HitPredict

Interactor 1: UBP4 (Q13107)
Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)
Gene: USP4

Interactor 2: UBP32 (Q8NFA0)
Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32)
Gene: USP32

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19615732
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DUSP~DUSP, DUSP~Ubiquitin_3, Ubiquitin_3~Ubiquitin_3, UCH~UCH
Common GO terms	GO:0004843 - cysteine-type deubiquitinase activity GO:0005829 - cytosol GO:0006508 - proteolysis GO:0016579 - protein deubiquitination GO:1904263 - positive regulation of TORC1 signaling
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 963 Hs			1 1604
+	Hs
		1338649 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP32_HUMAN (1-1604): 0: 1293: 100.00
+	Hs
		1094564 UBP4_HUMAN (1-963): 0: 900: 100.00		Q4VC15_HUMAN (1217-1604): 1.73e-98: 324: 100.00
+	Hs
		1094654 UBP4_HUMAN (1-963): 0: 900: 100.00		UBP21_HUMAN (718-918): 9.2e-27: 119: 32.74
+	Hs
		1094528 UBP4_HUMAN (1-963): 0: 900: 100.00		UBP4_HUMAN (1430-1596): 1.67e-25: 117: 21.39
+	Hs
		322926 UBP4_HUMAN (1-963): 0: 900: 100.00		UBP19_HUMAN (1339-1585): 3.61e-24: 113: 14.84
+	Hs
		907405 UBP4_HUMAN (1-963): 0: 900: 100.00		UBP11_HUMAN (1445-1581): 2.41e-22: 106: 21.99
+	Hs
		1094663 UBP4_HUMAN (1-963): 0: 900: 100.00		UBP15_HUMAN (897-1072): 5.71e-11: 69.7: 6.77
+	Hs
		1460948 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP21_HUMAN (718-918): 9.2e-27: 119: 32.74
+	Hs
		907638 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP11_HUMAN (1445-1581): 2.41e-22: 106: 21.99
+	Hs
		1490806 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP20_HUMAN (1474-1570): 3.45e-21: 103: 28.00
+	Hs
		1353440 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP33_HUMAN (855-1082): 2.83e-20: 100: 8.73
+	Hs
		907337 UBP11_HUMAN (6-937): 0: 727: 44.49		UBP11_HUMAN (1445-1581): 2.41e-22: 106: 21.99
+	Hs
		288550 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP2_HUMAN (1219-1311): 1.34e-14: 80.9: 33.33
+	Hs
		1491395 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP15_HUMAN (897-1072): 5.71e-11: 69.7: 6.77
+	Mm
		1341662 UBP15_MOUSE (1-927): 0: 739: 57.46		UBP15_MOUSE (897-1072): 6.01e-11: 69.7: 7.29
+	Hs
		828266 UBP15_HUMAN (1-927): 0: 742: 57.88		UBP8_HUMAN (1510-1568): 1.47e-09: 65.1: 38.33
+	Hs
		322886 UBP19_HUMAN (183-937): 3.28e-146: 469: 30.87		UBP19_HUMAN (1339-1585): 3.61e-24: 113: 14.84