HitPredict

Interactor 1: TRAF3 (Q13114)
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)
Gene: TRAF3

Interactor 2: TNR14 (Q92956)
Tumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270)
Gene: TNFRSF14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.608

Property	Details
Experiments	9162022, 10799510
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007166 - cell surface receptor signaling pathway GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 568 Hs			1 283
+	Hs
		622601 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		TNR1A_HUMAN (31-277): 2.08e-53: 181: 20.23
+	Mm
		204649 TRAF3_MOUSE (1-568): 1.24e-157: 464: 96.13		TNR11_MOUSE (22-225): 4.36e-44: 159: 25.47
+	Mm
		693162 TRAF3_MOUSE (1-568): 1.24e-157: 464: 96.13		TNR5_MOUSE (22-225): 1.75e-43: 151: 28.16
+	Hs
		1095019 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		TNR11_HUMAN (38-224): 1.12e-40: 150: 26.80
+	Mm
		894453 TRAF3_MOUSE (1-568): 1.24e-157: 464: 96.13		TNR3_MOUSE (31-203): 6.65e-42: 150: 29.28
+	Hs
		683234 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		TNR5_HUMAN (21-225): 8.88e-43: 149: 28.50
+	Hs
		630265 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		TNR1B_HUMAN (25-214): 1.39e-40: 148: 26.29
+	Hs
		787546 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		TNR3_HUMAN (30-211): 1.78e-39: 144: 28.57
+	Hs
		675015 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		TNR6_HUMAN (44-164): 5.31e-33: 125: 30.89
+	Mm
		866565 TRAF3_MOUSE (1-568): 1.24e-157: 464: 96.13		TNR4_MOUSE (41-213): 3.49e-30: 116: 26.44
+	Hs
		849434 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		TNR4_HUMAN (42-204): 2.41e-24: 100: 25.15
+	Hs
		1095008 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		EDAR_HUMAN (1-161): 1.77e-22: 98: 21.55
+	Mm
		630395 TRAF3_MOUSE (1-568): 1.24e-157: 464: 96.13		TNR9_MOUSE (54-210): 1.04e-22: 96: 27.22
+	Hs
		1057681 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		TNR9_HUMAN (54-207): 1.74e-22: 95.3: 26.45
+	Hs
		689822 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		CD27_HUMAN (37-137): 2.73e-19: 86.8: 30.77
+	Hs
		1094983 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		TNR27_HUMAN (41-151): 7.33e-19: 86: 29.66
+	Mm
		204646 TRAF5_MOUSE (10-567): 9.65e-128: 387: 41.36		TNR11_MOUSE (22-225): 4.36e-44: 159: 25.47
+	Hs
		705911 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		TNR8_HUMAN (59-176): 6.29e-14: 73.3: 22.03
+	Mm
		894452 TRAF5_MOUSE (10-567): 9.65e-128: 387: 41.36		TNR3_MOUSE (31-203): 6.65e-42: 150: 29.28
+	Hs
		466573 TRAF3_HUMAN (1-568): 9.38e-158: 464: 100.00		TNR16_HUMAN (30-125): 3.05e-11: 65.2: 30.39