HitPredict

Interactor 1: TWIST (Q11094)
Twist-related protein (CeTwist) (Helix-loop-helix protein 8)
Gene: hlh-8

Interactor 2: HLH3 (Q22717)
Helix-loop-helix protein 3
Gene: hlh-3

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	23791784
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 178 Ce			1 170
+	Mm
		1221917 NDF1_MOUSE (12-166): 1.46e-32: 121: 25.95		NDF1_MOUSE (18-169): 3.53e-32: 119: 21.05
+	Mm
		518497 MYOD1_MOUSE (10-147): 2.9e-29: 111: 18.12		MYOD1_MOUSE (7-159): 4.8e-25: 99.9: 20.38
+	Dm
		518446 AST4_DROME (15-173): 6.52e-28: 108: 20.10		AST5_DROME (18-157): 2.94e-25: 98: 22.22
+	Hs
		1491472 NGN3_HUMAN (5-146): 2.83e-30: 111: 28.38		NGN3_HUMAN (6-122): 6.4e-24: 94.9: 22.22
+	Mm
		518528 MYOD1_MOUSE (10-147): 2.9e-29: 111: 18.12		ASCL3_MOUSE (16-94): 3.15e-24: 94.5: 36.71
+	Mm
		1000444 NGN2_MOUSE (6-161): 1.76e-28: 107: 22.70		ASCL1_MOUSE (24-125): 5.61e-24: 95.4: 44.12
+	Hs
		1358157 TWST2_HUMAN (4-113): 8.64e-30: 108: 38.18		FER3L_HUMAN (15-92): 1e-23: 93: 33.33
+	Dm
		518477 AST4_DROME (15-173): 6.52e-28: 108: 20.10		AST4_DROME (24-84): 3.99e-22: 92.7: 39.44
+	Mm
		1034668 HAND1_MOUSE (3-116): 1.41e-27: 104: 26.45		ASCL1_MOUSE (24-125): 5.61e-24: 95.4: 44.12
+	Hs
		223953 MYOD1_HUMAN (10-151): 1.09e-26: 104: 18.31		TCF21_HUMAN (6-110): 1.56e-24: 95.3: 25.71
+	Hs
		1273996 OLIG3_HUMAN (10-152): 8.05e-25: 98.7: 26.75		OLIG3_HUMAN (2-155): 1.14e-25: 100: 19.88
+	Mm
		644249 LYL1_MOUSE (3-151): 1.92e-24: 98: 25.00		TAL1_MOUSE (5-165): 5.25e-25: 99.9: 22.16
+	Dm
		653119 Q9VL05_DROME (5-122): 3.06e-26: 99.9: 27.27		MYOD_DROME (2-115): 6.58e-24: 97.2: 28.07
+	Hs
		605203 TAL2_HUMAN (19-119): 8.42e-25: 94.5: 33.33		TAL1_HUMAN (5-165): 8.68e-26: 102: 20.36
+	Hs
		1151966 TWST1_HUMAN (12-113): 2.38e-26: 101: 39.22		TWST2_HUMAN (6-87): 3.67e-24: 94.1: 35.71
+	Dm
		486716 AST4_DROME (15-173): 6.52e-28: 108: 20.10		AST3_DROME (26-124): 9.99e-12: 63: 29.69
+	Mm
		1222210 HAND1_MOUSE (3-116): 1.41e-27: 104: 26.45		HAND2_MOUSE (31-90): 1.8e-11: 61.9: 35.00
+	Mm
		1222208 HAND2_MOUSE (19-90): 4.01e-24: 95.6: 42.47		HAND2_MOUSE (31-90): 1.8e-11: 61.9: 35.00
+	Hs
		960646 HAND2_HUMAN (19-90): 4.01e-24: 95.6: 42.47		HAND2_HUMAN (31-90): 1.8e-11: 61.9: 35.00