HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: PAK3 (O75914)
Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3)
Gene: PAK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0014069 - postsynaptic density GO:0016477 - cell migration GO:0048013 - ephrin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 559
+	Hs
		297090 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		PAK3_HUMAN (1-559): 0: 560: 100.00
+	Hs
		222072 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		PAK1_HUMAN (2-557): 3.68e-171: 497: 76.95
+	Hs
		593982 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		PAK1_HUMAN (2-557): 3.68e-171: 497: 76.95
+	Mm
		312746 NCK1_MOUSE (1-379): 2.32e-88: 273: 68.24		PAK1_MOUSE (2-557): 1.95e-168: 490: 75.53
+	Hs
		222073 NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00		PAK2_HUMAN (1-558): 7.86e-162: 472: 71.40
+	Hs
		593983 NCK1_HUMAN (1-379): 3.58e-88: 272: 68.24		PAK2_HUMAN (1-558): 7.86e-162: 472: 71.40
+	Hs
		297104 ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61		PAK3_HUMAN (1-559): 0: 560: 100.00
+	Ce
		1165105 Q95PW9_CAEEL (1-379): 2.06e-70: 227: 37.63		PK1_CAEEL (6-558): 5.78e-145: 431: 52.14
+	Hs
		463496 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		PAK1_HUMAN (2-557): 3.68e-171: 497: 76.95
+	Hs
		473411 HCK_HUMAN (2-184): 1.58e-23: 103: 21.74		PAK2_HUMAN (1-558): 7.86e-162: 472: 71.40
+	Hs
		463497 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		PAK2_HUMAN (1-558): 7.86e-162: 472: 71.40
+	Hs
		463366 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		AKT2_HUMAN (130-556): 6.85e-146: 430: 22.45
+	Mm
		686931 P85A_MOUSE (166-379): 9.21e-25: 107: 16.36		AKT1_MOUSE (130-553): 2.35e-139: 414: 22.35
+	Hs
		699609 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		AKT1_HUMAN (130-556): 8.19e-139: 412: 21.95
+	Hs
		440402 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		AKT1_HUMAN (130-556): 8.19e-139: 412: 21.95
+	Hs
		605564 P85A_HUMAN (166-379): 7.1e-25: 108: 16.36		KAPCA_HUMAN (242-558): 7.92e-129: 382: 23.57
+	Hs
		136286 P85B_HUMAN (21-380): 2.06e-23: 104: 12.80		KAPCA_HUMAN (242-558): 7.92e-129: 382: 23.57
+	Hs
		440348 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		KAPCA_HUMAN (242-558): 7.92e-129: 382: 23.57
+	Hs
		440524 FYN_HUMAN (7-140): 3.47e-22: 99.9: 19.85		STK4_HUMAN (264-552): 1.45e-125: 378: 42.27
+	Hs
		354504 LYN_HUMAN (2-205): 8.56e-23: 101: 14.56		PAK4_HUMAN (63-283): 1.03e-10: 66.5: 18.30