HitPredict

Interactor 1: TRAF3 (Q13114)
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)
Gene: TRAF3

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.768

The method score is based on:

Property Details
Experiments 24763515, 29920243, 31404116, 33372174, 32779804, 34084167, 19380580, 33707416, 37854611, 20174559, 22079989, 23308279, 23717208, 23986588, 26928339, 28049150, 29125880, 27135603, 33411856, 32324863 and 10 others

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Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0019903 - protein phosphatase binding
GO:0032481 - positive regulation of type I interferon production
GO:0034142 - toll-like receptor 4 signaling pathway
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 11Aug2025