Small-scale

0.536

High

1265848

CITE4
Cbp/p300-interacting transactivator 4

1

0

High-throughput

0.518

High

192491

SMAD7
Mothers against decapentaplegic homolog 7

1

1

Small-scale

0.515

High

345625

FOS
Protein c-Fos

1

5

Small-scale

0.515

High

542942

JUND
Transcription factor JunD

1

4

Small-scale

0.515

High

1131968

ACACA
Acetyl-CoA carboxylase 1

1

16

Small-scale

0.515

High

1141976

NCOR1
Nuclear receptor corepressor 1

1

9

Small-scale

0.515

High

1143684

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

12

Small-scale

0.515

High

1265837

SNW1
SNW domain-containing protein 1

1

2

Small-scale

0.515

High

659689

RXRA
Retinoic acid receptor RXR-alpha

1

18

Small-scale

0.501

High

1265847

NCOR2
Nuclear receptor corepressor 2

1

8

Small-scale

0.501

High

60496

A5D6Q2
Ncoa3 protein

1

12

High-throughput

0.481

High

70587

B2RR24
Zinc finger protein 236

1

2

High-throughput

0.481

High

70937

EP300
Histone acetyltransferase p300

1

11

Small-scale

0.479

High

102604

G3X8V5
ORC ubiquitin ligase 1

1

1

Small-scale

0.479

High

139253

ERR1
Steroid hormone receptor ERR1

1

15

Small-scale

0.479

High

356882

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

623701

PAX3
Paired box protein Pax-3

1

2

Small-scale

0.479

High

627500

NECD
Necdin

1

3

Small-scale

0.479

High

724621

IRS1
Insulin receptor substrate 1

1

13

Small-scale

0.479

High

781505

BCL6
B-cell lymphoma 6 protein homolog

1

5

Small-scale

0.479

High

876682

KMT2A
Histone-lysine N-methyltransferase 2A

1

10

Small-scale

0.479

High

946353

IRS2
Insulin receptor substrate 2

1

12

Small-scale

0.479

High

1141186

NR1H4
Bile acid receptor

1

20

Small-scale

0.479

High

1143041

CBX5
Chromobox protein homolog 5

1

6

Small-scale

0.479

High

1145120

HEN2
Helix-loop-helix protein 2

1

5

Small-scale

0.479

High

1208499

KAT5
Histone acetyltransferase KAT5

1

5

Small-scale

0.479

High

1257525

CCAR2
Cell cycle and apoptosis regulator protein 2

1

5

Small-scale

0.479

High

1265834

ATG5
Autophagy protein 5

1

1

Small-scale

0.479

High

1265836

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

5

Small-scale

0.479

High

1265838

KAT8
Histone acetyltransferase KAT8

1

5

Small-scale

0.479

High

1265839

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

Small-scale

0.479

High

1265840

Q9DCC5
Cbx3 protein

1

6

Small-scale

0.479

High

1265841

CAF1A
Chromatin assembly factor 1 subunit A

1

5

High-throughput

0.479

High

1265842

BC11A
B-cell lymphoma/leukemia 11A

1

8

Small-scale

0.479

High

1265843

FOXO1
Forkhead box protein O1

1

13

Small-scale

0.479

High

1265844

HIC1
Hypermethylated in cancer 1 protein

1

6

Small-scale

0.479

High

1265846

SRBP1
Sterol regulatory element-binding protein 1

1

8

Small-scale

0.479

High

1265850

MECP2
Methyl-CpG-binding protein 2

1

3

Small-scale

0.479

High

984751

PGH2
Prostaglandin G/H synthase 2

1

0

Small-scale

0.458

High

985525

Q05BA5
Nuclear receptor coactivator

1

12

High-throughput

0.457

High

1112436

Q3UAV3
Uncharacterized protein

1

1

High-throughput

0.457

High

509491

CDK1
Cyclin-dependent kinase 1

1

6

Small-scale

0.445

High

624391

CCNB1
G2/mitotic-specific cyclin-B1

1

3

Small-scale

0.445

High

638466

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

9

Small-scale

0.445

High

1141187

NR1H2
Oxysterols receptor LXR-beta

1

20

Small-scale

0.445

High

1208361

FTM
Protein fantom

1

7

High-throughput

0.445

High

1208442

BCOR
BCL-6 corepressor

1

10

Small-scale

0.445

High

1265835

FOXP3
Forkhead box protein P3

1

5

Small-scale

0.445

High

1265849

NR1H3
Oxysterols receptor LXR-alpha

1

20

Small-scale

0.445

High


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Last updated: 15 Jul 2024