HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: RHOV (Q96L33)
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)
Gene: RHOV

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2549 Hs			1 236
+	Hs
		787456 MTOR_HUMAN (1-2549): 0: 2102: 100.00		RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44
+	Hs
		787450 MTOR_HUMAN (1-2549): 0: 2102: 100.00		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		787444 MTOR_HUMAN (1-2549): 0: 2102: 100.00		RAB1A_HUMAN (21-234): 6.38e-76: 229: 20.55
+	Hs
		564441 MTOR_HUMAN (1-2549): 0: 2102: 100.00		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		545244 MTOR_HUMAN (1-2549): 0: 2102: 100.00		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		787568 MTOR_HUMAN (1-2549): 0: 2102: 100.00		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Hs
		893980 ATR_HUMAN (186-2548): 0: 816: 14.82		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Hs
		1328163 TRRAP_HUMAN (925-2548): 0: 720: 15.53		RAB1B_HUMAN (25-234): 1.46e-73: 223: 21.03
+	Hs
		545716 TRRAP_HUMAN (925-2548): 0: 720: 15.53		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		901083 TRRAP_HUMAN (925-2548): 0: 720: 15.53		RHOA_HUMAN (33-215): 9.31e-73: 221: 42.62
+	Hs
		894617 TRRAP_HUMAN (925-2548): 0: 720: 15.53		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Hs
		900371 PRKDC_HUMAN (695-2548): 0: 686: 14.83		RHOA_HUMAN (33-215): 9.31e-73: 221: 42.62
+	Mm
		918977 PRKDC_MOUSE (724-2548): 0: 678: 13.46		RAB1A_MOUSE (21-234): 6.38e-76: 229: 20.55
+	Hs
		893894 PRKDC_HUMAN (695-2548): 0: 686: 14.83		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Hs
		925325 Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		892405 Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		564555 Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		545417 Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		900539 Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12		RHOA_HUMAN (33-215): 9.31e-73: 221: 42.62
+	Hs
		894084 Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39