HitPredict

Interactor 1: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Interactor 2: LMTK2 (Q8IWU2)
Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2)
Gene: LMTK2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 1503
+	Hs
		1050803 PTN12_HUMAN (1-780): 0: 573: 100.00		LMTK1_HUMAN (14-1500): 0: 707: 29.02
+	Hs
		1050795 PTN12_HUMAN (1-780): 0: 573: 100.00		ERBB4_HUMAN (17-748): 2.34e-131: 442: 18.30
+	Hs
		641161 PTN12_HUMAN (1-780): 0: 573: 100.00		FGFR2_HUMAN (33-454): 3.18e-122: 404: 20.52
+	Hs
		1050790 PTN12_HUMAN (1-780): 0: 573: 100.00		FAK2_HUMAN (66-696): 1.74e-117: 396: 17.39
+	Hs
		463284 PTPRC_HUMAN (13-677): 6.94e-141: 449: 19.62		LYN_HUMAN (86-421): 3.37e-109: 358: 22.19
+	Hs
		362175 PTN6_HUMAN (7-364): 6.57e-133: 409: 31.00		ABL1_HUMAN (84-931): 8.08e-117: 397: 18.90
+	Hs
		463360 PTN6_HUMAN (7-364): 6.57e-133: 409: 31.00		LYN_HUMAN (86-421): 3.37e-109: 358: 22.19
+	Hs
		411782 PTN12_HUMAN (1-780): 0: 573: 100.00		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		439707 PTN12_HUMAN (1-780): 0: 573: 100.00		INSR_HUMAN (93-407): 2.86e-34: 145: 32.82
+	Hs
		465494 PTN12_HUMAN (1-780): 0: 573: 100.00		IGF1R_HUMAN (131-399): 1.23e-33: 144: 33.33
+	Hs
		1050786 PTN12_HUMAN (1-780): 0: 573: 100.00		PTK7_HUMAN (28-403): 9.67e-31: 134: 29.05
+	Hs
		840875 PTN12_HUMAN (1-780): 0: 573: 100.00		TEC_HUMAN (123-410): 1.4e-31: 134: 30.61
+	Hs
		411217 PTPRC_HUMAN (13-677): 6.94e-141: 449: 19.62		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		439622 PTPRC_HUMAN (13-677): 6.94e-141: 449: 19.62		INSR_HUMAN (93-407): 2.86e-34: 145: 32.82
+	Hs
		471733 PTPRC_HUMAN (13-677): 6.94e-141: 449: 19.62		TEC_HUMAN (123-410): 1.4e-31: 134: 30.61
+	Hs
		411368 PTPRB_HUMAN (4-314): 9.8e-125: 413: 29.34		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		411420 PTN6_HUMAN (7-364): 6.57e-133: 409: 31.00		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		439641 PTPRB_HUMAN (4-314): 9.8e-125: 413: 29.34		INSR_HUMAN (93-407): 2.86e-34: 145: 32.82
+	Hs
		439655 PTN6_HUMAN (7-364): 6.57e-133: 409: 31.00		INSR_HUMAN (93-407): 2.86e-34: 145: 32.82
+	Hs
		658812 PTPRB_HUMAN (4-314): 9.8e-125: 413: 29.34		TEC_HUMAN (123-410): 1.4e-31: 134: 30.61