Protein: NCOA1
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)

Gene: NCOA1
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q15788

Gene Ontology (top 5):
GO:0000435 - positive regulation of transcription from RNA polymerase II promoter by galactose
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0002155 - regulation of thyroid hormone receptor signaling pathway
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

396191

ESR1
Estrogen receptor

34

20

Small-scale

0.993

High

789507

PPARG
Peroxisome proliferator-activated receptor gamma

24

20

Small-scale

0.989

High

625823

RXRA
Retinoic acid receptor RXR-alpha

15

20

Small-scale

0.983

High

520589

RARA
Retinoic acid receptor alpha

14

20

Small-scale

0.981

High

543515

VDR
Vitamin D3 receptor

10

20

Small-scale

0.972

High

282942

NR1I2
Nuclear receptor subfamily 1 group I member 2

10

20

Small-scale

0.971

High

838238

STAT6
Signal transducer and activator of transcription 6

7

10

Small-scale

0.968

High

1153778

CBP
CREB-binding protein

8

20

Small-scale

0.965

High

520084

ANDR
Androgen receptor

8

20

Small-scale

0.965

High

404085

GCR
Glucocorticoid receptor

10

20

Small-scale

0.965

High

1153777

ESR2
Estrogen receptor beta

9

20

Small-scale

0.964

High

533350

THB
Thyroid hormone receptor beta

8

20

Small-scale

0.963

High

1060607

PPARA
Peroxisome proliferator-activated receptor alpha

7

20

Small-scale

0.955

High

533290

THA
Thyroid hormone receptor alpha

6

20

Small-scale

0.939

High

1153785

NR1H4
Bile acid receptor

5

20

Small-scale

0.922

High

1041755

PPARD
Peroxisome proliferator-activated receptor delta

5

20

Small-scale

0.916

High

1067375

EP300
Histone acetyltransferase p300

5

20

Small-scale

0.912

High

442942

PRGR
Progesterone receptor

5

20

Small-scale

0.907

High

1134806

NR1I3
Nuclear receptor subfamily 1 group I member 3

4

20

High-throughput

0.897

High

1150386

NCOA2
Nuclear receptor coactivator 2

4

19

Small-scale

0.867

High

1095500

NR1H3
Oxysterols receptor LXR-alpha

3

20

Small-scale

0.850

High

533222

RARB
Retinoic acid receptor beta

3

20

Small-scale

0.840

High

467790

MCR
Mineralocorticoid receptor

3

20

Small-scale

0.839

High

137540

NR5A2
Nuclear receptor subfamily 5 group A member 2

3

20

Small-scale

0.833

High

543577

ERR1
Steroid hormone receptor ERR1

3

20

Small-scale

0.833

High

770999

RORA
Nuclear receptor ROR-alpha

3

20

Small-scale

0.833

High

777289

AHR
Aryl hydrocarbon receptor

2

20

Small-scale

0.821

High

652521

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

2

20

Small-scale

0.768

High

565523

RARG
Retinoic acid receptor gamma

2

20

Small-scale

0.767

High

976898

ERR3
Estrogen-related receptor gamma

2

20

Small-scale

0.767

High

1127873

HNF4G
Hepatocyte nuclear factor 4-gamma

2

20

Small-scale

0.754

High

1153764

Q58EY0
RAR related orphan receptor B isoform 1

2

20

Small-scale

0.754

High

1153801

NCOA3
Nuclear receptor coactivator 3

2

19

Small-scale

0.743

High

693325

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

20

Small-scale

0.740

High

1153779

KAT2B
Histone acetyltransferase KAT2B

4

13

Small-scale

0.698

High

370681

FOS
Protein c-Fos

3

11

Small-scale

0.674

High

921538

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

1

High-throughput

0.667

High

429955

JUN
Transcription factor Jun

3

13

Small-scale

0.662

High

1130568

NCOA6
Nuclear receptor coactivator 6

3

10

Small-scale

0.658

High

1153782

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

3

8

Small-scale

0.655

High

522782

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

20

Small-scale

0.647

High

902782

RORG
Nuclear receptor ROR-gamma

1

20

Small-scale

0.647

High

1153763

HIF1A
Hypoxia-inducible factor 1-alpha

1

20

Small-scale

0.647

High

1153787

SLX1
Structure-specific endonuclease subunit SLX1

2

1

High-throughput

0.628

High

827797

STAT3
Signal transducer and activator of transcription 3

2

10

Small-scale

0.624

High

704533

RXRB
Retinoic acid receptor RXR-beta

1

20

High-throughput

0.621

High

833953

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

Small-scale

0.621

High

933944

NR1H2
Oxysterols receptor LXR-beta

1

20

High-throughput

0.621

High

1101132

STF1
Steroidogenic factor 1

1

20

Small-scale

0.621

High

1148264

NR6A1
Nuclear receptor subfamily 6 group A member 1

1

20

Small-scale

0.621

High

851771

NKX21
Homeobox protein Nkx-2.1

2

16

Small-scale

0.619

High

848103

NR4A2
Nuclear receptor subfamily 4 group A member 2

1

20

Small-scale

0.618

High

1153761

NCOA1
Nuclear receptor coactivator 1

1

19

Small-scale

0.618

High

571987

TRI27
Zinc finger protein RFP

2

5

High-throughput

0.606

High

626247

NFKB1
Nuclear factor NF-kappa-B p105 subunit

2

13

Small-scale

0.602

High

1153770

CARM1
Histone-arginine methyltransferase CARM1

2

8

Small-scale

0.602

High

1153771

F131B
Protein FAM131B

2

0

High-throughput

0.602

High

1153775

TP4AP
Short transient receptor potential channel 4-associated protein

2

0

High-throughput

0.602

High

1153769

RBBP6
E3 ubiquitin-protein ligase RBBP6

2

1

Small-scale

0.584

High

1153790

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

Small-scale

0.569

High

635190

HNF1A
Hepatocyte nuclear factor 1-alpha

1

3

Small-scale

0.561

High

664754

CCND1
G1/S-specific cyclin-D1

1

6

Small-scale

0.561

High

749478

C2TA
MHC class II transactivator

1

1

Small-scale

0.561

High

799149

BRCA1
Breast cancer type 1 susceptibility protein

1

12

Small-scale

0.561

High

1153765

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

9

Small-scale

0.542

High

1153794

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.537

High

1153781

SMRC1
SWI/SNF complex subunit SMARCC1

1

9

Small-scale

0.536

High

74120

VWC2L
von Willebrand factor C domain-containing protein 2-like

1

1

High-throughput

0.536

High

518603

RAP2A
Ras-related protein Rap-2a

1

1

High-throughput

0.536

High

1153784

ANR27
Ankyrin repeat domain-containing protein 27

1

3

High-throughput

0.536

High

700522

PSB9
Proteasome subunit beta type-9

1

4

Small-scale

0.529

High

413909

P53
Cellular tumor antigen p53

1

8

Small-scale

0.527

High

549326

SRF
Serum response factor

1

5

Small-scale

0.527

High

634924

BCL3
B-cell lymphoma 3 protein

1

9

Small-scale

0.527

High

1150229

TEAD2
Transcriptional enhancer factor TEF-4

1

3

Small-scale

0.527

High

1153780

CSN5
COP9 signalosome complex subunit 5

1

3

Small-scale

0.527

High

480154

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

1153799

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.513

High

1111009

SNW1
SNW domain-containing protein 1

1

0

Small-scale

0.505

High

1151338

TRIP4
Activating signal cointegrator 1

1

0

Small-scale

0.504

High

154700

ARI1A
AT-rich interactive domain-containing protein 1A

1

4

Small-scale

0.501

High

278357

NCOR1
Nuclear receptor corepressor 1

1

17

Small-scale

0.501

High

627439

CR2
Complement receptor type 2

1

1

Small-scale

0.501

High

628792

TBP
TATA-box-binding protein

1

1

Small-scale

0.501

High

691039

1433T
14-3-3 protein theta

1

4

Small-scale

0.501

High

703148

TEAD1
Transcriptional enhancer factor TEF-1

1

3

Small-scale

0.501

High

1085561

FOXO1
Forkhead box protein O1

1

15

Small-scale

0.501

High

1153766

ANR11
Ankyrin repeat domain-containing protein 11

1

7

Small-scale

0.501

High

1153786

ANM1
Protein arginine N-methyltransferase 1

1

8

Small-scale

0.501

High

1110899

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.493

High

1153797

FOXA2
Hepatocyte nuclear factor 3-beta

1

6

Small-scale

0.481

High

1025107

TF2B
Transcription initiation factor IIB

1

0

Small-scale

0.480

High

143014

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

180829

TIF1A
Transcription intermediary factor 1-alpha

1

20

Small-scale

0.479

High

210003

CRX
Cone-rod homeobox protein

1

11

High-throughput

0.479

High

291931

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

8

Small-scale

0.479

High

325853

UBR5
E3 ubiquitin-protein ligase UBR5

1

9

Small-scale

0.479

High

341578

EYA4
Protein phosphatase EYA4

1

6

High-throughput

0.479

High

449649

CALCA
Calcitonin gene-related peptide 1

1

1

High-throughput

0.479

High

474014

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

535105

BIP
Endoplasmic reticulum chaperone BiP

1

11

Small-scale

0.479

High

538400

EGR2
E3 SUMO-protein ligase EGR2

1

3

High-throughput

0.479

High

574017

HXB2
Homeobox protein Hox-B2

1

10

High-throughput

0.479

High

577441

ETS1
Protein C-ets-1

1

19

Small-scale

0.479

High

578300

ETS2
Protein C-ets-2

1

19

Small-scale

0.479

High

623359

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

Small-scale

0.479

High

838367

STA5A
Signal transducer and activator of transcription 5A

1

10

Small-scale

0.479

High

853271

CBX5
Chromobox protein homolog 5

1

2

High-throughput

0.479

High

886898

CEBPA
CCAAT/enhancer-binding protein alpha

1

13

High-throughput

0.479

High

930900

HSP72
Heat shock-related 70 kDa protein 2

1

9

Small-scale

0.479

High

934664

TERA
Transitional endoplasmic reticulum ATPase

1

3

Small-scale

0.479

High

995964

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

1

Small-scale

0.479

High

1014523

SMAD3
Mothers against decapentaplegic homolog 3

1

9

Small-scale

0.479

High

1047980

TLE3
Transducin-like enhancer protein 3

1

13

High-throughput

0.479

High

1087761

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1133428

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1150907

TRIPB
Thyroid receptor-interacting protein 11

1

10

Small-scale

0.479

High

1153762

EZH2
Histone-lysine N-methyltransferase EZH2

1

11

Small-scale

0.479

High

1153768

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1153773

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

3

Small-scale

0.479

High

1153774

SP7
Transcription factor Sp7

1

12

High-throughput

0.479

High

1153776

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

4

High-throughput

0.479

High

1153783

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

3

Small-scale

0.479

High

1153789

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

1153792

SYTL2
Synaptotagmin-like protein 2

1

1

Small-scale

0.479

High

1153795

KLF15
Krueppel-like factor 15

1

10

High-throughput

0.479

High

1153800

KCTD3
BTB/POZ domain-containing protein KCTD3

1

2

Small-scale

0.479

High

1004069

CXAR
Coxsackievirus and adenovirus receptor

1

0

Small-scale

0.460

High

1150722

SF01
Splicing factor 1

1

0

Small-scale

0.458

High

1153791

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.458

High

1153793

ZDH18
Palmitoyltransferase ZDHHC18

1

0

Small-scale

0.458

High

1153796

TNIK
TRAF2 and NCK-interacting protein kinase

1

3

High-throughput

0.457

High

1153767

NBEL2
Neurobeachin-like protein 2

1

11

High-throughput

0.445

High

1153798

GRIP1
Glutamate receptor-interacting protein 1

1

0

Small-scale

0.438

High

1153772

ZDH23
Palmitoyltransferase ZDHHC23

1

1

Small-scale

0.437

High

377252

CALC
Calcitonin [Cleaved into: Calcitonin

1

1

High-throughput

0.407

High

192084

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.328

High

1081579

BRME1
Break repair meiotic recombinase recruitment factor 1

2

0

High-throughput

0.328

High

1153788

SPXN
Spexin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025