HitPredict

Interactor 1: ERCC8 (Q13216)
DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)
Gene: ERCC8

Interactor 2: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 0.60 0.751

The method score is based on:

Property Details
Experiments 26496610, 31973889, 33961781, 21145461, 29531219, 34581821, 22902626, unassigned3799
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006974 - DNA damage response
GO:0031464 - Cul4A-RING E3 ubiquitin ligase complex
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 396
Hs

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Service provided by Combinatics, Japan

Last updated: 11Aug2025