Interactor 1: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8
Interactor 2: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.94 | 1.00 | 0.972 |
The method score is based on:
Property | Details |
---|---|
Experiments | 16169070, 11832478, 10964557, 8962078, 17290218, 10508785, 10508784, 11717445, 8681376, 17170703 |
Identification Methods | two hybrid, enzymatic study, x-ray crystallography, fluorescent resonance energy transfer, pull down, two hybrid pooling approach |
Interaction Type | direct interaction, association, physical association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | DED~DED, Peptidase_C14~Peptidase_C14 |
Common GO terms | GO:0001525 - angiogenesis GO:0001817 - regulation of cytokine production GO:0004197 - cysteine-type endopeptidase activity GO:0005123 - death receptor binding GO:0005164 - tumor necrosis factor receptor binding and 56 others more... |
Homologous interactions | 17 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024