HitPredict

Interactor 1: KCNB1 (Q14721)
Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1)
Gene: KCNB1

Interactor 2: KCNG3 (Q8TAE7)
Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv10.1) (Voltage-gated potassium channel subunit Kv6.3)
Gene: KCNG3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.864

Property	Details
Experiments	12060745, 19074135, 11852086
Identification Methods	two hybrid, affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BTB_2~BTB_2, Ion_trans~Ion_trans
Common GO terms	GO:0005251 - delayed rectifier potassium channel activity GO:0005886 - plasma membrane GO:0008076 - voltage-gated potassium channel complex GO:0051260 - protein homooligomerization GO:0071805 - potassium ion transmembrane transport
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 858 Hs			1 436
+	Hs
		1058645 KCNB1_HUMAN (1-858): 0: 725: 100.00		KCNB2_HUMAN (3-434): 1.67e-138: 420: 37.50
+	Hs
		1058633 KCNB1_HUMAN (1-858): 0: 725: 100.00		KCNB1_HUMAN (3-434): 3.45e-138: 418: 37.04
+	Mm
		61654 KCNB1_MOUSE (1-858): 0: 712: 93.71		KCNB2_MOUSE (3-434): 1.31e-138: 421: 37.73
+	Hs
		1058649 KCNB1_HUMAN (1-858): 0: 725: 100.00		KCNG1_HUMAN (9-431): 2.73e-121: 364: 39.95
+	Hs
		1058647 KCNB1_HUMAN (1-858): 0: 725: 100.00		KCNS3_HUMAN (3-421): 4.95e-111: 337: 31.79
+	Hs
		1273152 KCNB2_HUMAN (2-858): 0: 640: 60.68		KCNB2_HUMAN (3-434): 1.67e-138: 420: 37.50
+	Hs
		1058643 KCNB1_HUMAN (1-858): 0: 725: 100.00		KCNG4_HUMAN (11-434): 3.96e-103: 317: 39.58
+	Hs
		1058651 KCNB1_HUMAN (1-858): 0: 725: 100.00		KCNG2_HUMAN (4-425): 2.01e-91: 286: 39.95
+	Hs
		1273162 KCNB2_HUMAN (2-858): 0: 640: 60.68		KCNG1_HUMAN (9-431): 2.73e-121: 364: 39.95
+	Hs
		1251106 KCNB2_HUMAN (2-858): 0: 640: 60.68		KCNG3_HUMAN (1-436): 2.26e-117: 351: 100.00
+	Hs
		1273157 KCNB2_HUMAN (2-858): 0: 640: 60.68		KCNF1_HUMAN (6-436): 3.87e-114: 345: 31.64
+	Hs
		1058636 KCNB1_HUMAN (1-858): 0: 725: 100.00		KCNV1_HUMAN (13-424): 1.06e-78: 254: 35.83
+	Hs
		1273155 KCNB2_HUMAN (2-858): 0: 640: 60.68		KCNS3_HUMAN (3-421): 4.95e-111: 337: 31.79
+	Hs
		1255150 KCNB2_HUMAN (2-858): 0: 640: 60.68		KCNG4_HUMAN (11-434): 3.96e-103: 317: 39.58
+	Hs
		1058644 KCNB1_HUMAN (1-858): 0: 725: 100.00		KCNV2_HUMAN (9-420): 5.75e-68: 227: 34.65
+	Hs
		1161871 KCNB2_HUMAN (2-858): 0: 640: 60.68		KCNV1_HUMAN (13-424): 1.06e-78: 254: 35.83