HitPredict

Interactor 1: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4

Interactor 2: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 32296183, 24412244, 10531362, 15761153, 9111321, 26555259, 28468752, 12874272, 12167862, 14701756, 9436979, 15231748, 17183365, 11779505, unassigned1304, 35512704, unassigned1913
Identification Methods two hybrid, affinity chromatography technology, molecular sieving, validated two hybrid, anti tag coimmunoprecipitation, pull down, two hybrid array, cosedimentation through density gradient, split luciferase complementation, two hybrid prey pooling approach and 1 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains MH1~MH1, MH2~MH2
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001649 - osteoblast differentiation
and 23 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 552
Hs

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Last updated: 11Aug2025