HitPredict

Interactor 1: SIM2 (Q14190)
Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15)
Gene: SIM2

Interactor 2: ARNT2 (Q9HBZ2)
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Class E basic helix-loop-helix protein 1) (bHLHe1)
Gene: ARNT2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.909

The method score is based on:

Property Details
Experiments 28514442, 33961781, 27472814, 14701734
Identification Methods affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~HLH, HLH~PAS, PAS~PAS, PAS~PAS_11, PAS~PAS_3, PAS_11~PAS_3
Common GO terms GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024