HitPredict

Interactor 1: CUL1 (Q24311)
Cullin homolog 1 (Lin-19 homolog protein)
Gene: CUL1

Interactor 2: UBC2M (Q9VSF3)
Nedd8-conjugating enzyme UbcE2M (EC 2.3.2.34) (Nedd8 carrier protein)
Gene: UbcE2M

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21931660
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cullin_Nedd8~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0045879 - negative regulation of smoothened signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 774 Dm			1 181
+	Dm
		639393 CUL1_DROME (1-774): 0: 857: 100.00		UBCD1_DROME (26-170): 1.52e-76: 227: 31.97
+	Hs
		1041136 CUL1_HUMAN (3-774): 0: 825: 61.68		UB2E3_HUMAN (9-170): 2.75e-74: 223: 29.88
+	Hs
		896072 CUL1_HUMAN (3-774): 0: 825: 61.68		UBC12_HUMAN (1-179): 2.11e-69: 210: 73.63
+	Hs
		849326 CUL4A_HUMAN (17-774): 0: 774: 29.84		UB2D1_HUMAN (26-170): 5.02e-77: 228: 28.57
+	Hs
		849325 CUL3_HUMAN (3-774): 0: 771: 27.45		UB2D1_HUMAN (26-170): 5.02e-77: 228: 28.57
+	Hs
		1042304 CUL3_HUMAN (3-774): 0: 771: 27.45		UB2E2_HUMAN (5-170): 4.82e-76: 227: 27.98
+	Hs
		895791 CUL4A_HUMAN (17-774): 0: 774: 29.84		UB2D3_HUMAN (26-170): 1.37e-75: 224: 30.61
+	Hs
		919724 CUL3_HUMAN (3-774): 0: 771: 27.45		UB2D2_HUMAN (26-170): 7.05e-77: 227: 31.29
+	Hs
		1043149 CUL4A_HUMAN (17-774): 0: 774: 29.84		UB2E3_HUMAN (9-170): 2.75e-74: 223: 29.88
+	Hs
		1042223 CUL3_HUMAN (3-774): 0: 771: 27.45		UB2E3_HUMAN (9-170): 2.75e-74: 223: 29.88
+	Hs
		851812 CUL3_HUMAN (3-774): 0: 771: 27.45		UB2E1_HUMAN (6-170): 1.04e-72: 218: 26.35
+	Hs
		896075 CUL4A_HUMAN (17-774): 0: 774: 29.84		UBC12_HUMAN (1-179): 2.11e-69: 210: 73.63
+	Hs
		896074 CUL3_HUMAN (3-774): 0: 771: 27.45		UBC12_HUMAN (1-179): 2.11e-69: 210: 73.63
+	Hs
		895792 CUL4B_HUMAN (3-774): 0: 756: 29.18		UB2D3_HUMAN (26-170): 1.37e-75: 224: 30.61
+	Dm
		1213851 Q8IP45_DROME (3-774): 0: 749: 27.50		UBC2M_DROME (1-181): 3.85e-73: 219: 100.00
+	Hs
		896076 CUL4B_HUMAN (3-774): 0: 756: 29.18		UBC12_HUMAN (1-179): 2.11e-69: 210: 73.63
+	Hs
		828994 CUL4B_HUMAN (3-774): 0: 756: 29.18		UBE2A_HUMAN (24-169): 2.57e-69: 208: 29.73
+	Hs
		849324 CUL2_HUMAN (7-774): 0: 734: 33.04		UB2D1_HUMAN (26-170): 5.02e-77: 228: 28.57
+	Hs
		895790 CUL2_HUMAN (7-774): 0: 734: 33.04		UB2D3_HUMAN (26-170): 1.37e-75: 224: 30.61
+	Hs
		1041134 CUL1_HUMAN (3-774): 0: 825: 61.68		UBE2F_HUMAN (11-166): 6.97e-34: 120: 38.73