HitPredict

Interactor 1: REL (Q04864)
Proto-oncogene c-Rel
Gene: REL

Interactor 2: IKBB (Q15653)
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
Gene: NFKBIB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	27609421, 10706725, 8887627, 26186194, 28514442, 33961781, 14743216, 9135156, 16226509, unassigned3799
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~RHD_dimer
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 619 Hs			1 356
+	Hs
		683444 REL_HUMAN (1-619): 0: 692: 100.00		IKBA_HUMAN (14-335): 5.41e-78: 243: 30.21
+	Hs
		1026702 REL_HUMAN (1-619): 0: 692: 100.00		NFKB2_HUMAN (35-347): 1.92e-71: 240: 31.15
+	Hs
		127781 REL_HUMAN (1-619): 0: 692: 100.00		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Mm
		582538 REL_MOUSE (1-619): 0: 628: 70.19		IKBB_MOUSE (1-355): 4.94e-81: 252: 83.52
+	Mm
		582540 REL_MOUSE (1-619): 0: 628: 70.19		IKBA_MOUSE (7-335): 8.96e-77: 240: 31.07
+	Hs
		626195 REL_HUMAN (1-619): 0: 692: 100.00		NFKB1_HUMAN (28-140): 2.08e-10: 64.4: 29.57
+	Mm
		1045971 TF65_MOUSE (2-576): 2e-167: 490: 38.89		IKBB_MOUSE (1-355): 4.94e-81: 252: 83.52
+	Mm
		1046000 TF65_MOUSE (2-576): 2e-167: 490: 38.89		IKBA_MOUSE (7-335): 8.96e-77: 240: 31.07
+	Rn
		1224618 TF65_RAT (2-576): 2.13e-167: 490: 38.48		IKBA_RAT (7-335): 3.81e-76: 238: 30.77
+	Mm
		1045998 TF65_MOUSE (2-576): 2e-167: 490: 38.89		NFKB2_MOUSE (55-347): 8.41e-68: 230: 33.11
+	Hs
		1045325 TF65_HUMAN (2-576): 4.76e-158: 466: 37.89		IKBB_HUMAN (1-356): 4.61e-80: 250: 100.00
+	Hs
		683443 TF65_HUMAN (2-576): 4.76e-158: 466: 37.89		IKBA_HUMAN (14-335): 5.41e-78: 243: 30.21
+	Hs
		1026701 TF65_HUMAN (2-576): 4.76e-158: 466: 37.89		NFKB2_HUMAN (35-347): 1.92e-71: 240: 31.15
+	Mm
		236656 TF65_MOUSE (2-576): 2e-167: 490: 38.89		IKBE_MOUSE (51-333): 1.19e-64: 211: 32.86
+	Mm
		582535 REL_MOUSE (1-619): 0: 628: 70.19		NFKB1_MOUSE (14-140): 5.96e-11: 65.9: 29.46
+	Hs
		127780 TF65_HUMAN (2-576): 4.76e-158: 466: 37.89		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Mm
		681976 TF65_MOUSE (2-576): 2e-167: 490: 38.89		NFKB1_MOUSE (14-140): 5.96e-11: 65.9: 29.46
+	Mm
		681962 NFKB1_MOUSE (1-414): 1.83e-152: 465: 33.56		NFKB1_MOUSE (14-140): 5.96e-11: 65.9: 29.46
+	Hs
		626194 TF65_HUMAN (2-576): 4.76e-158: 466: 37.89		NFKB1_HUMAN (28-140): 2.08e-10: 64.4: 29.57
+	Hs
		1045484 TF65_HUMAN (2-576): 4.76e-158: 466: 37.89		ANKH1_HUMAN (6-91): 4.59e-10: 63.4: 16.28